Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates

Calcium phosphates (CaPs) are very useful biomaterials in bone tissue engineering due to their excellent biological properties. The major difficulties facing in most of the synthesising methods are the size and the shape-controlling of CaP particles. Therefore, the aim of this project is to synthesi...

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Main Author:	Yeo, Chiew Hwee
Format:	Thesis
Language:	English
Published:	2012
Subjects:	TP1-1185 Chemical technology
Online Access:	http://eprints.usm.my/46038/1/YEO%20CHIEW%20HWEE_HJ.pdf
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id	my-usm-ep.46038
record_format	uketd_dc
spelling	my-usm-ep.460382020-01-30T03:03:50Z Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates 2012-01 Yeo, Chiew Hwee TP1-1185 Chemical technology Calcium phosphates (CaPs) are very useful biomaterials in bone tissue engineering due to their excellent biological properties. The major difficulties facing in most of the synthesising methods are the size and the shape-controlling of CaP particles. Therefore, the aim of this project is to synthesise CaP nanoshells by using liposomes as template in order to control the particle size and the shape of the CaP particles. The effectiveness of liposomes (1, 2 dioleoyl-sn-glycero-3-phosphate (sodium salt) (DOPA) and 1, 2-dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (DPPA)) as template were firstly investigated in this project. The results showed that both liposomes formed spherical structures of unilamellar liposomes, in which fulfil the morphology and the size requirement of templates of CaP nanoshells by using suitable preparation method. The effect of concentrations of sodium hydroxide (NaOH) (0.025 M, 0.050 M, 0.075 M, 0.100 M or 0.125 M) and calcium ions (Ca2+) (0.050 M, 0.100 M, 0.150 M or 0.200 M) to the properties of CaP nanoshells prepared using DOPA and DPPA liposome templates were then studied. NaOH plays the role as a base solution to increase the pH, and thus, control the supersaturation of the mixture of CaP nanoshells. In addition, Ca2+ is another main parameter to influence the electrostatic localisation with liposome template and the growth of the CaPs on the liposome template. 2012-01 Thesis http://eprints.usm.my/46038/ http://eprints.usm.my/46038/1/YEO%20CHIEW%20HWEE_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	TP1-1185 Chemical technology
spellingShingle	TP1-1185 Chemical technology Yeo, Chiew Hwee Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
description	Calcium phosphates (CaPs) are very useful biomaterials in bone tissue engineering due to their excellent biological properties. The major difficulties facing in most of the synthesising methods are the size and the shape-controlling of CaP particles. Therefore, the aim of this project is to synthesise CaP nanoshells by using liposomes as template in order to control the particle size and the shape of the CaP particles. The effectiveness of liposomes (1, 2 dioleoyl-sn-glycero-3-phosphate (sodium salt) (DOPA) and 1, 2-dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (DPPA)) as template were firstly investigated in this project. The results showed that both liposomes formed spherical structures of unilamellar liposomes, in which fulfil the morphology and the size requirement of templates of CaP nanoshells by using suitable preparation method. The effect of concentrations of sodium hydroxide (NaOH) (0.025 M, 0.050 M, 0.075 M, 0.100 M or 0.125 M) and calcium ions (Ca2+) (0.050 M, 0.100 M, 0.150 M or 0.200 M) to the properties of CaP nanoshells prepared using DOPA and DPPA liposome templates were then studied. NaOH plays the role as a base solution to increase the pH, and thus, control the supersaturation of the mixture of CaP nanoshells. In addition, Ca2+ is another main parameter to influence the electrostatic localisation with liposome template and the growth of the CaPs on the liposome template.
format	Thesis
qualification_level	Master's degree
author	Yeo, Chiew Hwee
author_facet	Yeo, Chiew Hwee
author_sort	Yeo, Chiew Hwee
title	Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
title_short	Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
title_full	Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
title_fullStr	Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
title_full_unstemmed	Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates
title_sort	synthesis and characterisation of calcium phosphate nanoshells using dopa and dppa liposome templates
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Kimia
publishDate	2012
url	http://eprints.usm.my/46038/1/YEO%20CHIEW%20HWEE_HJ.pdf
_version_	1747821597730799616

Synthesis And Characterisation Of Calcium Phosphate Nanoshells Using DOPA and DPPA Liposome Templates

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