Tocotrienols In Solid Dosage Form

The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20% powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and 1.2 times for alpha, gamma and delta tocotrienols respective...

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Main Author:	Cheah, Mei Mei
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/46068/1/Cheah%20Mei%20Mei24.pdf
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id	my-usm-ep.46068
record_format	uketd_dc
spelling	my-usm-ep.460682020-02-03T04:13:21Z Tocotrienols In Solid Dosage Form 2014-01 Cheah, Mei Mei RS1-441 Pharmacy and materia medica The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20% powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and 1.2 times for alpha, gamma and delta tocotrienols respectively). In addition, it was also found to have better oral bioavailability as compared to Tocomin® 50% oily formulation (1.9, 2.4 and 2.9 times for alpha, gamma and delta tocotrienol respectively). Subsequent usage of Tocomax® 20% powder as the active ingredient for the formulation of tablets containing tocotrienols showed that a satisfactory tablet could be obtained using Neusilin UFL2 and US2 as the diluent, Ac-Di-Sol as the disintegrant and magnesium stearate as the lubricant with the ideal tablet weight of 500 mg per tablet. The tablets were homogeneous in colour and with no physical defects like capping. The tablets also have good disintegration times of approximately 8 minutes and were uniform in weight (less than 2%). The tablets with the optimized formulation were also successfully up-scaled. 2014-01 Thesis http://eprints.usm.my/46068/ http://eprints.usm.my/46068/1/Cheah%20Mei%20Mei24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Cheah, Mei Mei Tocotrienols In Solid Dosage Form
description	The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20% powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and 1.2 times for alpha, gamma and delta tocotrienols respectively). In addition, it was also found to have better oral bioavailability as compared to Tocomin® 50% oily formulation (1.9, 2.4 and 2.9 times for alpha, gamma and delta tocotrienol respectively). Subsequent usage of Tocomax® 20% powder as the active ingredient for the formulation of tablets containing tocotrienols showed that a satisfactory tablet could be obtained using Neusilin UFL2 and US2 as the diluent, Ac-Di-Sol as the disintegrant and magnesium stearate as the lubricant with the ideal tablet weight of 500 mg per tablet. The tablets were homogeneous in colour and with no physical defects like capping. The tablets also have good disintegration times of approximately 8 minutes and were uniform in weight (less than 2%). The tablets with the optimized formulation were also successfully up-scaled.
format	Thesis
qualification_level	Master's degree
author	Cheah, Mei Mei
author_facet	Cheah, Mei Mei
author_sort	Cheah, Mei Mei
title	Tocotrienols In Solid Dosage Form
title_short	Tocotrienols In Solid Dosage Form
title_full	Tocotrienols In Solid Dosage Form
title_fullStr	Tocotrienols In Solid Dosage Form
title_full_unstemmed	Tocotrienols In Solid Dosage Form
title_sort	tocotrienols in solid dosage form
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2014
url	http://eprints.usm.my/46068/1/Cheah%20Mei%20Mei24.pdf
_version_	1747821604087267328

Tocotrienols In Solid Dosage Form

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