Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts

Garcinia atroviridis (GA) is an edible medicinal herb traditionally used for the treatment of earache, throat irritation, cough, dandruff, swollen abdomen and postpartum medication. In the present study, the anti-inflammatory and analgesics activity-guided extraction and fractionation of GA fruit we...

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Main Author:	Mansor, Farah Suhana
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/46088/1/Farah%20Suhana%20Binti%20Mansor24.pdf
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id	my-usm-ep.46088
record_format	uketd_dc
spelling	my-usm-ep.460882020-02-05T02:02:40Z Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts 2014-01 Mansor, Farah Suhana RS1-441 Pharmacy and materia medica Garcinia atroviridis (GA) is an edible medicinal herb traditionally used for the treatment of earache, throat irritation, cough, dandruff, swollen abdomen and postpartum medication. In the present study, the anti-inflammatory and analgesics activity-guided extraction and fractionation of GA fruit were carried out in an attempt to identify anti-inflammatory and analgesic agents which are more potent and with less side effects. The GA fruits were sliced, dried, pulverized and serially extracted with petroleum ether, chloroform, methanol and water using maceration method. The extracts were dried under reduced pressure and freeze-dried. The extraction yield were 1.45%, 0.89%, 21.24% and 7.99% petroleum ether (PE), chloroform (CE), methanol (ME) and water (WE) extracts, respectively. The antiinflammatory activity of the extracts was studied using carrageenan-induced hind paw oedema in rat. Only administered ME at doses of 500 and 1000 mg/kg were found significantly inhibited the hind paw oedema. ME was then fractionated into chloroform (CF), ethyl acetate (EAF), n-butanol (nBF) and water (WF) fractions. Among these four fractions, WF was found to be the most potent in inhibiting the oedema formation. The anti-inflammatory activity of WF was further studied in cotton pellet-induced granuloma in rats, a sub-chronic model of inflammation. WF (125, 250 and 500 mg/kg) significantly inhibited the granuloma formation (p<0.001). Blood cytokine analysis showed that the level of TNF-α and IL-1 in the WF orally treated rats were significantly lower than the control group. 2014-01 Thesis http://eprints.usm.my/46088/ http://eprints.usm.my/46088/1/Farah%20Suhana%20Binti%20Mansor24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Mansor, Farah Suhana Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
description	Garcinia atroviridis (GA) is an edible medicinal herb traditionally used for the treatment of earache, throat irritation, cough, dandruff, swollen abdomen and postpartum medication. In the present study, the anti-inflammatory and analgesics activity-guided extraction and fractionation of GA fruit were carried out in an attempt to identify anti-inflammatory and analgesic agents which are more potent and with less side effects. The GA fruits were sliced, dried, pulverized and serially extracted with petroleum ether, chloroform, methanol and water using maceration method. The extracts were dried under reduced pressure and freeze-dried. The extraction yield were 1.45%, 0.89%, 21.24% and 7.99% petroleum ether (PE), chloroform (CE), methanol (ME) and water (WE) extracts, respectively. The antiinflammatory activity of the extracts was studied using carrageenan-induced hind paw oedema in rat. Only administered ME at doses of 500 and 1000 mg/kg were found significantly inhibited the hind paw oedema. ME was then fractionated into chloroform (CF), ethyl acetate (EAF), n-butanol (nBF) and water (WF) fractions. Among these four fractions, WF was found to be the most potent in inhibiting the oedema formation. The anti-inflammatory activity of WF was further studied in cotton pellet-induced granuloma in rats, a sub-chronic model of inflammation. WF (125, 250 and 500 mg/kg) significantly inhibited the granuloma formation (p<0.001). Blood cytokine analysis showed that the level of TNF-α and IL-1 in the WF orally treated rats were significantly lower than the control group.
format	Thesis
qualification_level	Master's degree
author	Mansor, Farah Suhana
author_facet	Mansor, Farah Suhana
author_sort	Mansor, Farah Suhana
title	Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
title_short	Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
title_full	Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
title_fullStr	Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
title_full_unstemmed	Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts
title_sort	anti-inflammatory and analgesic activities of garcinia atroviridis fruit extracts
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2014
url	http://eprints.usm.my/46088/1/Farah%20Suhana%20Binti%20Mansor24.pdf
_version_	1747821608468217856

Anti-Inflammatory And Analgesic Activities Of Garcinia Atroviridis Fruit Extracts

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