An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts

Garcinia atroviridis (GA) plant has been used as a traditional medicine for treating earache, throat irritation, cough, dandruff and stomach disorders associated with pregnancy and hypertension. In the present study, the anti-hypertensive effectsguided extraction and fractionation of GA fruit were c...

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Main Author:	Kharuddin, Fatim
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/46092/1/Fatim%20Kharuddin24.pdf
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spelling	my-usm-ep.460922020-02-05T07:43:35Z An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts 2014-01 Kharuddin, Fatim RS1-441 Pharmacy and materia medica Garcinia atroviridis (GA) plant has been used as a traditional medicine for treating earache, throat irritation, cough, dandruff and stomach disorders associated with pregnancy and hypertension. In the present study, the anti-hypertensive effectsguided extraction and fractionation of GA fruit were carried out in an attempt to find the most active chemical component. The fruit of this plant was dried, ground and serially extracted with petroleum ether, chloroform, methanol and water. The extracts were dried under reduced pressure and later freeze-dried. The vasodilator effect of the extracts was examined on isolated rat aortic ring preparation. The petroleum ether extract was found to be the most potent in relaxing PE pre-contracted aortic rings. The petroleum ether extract was then fractionated with n-hexane and dichloromethane. The n-hexane fraction (2 mg ml-1) was found to be the most active in relaxing the aortic ring. Removal of the endothelium of the aortic ring did not abolish the relaxing property of petroleum ether extract which suggests that the relaxing effect of the extract is not endothelium dependent. Orally administered all of GA extracts (1 g kg-1) significantly reduced the systolic blood pressure and heart rate of spontaneous hypertensive (SH) rats which support the antihypertensive effect of GA fruit. In anaesthetized rats, the intravenous administration of methanol and water extracts of GA dose-dependently reduced mean arterial pressure (MAP), systolic pressure (SP), diastolic pressure (DP) and heart rate (HR) of SD rats. 2014-01 Thesis http://eprints.usm.my/46092/ http://eprints.usm.my/46092/1/Fatim%20Kharuddin24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Kharuddin, Fatim An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
description	Garcinia atroviridis (GA) plant has been used as a traditional medicine for treating earache, throat irritation, cough, dandruff and stomach disorders associated with pregnancy and hypertension. In the present study, the anti-hypertensive effectsguided extraction and fractionation of GA fruit were carried out in an attempt to find the most active chemical component. The fruit of this plant was dried, ground and serially extracted with petroleum ether, chloroform, methanol and water. The extracts were dried under reduced pressure and later freeze-dried. The vasodilator effect of the extracts was examined on isolated rat aortic ring preparation. The petroleum ether extract was found to be the most potent in relaxing PE pre-contracted aortic rings. The petroleum ether extract was then fractionated with n-hexane and dichloromethane. The n-hexane fraction (2 mg ml-1) was found to be the most active in relaxing the aortic ring. Removal of the endothelium of the aortic ring did not abolish the relaxing property of petroleum ether extract which suggests that the relaxing effect of the extract is not endothelium dependent. Orally administered all of GA extracts (1 g kg-1) significantly reduced the systolic blood pressure and heart rate of spontaneous hypertensive (SH) rats which support the antihypertensive effect of GA fruit. In anaesthetized rats, the intravenous administration of methanol and water extracts of GA dose-dependently reduced mean arterial pressure (MAP), systolic pressure (SP), diastolic pressure (DP) and heart rate (HR) of SD rats.
format	Thesis
qualification_level	Master's degree
author	Kharuddin, Fatim
author_facet	Kharuddin, Fatim
author_sort	Kharuddin, Fatim
title	An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
title_short	An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
title_full	An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
title_fullStr	An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
title_full_unstemmed	An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts
title_sort	experimental study on antihypertensive activity of garcinia atroviridis fruit extracts
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2014
url	http://eprints.usm.my/46092/1/Fatim%20Kharuddin24.pdf
_version_	1747821608953708544

An Experimental Study On Antihypertensive Activity Of Garcinia Atroviridis Fruit Extracts

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