Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts

In this thesis, detailed work was carried out to explore and determine the phytochemical screening, potential anti-infective, antioxidant and analgesic properties of C. ternatea plant parts using various bioassays techniques and appropriate experimental models. The initial qualitative phytochemic...

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Main Author:	Linggam, Kamilla
Format:	Thesis
Language:	English
Published:	2012
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/46098/1/KAMILLA%20LINGGAM_HJ.pdf
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spelling	my-usm-ep.460982020-02-06T01:28:03Z Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts 2012-01 Linggam, Kamilla R735-854 Medical education. Medical schools. Research In this thesis, detailed work was carried out to explore and determine the phytochemical screening, potential anti-infective, antioxidant and analgesic properties of C. ternatea plant parts using various bioassays techniques and appropriate experimental models. The initial qualitative phytochemical screening shows that C. ternatea plant parts contain tannin, phlobatannin, flavonoid, anthraquinone, alkaloid, saponin, cardiac glycosides, volatile oils, steroids and terpenoids. The flavonoids and phenolic content of the various plant parts were also determined in the plant parts. Analysis shows that C. ternatea flower extract has both high phenolic (104.77 ± 2.64 mg GAE/g) and flavonoid (28.10 ± 4.13 mg CE/g) content than other plant parts. This is evident by the fact that C. ternatea flower extract exhibited the highest antioxidant activity (FRAP: 6.80 ± 0.32 μM Fe(II)/g ; DPPH IC50 : 9.17 ± 0.003 μg/mL) when compared to other parts of the plant. One of the bioactives identified in the flower extract was kaempferol-3-glucoside (K3G) which is a flavonoid compound. Kaempferol-3-glucoside was also found in C. ternatea stem and leaf. This could be one of the identified bioactives responsible for the antioxidant activity. As for the in vitro anti-infective screening, both leaf and root crude extracts demonstrated marked antimicrobial activities. Interestingly, the leaf extract demonstrated a remarkable antifungal activity against Aspergillus niger with a MIC and MFC of 0.4 and 0.8 mg/mL, respectively. This was evident by the scanning electron microscope (SEM) analysis which showed a marked morphological alteration of the A. niger hyphal wall and conidiophores after exposure to C. ternatea leaf extract when compared to control. 2012-01 Thesis http://eprints.usm.my/46098/ http://eprints.usm.my/46098/1/KAMILLA%20LINGGAM_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Linggam, Kamilla Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
description	In this thesis, detailed work was carried out to explore and determine the phytochemical screening, potential anti-infective, antioxidant and analgesic properties of C. ternatea plant parts using various bioassays techniques and appropriate experimental models. The initial qualitative phytochemical screening shows that C. ternatea plant parts contain tannin, phlobatannin, flavonoid, anthraquinone, alkaloid, saponin, cardiac glycosides, volatile oils, steroids and terpenoids. The flavonoids and phenolic content of the various plant parts were also determined in the plant parts. Analysis shows that C. ternatea flower extract has both high phenolic (104.77 ± 2.64 mg GAE/g) and flavonoid (28.10 ± 4.13 mg CE/g) content than other plant parts. This is evident by the fact that C. ternatea flower extract exhibited the highest antioxidant activity (FRAP: 6.80 ± 0.32 μM Fe(II)/g ; DPPH IC50 : 9.17 ± 0.003 μg/mL) when compared to other parts of the plant. One of the bioactives identified in the flower extract was kaempferol-3-glucoside (K3G) which is a flavonoid compound. Kaempferol-3-glucoside was also found in C. ternatea stem and leaf. This could be one of the identified bioactives responsible for the antioxidant activity. As for the in vitro anti-infective screening, both leaf and root crude extracts demonstrated marked antimicrobial activities. Interestingly, the leaf extract demonstrated a remarkable antifungal activity against Aspergillus niger with a MIC and MFC of 0.4 and 0.8 mg/mL, respectively. This was evident by the scanning electron microscope (SEM) analysis which showed a marked morphological alteration of the A. niger hyphal wall and conidiophores after exposure to C. ternatea leaf extract when compared to control.
format	Thesis
qualification_level	Master's degree
author	Linggam, Kamilla
author_facet	Linggam, Kamilla
author_sort	Linggam, Kamilla
title	Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
title_short	Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
title_full	Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
title_fullStr	Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
title_full_unstemmed	Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts
title_sort	some pharmacological and phytochemical studies of clitoria ternatea extracts
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah dan Ubat-ubatan
publishDate	2012
url	http://eprints.usm.my/46098/1/KAMILLA%20LINGGAM_HJ.pdf
_version_	1747821609933078528

Some Pharmacological And Phytochemical Studies Of Clitoria Ternatea Extracts

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