Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity

Rheumatoid arthritis (RA) is an inflammatory rheumatic disease characterized by the presence of autoantibodies. This study aims to determine the sensitivity and specificity of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients in relation to rheumatoid factor (...

Full description

Saved in:

Bibliographic Details
Main Author:	Othman, Maizatul Akmal
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/46153/1/Dr.%20Maizatul%20Akmal%20Binti%20Othman-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.46153
record_format	uketd_dc
spelling	my-usm-ep.461532020-02-10T04:14:49Z Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity 2018-01 Othman, Maizatul Akmal RC Internal medicine Rheumatoid arthritis (RA) is an inflammatory rheumatic disease characterized by the presence of autoantibodies. This study aims to determine the sensitivity and specificity of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients in relation to rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP) as well as to determine their association with disease activity score-28 (DAS28) and health assessment questionnaire (HAQ) score. This study included 105 RA patients (48 RFpositive and 57 RF-negative patients) conducted at Hospital Universiti Sains Malaysia (HUSM) from January 2015 until February 2016. Fifty healthy controls (HCs) were included. CRP, RF, anti-CCP and anti-CarP antibodies were measured. HAQ was administered to each of the study participants. DAS28 of the 105 RA patients was measured. The level of anti-CarP antibodies was significantly increased in the RA patients compared to that in the HCs (p=0.042). The sensitivity and specificity of anti-CarP antibodies in RA patients were 42% and 78%, respectively. The presence of anti-CarP antibodies was significantly associated with RF (p=0.019) and the HAQ results (p=0.010). However, there was no significant association ofanti-CarP antibodies with anti-CCP antibodies and CRP (p=0.564 and p=0.075, respectively). Furthermore, a significant association between anti-CarP antibodies with DAS28 was not found (p=0.165). This study provides further evidence that the level of anti-CarP antibodies is significantly elevated in RA patients. In addition, this study showed that anti-CarP-positive RA patients more likely to demonstrate increased disability compared to anti-CarP-negative RA patients. Therefore, anti- CarP antibodies have a potential to be further develop as a biomarker to aid in the diagnosis and prognosis of RA. 2018-01 Thesis http://eprints.usm.my/46153/ http://eprints.usm.my/46153/1/Dr.%20Maizatul%20Akmal%20Binti%20Othman-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Othman, Maizatul Akmal Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
description	Rheumatoid arthritis (RA) is an inflammatory rheumatic disease characterized by the presence of autoantibodies. This study aims to determine the sensitivity and specificity of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients in relation to rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP) as well as to determine their association with disease activity score-28 (DAS28) and health assessment questionnaire (HAQ) score. This study included 105 RA patients (48 RFpositive and 57 RF-negative patients) conducted at Hospital Universiti Sains Malaysia (HUSM) from January 2015 until February 2016. Fifty healthy controls (HCs) were included. CRP, RF, anti-CCP and anti-CarP antibodies were measured. HAQ was administered to each of the study participants. DAS28 of the 105 RA patients was measured. The level of anti-CarP antibodies was significantly increased in the RA patients compared to that in the HCs (p=0.042). The sensitivity and specificity of anti-CarP antibodies in RA patients were 42% and 78%, respectively. The presence of anti-CarP antibodies was significantly associated with RF (p=0.019) and the HAQ results (p=0.010). However, there was no significant association ofanti-CarP antibodies with anti-CCP antibodies and CRP (p=0.564 and p=0.075, respectively). Furthermore, a significant association between anti-CarP antibodies with DAS28 was not found (p=0.165). This study provides further evidence that the level of anti-CarP antibodies is significantly elevated in RA patients. In addition, this study showed that anti-CarP-positive RA patients more likely to demonstrate increased disability compared to anti-CarP-negative RA patients. Therefore, anti- CarP antibodies have a potential to be further develop as a biomarker to aid in the diagnosis and prognosis of RA.
format	Thesis
qualification_level	Master's degree
author	Othman, Maizatul Akmal
author_facet	Othman, Maizatul Akmal
author_sort	Othman, Maizatul Akmal
title	Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
title_short	Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
title_full	Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
title_fullStr	Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
title_full_unstemmed	Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
title_sort	evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46153/1/Dr.%20Maizatul%20Akmal%20Binti%20Othman-24%20pages.pdf
_version_	1747821621690761216

Evaluation of anti-carbamylated protein antibodies as a potential biomarker in assisting the diagnosis of rheumatoid arthritis and its correlation with disease activity

Similar Items