Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts

The current study was aimed to synthesize three series of bisbenzimidazolium salts (12-44) as stable N-heterocyclic carbene (NHC) precursors and their complexation with silver(I) ions in order to obtain dinuclear silver(I)-NHC complexes (45-77). Each series of salts was derived either from para-, me...

Full description

Saved in:

Bibliographic Details
Main Author:	Iqbal, Muhammad Adnan
Format:	Thesis
Language:	English
Published:	2014
Subjects:	TP155-156 Chemical engineering
Online Access:	http://eprints.usm.my/46169/1/Muhammad%20Adnan%20Iqbal24.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.46169
record_format	uketd_dc
spelling	my-usm-ep.461692020-02-11T02:51:25Z Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts 2014-01 Iqbal, Muhammad Adnan TP155-156 Chemical engineering The current study was aimed to synthesize three series of bisbenzimidazolium salts (12-44) as stable N-heterocyclic carbene (NHC) precursors and their complexation with silver(I) ions in order to obtain dinuclear silver(I)-NHC complexes (45-77). Each series of salts was derived either from para-, meta-, or ortho-xylene linked systems having ethyl-decyl, benzyl and i-propyl substituents at number 3-position of benzimidazolium ring. The salts and complexes were characterized by spectroscopy (FT-IR, 1H and 13C NMR), elemental analysis (CHN) and single crystal X-ray diffraction techniques. All the complexes were prepared by in situ reaction of Ag2O with the corresponding bis-benzimidazolium salts and were tested against human colon cancer cells. Selected salts (12-14, 18-20, 21) and respective complexes (45-47, 29-31, 54) were further tested against acute promyelocytic leukaemia and immortalized myelogenous leukaemia cells. The compounds showed potential anticancer activity against all the tested cancer cell lines. Moreover, complexes exhibited higher cytotoxicity compared to respective salts. The anticancer potential of compounds increased with the increase in chain length at position 3-nitrogen. Furthermore, considering the triangular relationship among cancer, inflammation and oxidation, selected compounds were further tested for possible anti-oxidant and anti-inflammatory activities. The tested compounds did not show anti-oxidant behaviour however, proved to have anti-inflammatory activity comparable to the standards used. 2014-01 Thesis http://eprints.usm.my/46169/ http://eprints.usm.my/46169/1/Muhammad%20Adnan%20Iqbal24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	TP155-156 Chemical engineering
spellingShingle	TP155-156 Chemical engineering Iqbal, Muhammad Adnan Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
description	The current study was aimed to synthesize three series of bisbenzimidazolium salts (12-44) as stable N-heterocyclic carbene (NHC) precursors and their complexation with silver(I) ions in order to obtain dinuclear silver(I)-NHC complexes (45-77). Each series of salts was derived either from para-, meta-, or ortho-xylene linked systems having ethyl-decyl, benzyl and i-propyl substituents at number 3-position of benzimidazolium ring. The salts and complexes were characterized by spectroscopy (FT-IR, 1H and 13C NMR), elemental analysis (CHN) and single crystal X-ray diffraction techniques. All the complexes were prepared by in situ reaction of Ag2O with the corresponding bis-benzimidazolium salts and were tested against human colon cancer cells. Selected salts (12-14, 18-20, 21) and respective complexes (45-47, 29-31, 54) were further tested against acute promyelocytic leukaemia and immortalized myelogenous leukaemia cells. The compounds showed potential anticancer activity against all the tested cancer cell lines. Moreover, complexes exhibited higher cytotoxicity compared to respective salts. The anticancer potential of compounds increased with the increase in chain length at position 3-nitrogen. Furthermore, considering the triangular relationship among cancer, inflammation and oxidation, selected compounds were further tested for possible anti-oxidant and anti-inflammatory activities. The tested compounds did not show anti-oxidant behaviour however, proved to have anti-inflammatory activity comparable to the standards used.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Iqbal, Muhammad Adnan
author_facet	Iqbal, Muhammad Adnan
author_sort	Iqbal, Muhammad Adnan
title	Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
title_short	Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
title_full	Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
title_fullStr	Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
title_full_unstemmed	Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts
title_sort	synthesis, structure and in vitro anticancer studies of dinuclear silver(i)-n-heterocyclic carbene complexes derived from xylyl linked bis-benzimidazolium salts
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Kimia
publishDate	2014
url	http://eprints.usm.my/46169/1/Muhammad%20Adnan%20Iqbal24.pdf
_version_	1747821625256968192

Synthesis, Structure And In Vitro Anticancer Studies Of Dinuclear Silver(I)-N-Heterocyclic Carbene Complexes Derived From Xylyl Linked Bis-Benzimidazolium Salts

Similar Items