Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia

The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were scr...

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Main Author:	Mohammed, Omar Saeed Ali
Format:	Thesis
Language:	English
Published:	2013
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf
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id	my-usm-ep.46191
record_format	uketd_dc
spelling	my-usm-ep.461912020-02-12T07:59:31Z Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia 2013-11 Mohammed, Omar Saeed Ali RK1-715 Dentistry The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. 2013-11 Thesis http://eprints.usm.my/46191/ http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RK1-715 Dentistry
spellingShingle	RK1-715 Dentistry Mohammed, Omar Saeed Ali Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
description	The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mohammed, Omar Saeed Ali
author_facet	Mohammed, Omar Saeed Ali
author_sort	Mohammed, Omar Saeed Ali
title	Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
title_short	Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
title_full	Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
title_fullStr	Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
title_full_unstemmed	Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
title_sort	anti-neoplastic studies of standardized root extract of eurycomal longifolia (taf273) towards leukaemia
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2013
url	http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf
_version_	1747821629937811456

Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia

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