Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia
The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were scr...
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2013
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my-usm-ep.461912020-02-12T07:59:31Z Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia 2013-11 Mohammed, Omar Saeed Ali RK1-715 Dentistry The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. 2013-11 Thesis http://eprints.usm.my/46191/ http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
RK1-715 Dentistry |
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RK1-715 Dentistry Mohammed, Omar Saeed Ali Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| description |
The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Mohammed, Omar Saeed Ali |
| author_facet |
Mohammed, Omar Saeed Ali |
| author_sort |
Mohammed, Omar Saeed Ali |
| title |
Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_short |
Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full |
Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_fullStr |
Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_full_unstemmed |
Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia |
| title_sort |
anti-neoplastic studies of standardized root extract of eurycomal longifolia (taf273) towards leukaemia |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Institut Perubatan & Pergigian Termaju |
| publishDate |
2013 |
| url |
http://eprints.usm.my/46191/1/Omar%20Saeed%20Ali%20Mohammed24.pdf |
| _version_ |
1747821629937811456 |