In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger

Infectious disease is one of the commonest health problems in developing countries with the rise of antibiotic resistance. Invasive aspergillosis is causing high mortality and morbidity rate among immunosuppressed patients. Therefore, there is an urgent need for novel antifungal therapy to contro...

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Main Author:	Vello, Sumathy
Format:	Thesis
Language:	English
Published:	2012
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/46274/1/SUMATHY%20VELLO_HJ.pdf
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id	my-usm-ep.46274
record_format	uketd_dc
spelling	my-usm-ep.462742020-02-20T01:26:04Z In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger 2012-01 Vello, Sumathy QH1 Natural history (General - Including nature conservation, geographical distribution) Infectious disease is one of the commonest health problems in developing countries with the rise of antibiotic resistance. Invasive aspergillosis is causing high mortality and morbidity rate among immunosuppressed patients. Therefore, there is an urgent need for novel antifungal therapy to control the fatality rate in the population. Opting on medicinal plants has become the current trend amongst scientific investigators as plants are rich with biological activities. Cassia surattensis flower was studied to identify this organ as a potential antifungal agent. Screening of selected pathogenic microorganisms which were inclusive of Gram positive bacteria, Bacillus subtilis, Bacillus thuringiensis, Micrococcus sp and Staphylococcus aureus, Gram negative bacteria, Escherichia coli, Proteus mirabilis and Salmonella sp and fungi Candida albicans, Aspergillus niger and Rhizopus sp against the flower extract revealed this flower to possess antimicrobial properties. The zone of inhibition for microorganisms from disc diffusion assay ranged from 13 ± 0.04 mm to 18 ± 0.00 mm. Microorganisms that were weak against the flower extract were further evaluated with Minimum Inhibitory Concentration (MIC) assay to determine the flower extract activity against the microorganisms in a dose dependent manner. MIC values for both Gram positive and Gram negative bacteria ranged from 3.125 mg/mL to 25.00 mg/mL. For fungi, the MIC value ranged from 3.125 mg/mL to 6.25 mg/mL. The presence of antifungal agent in the flower extract caused damage to the hyphae and conidiophores of A. niger 2012-01 Thesis http://eprints.usm.my/46274/ http://eprints.usm.my/46274/1/SUMATHY%20VELLO_HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Pendidikan Jarak Jauh
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Vello, Sumathy In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
description	Infectious disease is one of the commonest health problems in developing countries with the rise of antibiotic resistance. Invasive aspergillosis is causing high mortality and morbidity rate among immunosuppressed patients. Therefore, there is an urgent need for novel antifungal therapy to control the fatality rate in the population. Opting on medicinal plants has become the current trend amongst scientific investigators as plants are rich with biological activities. Cassia surattensis flower was studied to identify this organ as a potential antifungal agent. Screening of selected pathogenic microorganisms which were inclusive of Gram positive bacteria, Bacillus subtilis, Bacillus thuringiensis, Micrococcus sp and Staphylococcus aureus, Gram negative bacteria, Escherichia coli, Proteus mirabilis and Salmonella sp and fungi Candida albicans, Aspergillus niger and Rhizopus sp against the flower extract revealed this flower to possess antimicrobial properties. The zone of inhibition for microorganisms from disc diffusion assay ranged from 13 ± 0.04 mm to 18 ± 0.00 mm. Microorganisms that were weak against the flower extract were further evaluated with Minimum Inhibitory Concentration (MIC) assay to determine the flower extract activity against the microorganisms in a dose dependent manner. MIC values for both Gram positive and Gram negative bacteria ranged from 3.125 mg/mL to 25.00 mg/mL. For fungi, the MIC value ranged from 3.125 mg/mL to 6.25 mg/mL. The presence of antifungal agent in the flower extract caused damage to the hyphae and conidiophores of A. niger
format	Thesis
qualification_level	Master's degree
author	Vello, Sumathy
author_facet	Vello, Sumathy
author_sort	Vello, Sumathy
title	In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
title_short	In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
title_full	In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
title_fullStr	In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
title_full_unstemmed	In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger
title_sort	in vitro and in vivo studies of cassia surattensis flower against aspergillus niger
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Pendidikan Jarak Jauh
publishDate	2012
url	http://eprints.usm.my/46274/1/SUMATHY%20VELLO_HJ.pdf
_version_	1747821641937715200

In Vitro And In Vivo Studies Of Cassia Surattensis Flower Against Aspergillus Niger

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