Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery
The aims of the present study were to formulate and evaluate nanomicelles containing poorly water soluble corticosteroids, budesonide (BUD) or beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated polymers (PEG5000-DSPE and PEG2000-DSPE). All the sterically stabilized phosphol...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-usm-ep.46297 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-usm-ep.462972020-02-20T07:25:43Z Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery 2011 Sahib, Mohanad Naji RS1-441 Pharmacy and materia medica The aims of the present study were to formulate and evaluate nanomicelles containing poorly water soluble corticosteroids, budesonide (BUD) or beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated polymers (PEG5000-DSPE and PEG2000-DSPE). All the sterically stabilized phospholipid nanomicelles (SSMs) were successfully prepared using a co-precipitation and reconstitution method. The SSMs were characterised by different physicochemical methods. There were significant differences between the maximum solubilisation tendencies of PEG5000-DSPE and PEG2000-DSPE for BUD, which were approximately 605.71±6.38 and 646.27±4.93 μg/ml, respectively. The maximum solubilisation tendencies of PEG5000-DSPE and PEG2000-DSPE for BDP were approximately 209.65±7.74 and 210.01±5.28, respectively. These results showed that PEGylated polymers had greater tendencies to solubilise BUD than BDP. The mean particle sizes at maximum solubilisation of BUD:PEG2000-DSPE (15.97±1.91 nm) and BDP:PEG2000-DSPE (15.44±1.66 nm) were smaller than BUD:PEG5000-DSPE (20.45±1.65 nm) and BDP:PEG5000-DSPE (19.99±0.98 nm). Blank SSMs of PEG5000-DSPE were successfully lyophilised at a concentration of about 5 mM, while 10 mM of PEG2000-DSPE was needed for lyophilisation. 2011 Thesis http://eprints.usm.my/46297/ http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Sahib, Mohanad Naji Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| description |
The aims of the present study were to formulate and evaluate nanomicelles
containing poorly water soluble corticosteroids, budesonide (BUD) or
beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated
polymers (PEG5000-DSPE and PEG2000-DSPE).
All the sterically stabilized phospholipid nanomicelles (SSMs) were successfully
prepared using a co-precipitation and reconstitution method. The SSMs were
characterised by different physicochemical methods. There were significant
differences between the maximum solubilisation tendencies of PEG5000-DSPE and
PEG2000-DSPE for BUD, which were approximately 605.71±6.38 and 646.27±4.93
μg/ml, respectively. The maximum solubilisation tendencies of PEG5000-DSPE and
PEG2000-DSPE for BDP were approximately 209.65±7.74 and 210.01±5.28,
respectively. These results showed that PEGylated polymers had greater tendencies
to solubilise BUD than BDP. The mean particle sizes at maximum solubilisation of
BUD:PEG2000-DSPE (15.97±1.91 nm) and BDP:PEG2000-DSPE (15.44±1.66 nm)
were smaller than BUD:PEG5000-DSPE (20.45±1.65 nm) and BDP:PEG5000-DSPE
(19.99±0.98 nm). Blank SSMs of PEG5000-DSPE were successfully lyophilised at a
concentration of about 5 mM, while 10 mM of PEG2000-DSPE was needed for
lyophilisation. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Sahib, Mohanad Naji |
| author_facet |
Sahib, Mohanad Naji |
| author_sort |
Sahib, Mohanad Naji |
| title |
Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_short |
Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_full |
Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_fullStr |
Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_full_unstemmed |
Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_sort |
pegylated phospholipid nanomicelles containing budesonide or beclimethasone dipropionate for pulmonary delivery |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2011 |
| url |
http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf |
| _version_ |
1747821647310618624 |