Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation

Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation

Nasopharyngeal carcinoma (NPC) is the third most occurring cancer in Malaysian males, and is unique in its association with Epstein-Barr virus (EBV). LMP-1 is the major oncogenic protein of the EBV. EBV LMP-1 acts by constitutive regulation of host signalling pathways leading to dysregulated cell gr...

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Main Author: Yu, Wei Chiuen
Format: Thesis
Language:English
Published: 2013
Subjects:
R5-920 Medicine (General)
Online Access:http://eprints.usm.my/46351/1/Yu%20Wei%20Chiuen24.pdf
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spelling my-usm-ep.463512020-02-26T05:04:07Z Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation 2013-12 Yu, Wei Chiuen R5-920 Medicine (General) Nasopharyngeal carcinoma (NPC) is the third most occurring cancer in Malaysian males, and is unique in its association with Epstein-Barr virus (EBV). LMP-1 is the major oncogenic protein of the EBV. EBV LMP-1 acts by constitutive regulation of host signalling pathways leading to dysregulated cell growth and has been considered a potential therapeutic target for LMP-1 expressing tumours. LMP-1 is thought to be regulated in its expression as it is not expressed in all NPC tumours. DNA repair proteins are of importance in this context as the status of the function of these proteins has been linked to the process of carcinogenesis. Studies world-wide have shown co-infection of NPC by Human papilloma virus (HPV). The status in Malaysia is not known. In the present study, the importance of viral co-infection in NPC and how it influences the expression of the EBV and host proteins has been evaluated. Fifty seven (57) NPC and twenty seven (27) benign adenoid samples from State of Kelantan in Malaysia were included in this study. Expression of DNA repair proteins such as ATM, DNA-PKcs, Ku70, Ku86, pro and active caspase-3 protein were evaluated immunohistochemically. The viral status of the lesions was evaluated using PCR on extracted DNA from the tumour/benign tissues. Results showed that LMP-1 expression showed a positive correlation with the expression of ATM, and active caspase-3. 2013-12 Thesis http://eprints.usm.my/46351/ http://eprints.usm.my/46351/1/Yu%20Wei%20Chiuen24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
Yu, Wei Chiuen
Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
description Nasopharyngeal carcinoma (NPC) is the third most occurring cancer in Malaysian males, and is unique in its association with Epstein-Barr virus (EBV). LMP-1 is the major oncogenic protein of the EBV. EBV LMP-1 acts by constitutive regulation of host signalling pathways leading to dysregulated cell growth and has been considered a potential therapeutic target for LMP-1 expressing tumours. LMP-1 is thought to be regulated in its expression as it is not expressed in all NPC tumours. DNA repair proteins are of importance in this context as the status of the function of these proteins has been linked to the process of carcinogenesis. Studies world-wide have shown co-infection of NPC by Human papilloma virus (HPV). The status in Malaysia is not known. In the present study, the importance of viral co-infection in NPC and how it influences the expression of the EBV and host proteins has been evaluated. Fifty seven (57) NPC and twenty seven (27) benign adenoid samples from State of Kelantan in Malaysia were included in this study. Expression of DNA repair proteins such as ATM, DNA-PKcs, Ku70, Ku86, pro and active caspase-3 protein were evaluated immunohistochemically. The viral status of the lesions was evaluated using PCR on extracted DNA from the tumour/benign tissues. Results showed that LMP-1 expression showed a positive correlation with the expression of ATM, and active caspase-3.
format Thesis
qualification_level Master's degree
author Yu, Wei Chiuen
author_facet Yu, Wei Chiuen
author_sort Yu, Wei Chiuen
title Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
title_short Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
title_full Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
title_fullStr Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
title_full_unstemmed Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation
title_sort epstein-barr virus latent membrane protein 1 (lmp-1) expression and its association with expression of dna damage repair proteins in nasopharyngeal carcinoma (npc) – an evaluation
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2013
url http://eprints.usm.my/46351/1/Yu%20Wei%20Chiuen24.pdf
_version_ 1747821656841125888

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