Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity

Mosquitoes are important vectors responsible for the transmission of many pathogens that cause major human morbidity and mortality. Aedes aegypti is the main species engaged in the transmission of dengue fever. Natural repellents such as essential oils may provide a means of protection from mosquito...

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Main Author:	Muttiah, Nithya Niranjini
Format:	Thesis
Language:	English
Published:	2019
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/46393/1/Nithya_HJ.pdf
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id	my-usm-ep.46393
record_format	uketd_dc
spelling	my-usm-ep.463932020-02-28T08:17:05Z Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity 2019-08 Muttiah, Nithya Niranjini R5-920 Medicine (General) Mosquitoes are important vectors responsible for the transmission of many pathogens that cause major human morbidity and mortality. Aedes aegypti is the main species engaged in the transmission of dengue fever. Natural repellents such as essential oils may provide a means of protection from mosquito bites that are safer and more pleasant to use. However, their effectiveness decreases relatively fast over time due to high volatility. Nanoemulsion formulation enables to control the volatility of essential oil and thereby extends the duration of repellency. Therefore, oil-in-water nanoemulsion containing the mixture of Jasminum officinale and Anthemis nobilis essential oils were formulated via ultrasonication, and characterised with respect to droplet size, polydispersity index (PDI), zeta potential and storage stability. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygenated monoterpenes and diterpenes constituted 31.14% and 21.20% of J. officinale, respectively. For A. nobilis, oxygenated monoterpenes accounted for 84.79% of the compounds identified. The combination of J. officinale and A. nobilis in a 1:1 ratio exhibited significantly (p < 0.05) higher repellency against Ae. aegypti using a rat model for 120 min than the individual oils. The droplet size of nanoemulsions; nJC1, nJC2 and nJC3 were 264.23, 291.43 and 351.37 nm, respectively. The zeta potential and PDI of the nanoemulsions were -32.77 to -46.93 mV and 0.232 to 0.264, respectively. 2019-08 Thesis http://eprints.usm.my/46393/ http://eprints.usm.my/46393/1/Nithya_HJ.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Muttiah, Nithya Niranjini Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
description	Mosquitoes are important vectors responsible for the transmission of many pathogens that cause major human morbidity and mortality. Aedes aegypti is the main species engaged in the transmission of dengue fever. Natural repellents such as essential oils may provide a means of protection from mosquito bites that are safer and more pleasant to use. However, their effectiveness decreases relatively fast over time due to high volatility. Nanoemulsion formulation enables to control the volatility of essential oil and thereby extends the duration of repellency. Therefore, oil-in-water nanoemulsion containing the mixture of Jasminum officinale and Anthemis nobilis essential oils were formulated via ultrasonication, and characterised with respect to droplet size, polydispersity index (PDI), zeta potential and storage stability. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygenated monoterpenes and diterpenes constituted 31.14% and 21.20% of J. officinale, respectively. For A. nobilis, oxygenated monoterpenes accounted for 84.79% of the compounds identified. The combination of J. officinale and A. nobilis in a 1:1 ratio exhibited significantly (p < 0.05) higher repellency against Ae. aegypti using a rat model for 120 min than the individual oils. The droplet size of nanoemulsions; nJC1, nJC2 and nJC3 were 264.23, 291.43 and 351.37 nm, respectively. The zeta potential and PDI of the nanoemulsions were -32.77 to -46.93 mV and 0.232 to 0.264, respectively.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Muttiah, Nithya Niranjini
author_facet	Muttiah, Nithya Niranjini
author_sort	Muttiah, Nithya Niranjini
title	Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
title_short	Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
title_full	Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
title_fullStr	Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
title_full_unstemmed	Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
title_sort	formulation, characterisation and in vitro skin irritation studies of jasminum officinale and anthemis nobilis essential oil nanoemulsion for aedes aegypti repellent activity
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2019
url	http://eprints.usm.my/46393/1/Nithya_HJ.pdf
_version_	1747821661718052864

Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity

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