Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing

Cinnamon (Cinnamomum zeylanicum) leaf oil contains high percentage of eugenol and has antimicrobial, antioxidant and anti-inflammatory activities. However, the undiluted oil can cause irritation to the skin. Therefore, to avoid irritation cinnamon leaf oils was formulated into nanocream. The nanocre...

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Main Author:	Zainol, Nor Azah
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/46447/1/Nor%20Azah%20Binti%20Zainol24.pdf
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spelling	my-usm-ep.464472020-03-05T08:40:35Z Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing 2014-02 Zainol, Nor Azah RS1-441 Pharmacy and materia medica Cinnamon (Cinnamomum zeylanicum) leaf oil contains high percentage of eugenol and has antimicrobial, antioxidant and anti-inflammatory activities. However, the undiluted oil can cause irritation to the skin. Therefore, to avoid irritation cinnamon leaf oils was formulated into nanocream. The nanocream base was prepared using palm oil, buffer pH 5.5 and surfactants (Tween, Span and Carbitol) at different HLB values of 13.71, 11.13, 9.84 for Tween 80 and Span 65 while 13.92, 12.84 and 10.68 for Tween 80 and Carbitol. Fifteen nanocream base formulations were selected from nanocream areas in three pseudo-ternary phase diagrams, and tested for accelerated stability study. Only four formulations passed the test, and these formulations were modified by adding 2 % cetostearyl alcohol as thickening agent, to improve their stability. The modified formulations were also subjected to accelerated stability test and three formulations passed the test. The nanocream base formulations were characterized in term of droplet size, zeta potential, apparent viscosity, and rheological properties. It was found that the nanocream base B2(2) was the best formulation and 2% cinnamon leaf oil was incorporated to this formulation. The optimized cinnamon leaf oil formulation consists of buffer pH 5.5, oil (96% palm oil, 2% cinnamon leaf oil and 2% cetostearyl alcohol) and surfactants (70% Tween 80 and 30% Span 65 with HLB value 11.13) at the ratio of 47.4:15.8:36.8. 2014-02 Thesis http://eprints.usm.my/46447/ http://eprints.usm.my/46447/1/Nor%20Azah%20Binti%20Zainol24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Zainol, Nor Azah Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
description	Cinnamon (Cinnamomum zeylanicum) leaf oil contains high percentage of eugenol and has antimicrobial, antioxidant and anti-inflammatory activities. However, the undiluted oil can cause irritation to the skin. Therefore, to avoid irritation cinnamon leaf oils was formulated into nanocream. The nanocream base was prepared using palm oil, buffer pH 5.5 and surfactants (Tween, Span and Carbitol) at different HLB values of 13.71, 11.13, 9.84 for Tween 80 and Span 65 while 13.92, 12.84 and 10.68 for Tween 80 and Carbitol. Fifteen nanocream base formulations were selected from nanocream areas in three pseudo-ternary phase diagrams, and tested for accelerated stability study. Only four formulations passed the test, and these formulations were modified by adding 2 % cetostearyl alcohol as thickening agent, to improve their stability. The modified formulations were also subjected to accelerated stability test and three formulations passed the test. The nanocream base formulations were characterized in term of droplet size, zeta potential, apparent viscosity, and rheological properties. It was found that the nanocream base B2(2) was the best formulation and 2% cinnamon leaf oil was incorporated to this formulation. The optimized cinnamon leaf oil formulation consists of buffer pH 5.5, oil (96% palm oil, 2% cinnamon leaf oil and 2% cetostearyl alcohol) and surfactants (70% Tween 80 and 30% Span 65 with HLB value 11.13) at the ratio of 47.4:15.8:36.8.
format	Thesis
qualification_level	Master's degree
author	Zainol, Nor Azah
author_facet	Zainol, Nor Azah
author_sort	Zainol, Nor Azah
title	Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
title_short	Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
title_full	Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
title_fullStr	Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
title_full_unstemmed	Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing
title_sort	development and characterization of eugenol in cinnamon leaf oil nanocream for wound healing
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2014
url	http://eprints.usm.my/46447/1/Nor%20Azah%20Binti%20Zainol24.pdf
_version_	1747821672717615104

Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing

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