Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)

Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)

Sesbania grandiflora, a small tree up to 15 m tall, is a traditional medicinal plant collected from South Lampung, Indonesia. Some new and known compounds were isolated from the roots of this plant. They were identified as one terpenoid, betulinic acid (81), ten flavonoids, malindonesianin A-C (82,...

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Main Author: Noviany, Noviany
Format: Thesis
Language:English
Published: 2014
Subjects:
TP1-1185 Chemical technology
Online Access:http://eprints.usm.my/46449/1/Noviany24.pdf
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spelling my-usm-ep.464492020-03-06T03:02:29Z Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives) 2014-02 Noviany, Noviany TP1-1185 Chemical technology Sesbania grandiflora, a small tree up to 15 m tall, is a traditional medicinal plant collected from South Lampung, Indonesia. Some new and known compounds were isolated from the roots of this plant. They were identified as one terpenoid, betulinic acid (81), ten flavonoids, malindonesianin A-C (82, 86, 88), xenognosin B (83), liquiritigenin (84), 7,2’,4’-trihydroxyisoflavone (85), demethylvestitol (87), vestitol (89), medicarpin (90) and sativan (91), together with one biaryl compound, l,l’-binaphthalene-2,2’-diol (92). Among them, three compounds (82, 86, 88) were established as novel isoflavonoid dimers, while one compound (92) was found as new biaryl natural product. Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was to synthesize 28 new chalcone derivatives compounds by incorporating p-alkoxyacetophenones with substituted benzaldehydes. Four new series of chalcone derivatives have been synthesized using the alkylation and the base catalysed Claisen-Schmidt condensation. All the synthesized compounds were fully characterized by IR, 1D NMR (1H and 13C NMR) and 2D NMR (COSY, HMQC, HMBC) as well as mass spectrometry analysis. 2014-02 Thesis http://eprints.usm.my/46449/ http://eprints.usm.my/46449/1/Noviany24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Kimia
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic TP1-1185 Chemical technology
spellingShingle TP1-1185 Chemical technology
Noviany, Noviany
Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
description Sesbania grandiflora, a small tree up to 15 m tall, is a traditional medicinal plant collected from South Lampung, Indonesia. Some new and known compounds were isolated from the roots of this plant. They were identified as one terpenoid, betulinic acid (81), ten flavonoids, malindonesianin A-C (82, 86, 88), xenognosin B (83), liquiritigenin (84), 7,2’,4’-trihydroxyisoflavone (85), demethylvestitol (87), vestitol (89), medicarpin (90) and sativan (91), together with one biaryl compound, l,l’-binaphthalene-2,2’-diol (92). Among them, three compounds (82, 86, 88) were established as novel isoflavonoid dimers, while one compound (92) was found as new biaryl natural product. Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was to synthesize 28 new chalcone derivatives compounds by incorporating p-alkoxyacetophenones with substituted benzaldehydes. Four new series of chalcone derivatives have been synthesized using the alkylation and the base catalysed Claisen-Schmidt condensation. All the synthesized compounds were fully characterized by IR, 1D NMR (1H and 13C NMR) and 2D NMR (COSY, HMQC, HMBC) as well as mass spectrometry analysis.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Noviany, Noviany
author_facet Noviany, Noviany
author_sort Noviany, Noviany
title Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
title_short Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
title_full Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
title_fullStr Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
title_full_unstemmed Phytochemical Study On Sesbania Grandiflora Roots And Synthesis Of Selected Flavonoid Precursors (Chalcones Derivatives)
title_sort phytochemical study on sesbania grandiflora roots and synthesis of selected flavonoid precursors (chalcones derivatives)
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Kejuruteraan Kimia
publishDate 2014
url http://eprints.usm.my/46449/1/Noviany24.pdf
_version_ 1747821673204154368

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