Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material

A desirable wound dressing should be able to accelerate wound healing with infection controlled effect. Other than that, there are few important features of the wound dressing such as ability to absorb the exudates from wound and to be biodegradable. Therefore, a new blend material was fabricated fr...

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Main Author:	Mathava, Rennukka
Format:	Thesis
Language:	English
Published:	2014
Subjects:	QH1-278.5 Natural history (General)
Online Access:	http://eprints.usm.my/46453/1/Rennukka%20AP%20Mathava24.pdf
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id	my-usm-ep.46453
record_format	uketd_dc
spelling	my-usm-ep.464532020-03-06T08:33:53Z Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material 2014-02 Mathava, Rennukka QH1-278.5 Natural history (General) A desirable wound dressing should be able to accelerate wound healing with infection controlled effect. Other than that, there are few important features of the wound dressing such as ability to absorb the exudates from wound and to be biodegradable. Therefore, a new blend material was fabricated from poly(3- hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and chitosan through simple solvent casting method as they meet the essential requirements of the wound dressing. The impact of different contents of chitosan (5, 10, 15 and 20 wt%) and compositions of 4HB monomer (10, 18, 28 and 44%) towards the properties of hybrid film was determined. The interaction between P(3HB-co-4HB) and chitosan in the form of intermolecular hydrogen bonding was confirmed with the shift in the carbonyl group of copolymer and amide group of chitosan in the FTIR spectra. Film solubility was decreased from 10% to 5% whereas water absorption capacity was increased up to 59-68% when the content of chitosan was 20 wt% in each of the copolymer. Besides, blending with 20 wt% of chitosan improved the elongation at break and lowered the Young’s modulus of the copolymers. In term of thermal properties, depression in the melting temperature and increment of thermal stability were observed. The microscopic images indicated that the blend films had porous and rough surface. Furthermore, they exhibited good inhibition against Escherichia coli (22%) and Staphylococcus aureus (11%). P(3HB-co-4HB)/20 wt% chitosan were more hydrophilic, flexible, porous, rougher and bactericidal. 2014-02 Thesis http://eprints.usm.my/46453/ http://eprints.usm.my/46453/1/Rennukka%20AP%20Mathava24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1-278.5 Natural history (General)
spellingShingle	QH1-278.5 Natural history (General) Mathava, Rennukka Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
description	A desirable wound dressing should be able to accelerate wound healing with infection controlled effect. Other than that, there are few important features of the wound dressing such as ability to absorb the exudates from wound and to be biodegradable. Therefore, a new blend material was fabricated from poly(3- hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and chitosan through simple solvent casting method as they meet the essential requirements of the wound dressing. The impact of different contents of chitosan (5, 10, 15 and 20 wt%) and compositions of 4HB monomer (10, 18, 28 and 44%) towards the properties of hybrid film was determined. The interaction between P(3HB-co-4HB) and chitosan in the form of intermolecular hydrogen bonding was confirmed with the shift in the carbonyl group of copolymer and amide group of chitosan in the FTIR spectra. Film solubility was decreased from 10% to 5% whereas water absorption capacity was increased up to 59-68% when the content of chitosan was 20 wt% in each of the copolymer. Besides, blending with 20 wt% of chitosan improved the elongation at break and lowered the Young’s modulus of the copolymers. In term of thermal properties, depression in the melting temperature and increment of thermal stability were observed. The microscopic images indicated that the blend films had porous and rough surface. Furthermore, they exhibited good inhibition against Escherichia coli (22%) and Staphylococcus aureus (11%). P(3HB-co-4HB)/20 wt% chitosan were more hydrophilic, flexible, porous, rougher and bactericidal.
format	Thesis
qualification_level	Master's degree
author	Mathava, Rennukka
author_facet	Mathava, Rennukka
author_sort	Mathava, Rennukka
title	Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
title_short	Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
title_full	Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
title_fullStr	Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
title_full_unstemmed	Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material
title_sort	fabrication and characterization of poly(3-hydroxybutyrate-co-4- hydroxybutyrate)/chitosan blend and its silver nanocomposite material
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2014
url	http://eprints.usm.my/46453/1/Rennukka%20AP%20Mathava24.pdf
_version_	1747821674184572928

Fabrication And Characterization Of Poly(3-Hydroxybutyrate-Co-4- Hydroxybutyrate)/Chitosan Blend And Its Silver Nanocomposite Material

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