Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_

The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopoly...

Full description

Saved in:

Bibliographic Details
Main Author:	Wong, Wai Yee
Format:	Thesis
Language:	English
Published:	2017
Subjects:	T Technology
Online Access:	http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.46566
record_format	uketd_dc
spelling	my-usm-ep.465662021-11-17T03:42:17Z Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_ 2017-01 Wong, Wai Yee T Technology TA401-492 Materials of engineering and construction. Mechanics of materials The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopolymer coating. Optimum macro- and microporosity in β-TCP scaffold were produced by slurry with ratio 10g:8ml of powder to water and addition of 2 wt. % of PVA and PEG and sintered at 1250°C for 2 hours. The optimum scaffold had 95.3% of porosity with unblock macropore, minimum crack and regular thickness of strut. In the second part, during biopolymer coating, single layer coating with higher PVA concentration had macropores blockage, while lower PVA concentration coating showed uncoated at interior of the scaffold. Bi-layer coating with PLA was to compensate the uncoated interior region in lower PVA concentration coated sample. In terms of mechanical property, compressive strength of the coated scaffold increased with the coated weight percentage of biopolymer. Polymer stretched at the crack opening showed crack bridging mechanism, which toughened the brittle β-TCP scaffold. Scaffold bi-layer coated with 3 wt. % of PVA and subsequently 5 wt. % PLA (V3_L5) had the highest compressive strength (83.7 kPa) with no macropore blocking by biopolymer. In terms of bioactivity, β-TCP without biopolymer coating took 2 weeks to form apatite but V3_L5 took 4 weeks after immersion in SBF. This showed that coating with hydrophobic PLA delayed the time of apatite formation. 2017-01 Thesis http://eprints.usm.my/46566/ http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Wong, Wai Yee Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
description	The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopolymer coating. Optimum macro- and microporosity in β-TCP scaffold were produced by slurry with ratio 10g:8ml of powder to water and addition of 2 wt. % of PVA and PEG and sintered at 1250°C for 2 hours. The optimum scaffold had 95.3% of porosity with unblock macropore, minimum crack and regular thickness of strut. In the second part, during biopolymer coating, single layer coating with higher PVA concentration had macropores blockage, while lower PVA concentration coating showed uncoated at interior of the scaffold. Bi-layer coating with PLA was to compensate the uncoated interior region in lower PVA concentration coated sample. In terms of mechanical property, compressive strength of the coated scaffold increased with the coated weight percentage of biopolymer. Polymer stretched at the crack opening showed crack bridging mechanism, which toughened the brittle β-TCP scaffold. Scaffold bi-layer coated with 3 wt. % of PVA and subsequently 5 wt. % PLA (V3_L5) had the highest compressive strength (83.7 kPa) with no macropore blocking by biopolymer. In terms of bioactivity, β-TCP without biopolymer coating took 2 weeks to form apatite but V3_L5 took 4 weeks after immersion in SBF. This showed that coating with hydrophobic PLA delayed the time of apatite formation.
format	Thesis
qualification_level	Master's degree
author	Wong, Wai Yee
author_facet	Wong, Wai Yee
author_sort	Wong, Wai Yee
title	Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_short	Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_full	Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_fullStr	Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_full_unstemmed	Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_sort	fabrication of 3d porous beta tricalcium phosphate bone scaffold coated by oly(vinyl alcohol) and poly(lactic acid)_
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
publishDate	2017
url	http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf
_version_	1747821686901702656

Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_

Similar Items