Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016

Background: Worldwide, preterm birth remains a significant public health threat in view of its increasing trend and devastating health effects. Similarly, in Malaysia the proportions of preterm birth and related neonatal death were observed to be rising since 2011. However to date, there are limi...

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Main Author:	Damanhuri, Narisa Hatun Ahmad
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/46588/1/Dr.%20Narisa%20Hatun%20Ahmad-Abstract.pdf
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id	my-usm-ep.46588
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spelling	my-usm-ep.465882021-01-27T02:07:06Z Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016 2018-04 Damanhuri, Narisa Hatun Ahmad RG Gynecology and obstetrics Background: Worldwide, preterm birth remains a significant public health threat in view of its increasing trend and devastating health effects. Similarly, in Malaysia the proportions of preterm birth and related neonatal death were observed to be rising since 2011. However to date, there are limited publications on local preterm birth specifically on its characteristics and associated factors. Objectives: The study aimed to investigate on preterm birth in terms of its characteristics and associated factors at HUSM in 2016. Methodology: Retrospective record review on secondary data was conducted by means of a cross-sectional study design in Part I (n=4,246) and a case-control study design in Part II (n=472). Data on mothers attending HUSM for deliveries in 2016 were extracted from the iMOMz database. Descriptive analysis was used in Part I to determine the proportions of preterm births and the proportions of preterm births based on its characteristics (sub-categories, types and neonatal outcomes). Univariate and multivariate analyses were used in Part II to identify the associated factors of preterm birth. Results: The proportion of preterm birth among live births at HUSM in 2016 was 6.5%. All of the preterm births (n=278) fell under the sub-category of moderate to late preterm and predominantly were spontaneous type (74.5%). Only 1.8% of the neonates of these preterm births died within the first 28 days of their lives. The presence of hypertension was significantly associated with preterm birth. Motherswith hypertension had 2.46 higher odds to experience preterm birth compared to mothers with no hypertension when adjusted for mothers with red-tagging (OR=2.46, 95% CI: (1.06, 5.72), p=0.037). Additionally, the presence of red-tagging was also significantly associated with preterm birth. Mothers with red-tagging had 2.06 higher odds to experience preterm birth compared to mothers with no red-tagging when adjusted for mother with hypertension (OR=2.06, 95% CI: (1.37, 3.10), p=0.001). Conclusion: There were significant associations between hypertension and red-tagging with preterm birth. Thus, optimising blood pressure control prior to and during pregnancy as well as preventing the occurrence of pre-eclampsia and its progression to eclampsia are essentially some of the recommended measures, which may improve pregnancy outcomes and reduce the preterm birth rate. In this study however, the model of fitness suggests that it has limited use for prediction. Therefore, future studies need to include all other risk factor variables which were not studied as these variables may improve the internal validity and outcome of studies on predictive risk factors of preterm birth. 2018-04 Thesis http://eprints.usm.my/46588/ http://eprints.usm.my/46588/1/Dr.%20Narisa%20Hatun%20Ahmad-Abstract.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Damanhuri, Narisa Hatun Ahmad Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
description	Background: Worldwide, preterm birth remains a significant public health threat in view of its increasing trend and devastating health effects. Similarly, in Malaysia the proportions of preterm birth and related neonatal death were observed to be rising since 2011. However to date, there are limited publications on local preterm birth specifically on its characteristics and associated factors. Objectives: The study aimed to investigate on preterm birth in terms of its characteristics and associated factors at HUSM in 2016. Methodology: Retrospective record review on secondary data was conducted by means of a cross-sectional study design in Part I (n=4,246) and a case-control study design in Part II (n=472). Data on mothers attending HUSM for deliveries in 2016 were extracted from the iMOMz database. Descriptive analysis was used in Part I to determine the proportions of preterm births and the proportions of preterm births based on its characteristics (sub-categories, types and neonatal outcomes). Univariate and multivariate analyses were used in Part II to identify the associated factors of preterm birth. Results: The proportion of preterm birth among live births at HUSM in 2016 was 6.5%. All of the preterm births (n=278) fell under the sub-category of moderate to late preterm and predominantly were spontaneous type (74.5%). Only 1.8% of the neonates of these preterm births died within the first 28 days of their lives. The presence of hypertension was significantly associated with preterm birth. Motherswith hypertension had 2.46 higher odds to experience preterm birth compared to mothers with no hypertension when adjusted for mothers with red-tagging (OR=2.46, 95% CI: (1.06, 5.72), p=0.037). Additionally, the presence of red-tagging was also significantly associated with preterm birth. Mothers with red-tagging had 2.06 higher odds to experience preterm birth compared to mothers with no red-tagging when adjusted for mother with hypertension (OR=2.06, 95% CI: (1.37, 3.10), p=0.001). Conclusion: There were significant associations between hypertension and red-tagging with preterm birth. Thus, optimising blood pressure control prior to and during pregnancy as well as preventing the occurrence of pre-eclampsia and its progression to eclampsia are essentially some of the recommended measures, which may improve pregnancy outcomes and reduce the preterm birth rate. In this study however, the model of fitness suggests that it has limited use for prediction. Therefore, future studies need to include all other risk factor variables which were not studied as these variables may improve the internal validity and outcome of studies on predictive risk factors of preterm birth.
format	Thesis
qualification_level	Master's degree
author	Damanhuri, Narisa Hatun Ahmad
author_facet	Damanhuri, Narisa Hatun Ahmad
author_sort	Damanhuri, Narisa Hatun Ahmad
title	Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
title_short	Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
title_full	Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
title_fullStr	Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
title_full_unstemmed	Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016
title_sort	characteristics and associated factors of preterm birth at hospital universiti sains malaysia (husm) in 2016
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46588/1/Dr.%20Narisa%20Hatun%20Ahmad-Abstract.pdf
_version_	1747821691601420288

Characteristics and associated factors of preterm birth at Hospital Universiti Sains Malaysia (HUSM) in 2016

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