Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application

Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively studied for various biomedical applications, such as magnetic resonance imaging (MRI) contrast agents, and hyperthermia. The most common approach used to produce SPIONs is co-precipitation method. However, problem due to agglo...

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Main Author:	Noqta, Osama Ahmad Salameh Abu
Format:	Thesis
Language:	English
Published:	2018
Subjects:	QC1 Physics (General)
Online Access:	http://eprints.usm.my/46676/1/Osama%20Ahmad%20Salameh%20Abu%20Noqta24.pdf
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spelling	my-usm-ep.466762020-07-03T07:17:42Z Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application 2018-12 Noqta, Osama Ahmad Salameh Abu QC1 Physics (General) Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively studied for various biomedical applications, such as magnetic resonance imaging (MRI) contrast agents, and hyperthermia. The most common approach used to produce SPIONs is co-precipitation method. However, problem due to agglomeration and the broad size distribution of nanoparticles prepared by co-precipitation method hinder their application progress in MRI. Therefore, this study aims to produce a highly stabilized and monodispersed SPIONs for MRI contrast agents. In this thesis, SPIONs were synthesized with different surfactants (tri-sodium citrate, polyvinylpyrrolidone (PVP), chitosan, cetyl trimethylammonium bromide (CTAB) and citric acid) using the one pot co-precipitation method for surface modification and to ensure excellent colloidal stability in water. In addition, the synthesis parameters such as surfactant concentration, pH, and temperature of reaction were optimized to obtain stabilized SPIONs. The SPIONs prepared in the presence of tri-sodium citrate formed the most stable SPIONs due to improved physiological condition, dispersion and stabilization in aqueous solution. In addition, citrate-SPIONs displayed the highest zeta potential (ζ= -44.0 mV) and saturation magnetization (Ms=53.9 emu g-1) compared with other samples, due to the ability of three carboxylate groups dissociated from the citrate to strongly bind to the surface of SPIONs. The TEM measurements of the different SPIONs indicated that the type of surfactant affects their average particle sizes and size distribution. In addition, the presence of defects within the spinel structure, i.e., oxidation of the SPIONs, seems to be also influenced by the choice of surfactant. 2018-12 Thesis http://eprints.usm.my/46676/ http://eprints.usm.my/46676/1/Osama%20Ahmad%20Salameh%20Abu%20Noqta24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1 Physics (General)
spellingShingle	QC1 Physics (General) Noqta, Osama Ahmad Salameh Abu Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
description	Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively studied for various biomedical applications, such as magnetic resonance imaging (MRI) contrast agents, and hyperthermia. The most common approach used to produce SPIONs is co-precipitation method. However, problem due to agglomeration and the broad size distribution of nanoparticles prepared by co-precipitation method hinder their application progress in MRI. Therefore, this study aims to produce a highly stabilized and monodispersed SPIONs for MRI contrast agents. In this thesis, SPIONs were synthesized with different surfactants (tri-sodium citrate, polyvinylpyrrolidone (PVP), chitosan, cetyl trimethylammonium bromide (CTAB) and citric acid) using the one pot co-precipitation method for surface modification and to ensure excellent colloidal stability in water. In addition, the synthesis parameters such as surfactant concentration, pH, and temperature of reaction were optimized to obtain stabilized SPIONs. The SPIONs prepared in the presence of tri-sodium citrate formed the most stable SPIONs due to improved physiological condition, dispersion and stabilization in aqueous solution. In addition, citrate-SPIONs displayed the highest zeta potential (ζ= -44.0 mV) and saturation magnetization (Ms=53.9 emu g-1) compared with other samples, due to the ability of three carboxylate groups dissociated from the citrate to strongly bind to the surface of SPIONs. The TEM measurements of the different SPIONs indicated that the type of surfactant affects their average particle sizes and size distribution. In addition, the presence of defects within the spinel structure, i.e., oxidation of the SPIONs, seems to be also influenced by the choice of surfactant.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Noqta, Osama Ahmad Salameh Abu
author_facet	Noqta, Osama Ahmad Salameh Abu
author_sort	Noqta, Osama Ahmad Salameh Abu
title	Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
title_short	Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
title_full	Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
title_fullStr	Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
title_full_unstemmed	Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application
title_sort	characterization of superparamagnetic iron oxide nanoparticles with different surfactants - in search of optimum synthesis parameters for mri application
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Fizik
publishDate	2018
url	http://eprints.usm.my/46676/1/Osama%20Ahmad%20Salameh%20Abu%20Noqta24.pdf
_version_	1747821710379319296

Characterization Of Superparamagnetic Iron Oxide Nanoparticles With Different Surfactants - In Search Of Optimum Synthesis Parameters For Mri Application

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