Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter

Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explor...

Full description

Saved in:

Bibliographic Details
Main Author:	Azis, Nazihah
Format:	Thesis
Language:	English
Published:	2018
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.46691
record_format	uketd_dc
spelling	my-usm-ep.466912020-07-07T07:16:17Z Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter 2018 Azis, Nazihah RC799-869 Diseases of the digestive system. Gastroenterology Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explored the expression of TRPV4 as a causative factor and the link between pH study and manometry. This knowledge is beneficial for new targeted treatment. Methodology This was a prospective study that was done on NERD and control patients from March 2017 until November 2017. A total of 55 patients - 39 NERD and 16 control patients were investigated. All patients had undergone EGD and multiple biopsies were taken. Notably, erosive esophagitis patients were excluded. Apart from that, the patients also went through pH study and manometry. Results The result from this research we showed that TRPV4 was expressed in both NERD and control patients. No association was discovered between TRPV4 and NERD, as well as among pH study, manometry and endoscopic features. Futhermore, TRPV4 was found to be higher in cells from the normal group as compared to the NERD group. Notably, p-value was insignificant but this may be caused by small sample size Conclusion This study was performed to determine the association between TRPV4 and NERD. No significant association was revealed between the expression of of TRPV 4 and the NERD group. Similarly, other parameters from pH study, manometry and endoscopic finding also did not show any significant association with TRPV4. 2018 Thesis http://eprints.usm.my/46691/ http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Azis, Nazihah Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
description	Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explored the expression of TRPV4 as a causative factor and the link between pH study and manometry. This knowledge is beneficial for new targeted treatment. Methodology This was a prospective study that was done on NERD and control patients from March 2017 until November 2017. A total of 55 patients - 39 NERD and 16 control patients were investigated. All patients had undergone EGD and multiple biopsies were taken. Notably, erosive esophagitis patients were excluded. Apart from that, the patients also went through pH study and manometry. Results The result from this research we showed that TRPV4 was expressed in both NERD and control patients. No association was discovered between TRPV4 and NERD, as well as among pH study, manometry and endoscopic features. Futhermore, TRPV4 was found to be higher in cells from the normal group as compared to the NERD group. Notably, p-value was insignificant but this may be caused by small sample size Conclusion This study was performed to determine the association between TRPV4 and NERD. No significant association was revealed between the expression of of TRPV 4 and the NERD group. Similarly, other parameters from pH study, manometry and endoscopic finding also did not show any significant association with TRPV4.
format	Thesis
qualification_level	Master's degree
author	Azis, Nazihah
author_facet	Azis, Nazihah
author_sort	Azis, Nazihah
title	Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_short	Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_full	Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_fullStr	Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_full_unstemmed	Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_sort	expression of transient receptor potential vanilloid 4 (trpv4) in nerd vs normal control and association with ph study and manometry parameter
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf
_version_	1747821713568038912

Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter

Similar Items