Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection

The wide-ranging use of pesticides causes concern for their effect on human as well as animal life, which is in direct and indirect contact with hazardous compounds through pesticide build-up in food and drinking water. Therefore, this study aimed of the outmost importance to develop methods and tec...

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Main Author:	Lah, Nuur Fahanis Che
Format:	Thesis
Language:	English
Published:	2019
Subjects:	T Technology TP155-156 Chemical engineering
Online Access:	http://eprints.usm.my/46860/1/Atrazine-Based%20Molecularly%20Imprinted%20Polymer%20As%20Electrochemical%20Sensor%20For%20Pesticide%20Detection.pdf
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spelling	my-usm-ep.468602021-11-17T03:42:12Z Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection 2019-02-01 Lah, Nuur Fahanis Che T Technology TP155-156 Chemical engineering The wide-ranging use of pesticides causes concern for their effect on human as well as animal life, which is in direct and indirect contact with hazardous compounds through pesticide build-up in food and drinking water. Therefore, this study aimed of the outmost importance to develop methods and techniques for atrazine detection in aqueous solutions. Highly crosslinked polymers have been prepared by precipitation polymerization using high monomer loadings (≥ 25 v/v %) which generally lead to bulk monolith. The formulation of the polymer was modified by varying the Methacrylic Acid (MAA) as the monomer and Ethylene Glycol Dimethacrylate (EDGMA) as the crosslinker ratio together with several types of porogenic solvent. It was observed that the formulation of 1:15:40 (Atr:EDGMA:MAA) with 5% of Dimethyl Sulfoxide (DMSO) and 95% of toluene as the porogen mixture improves the efficiency of the imprinted polymer compared to the formulation in 100% of toluene. The binding capacity increase for almost 18% from the original formulation. Two distinct morphologies were observed. Monodispersed microspheres were obtained using toluene whereas segmented irregular particles were formed with DMSO. The ratio of monomer, crosslinker and the type of solvent mixture were identified as influential parameters on the particle morphology. The adsorption equilibrium data showed that the imprinted polymer resulted in the lowers error for Jovanovic isotherm model. The adsorption kinetics of atrazine on MIPs was studied and found to fit the best with Lagergen first order kinetic model. The optimum formulation of imprinted polymer was assembled with graphite felt electrode as the transduction for electrochemical analysis. Cyclic voltammetry (CV) and electrochemical impedance spectrum (EIS) were used to characterize the sensor and investigate the electrochemical response of the sensor. The heterogeneous electron transfer constant, k0 that was calculated from CV indicates that the constant fall between the quasi reversible system with 0.0661 cm.s-1 for anodic and 0.0195 cm.s-1 for cathodic. The limit of detection (LOD) for the system was found to be at 4.99 nM. An equivalent circuit was suggested from the Nyquist plot that gives good fits with χ2 value between 0.6298 and 1.475 interpret the process of molecule diffusion from the bulk solution onto the electrode surface by quantitatively analyse each component of the sensor system. With the proposed methodology, electrochemical atrazine-based molecular imprinted polymers (MIPs) sensor have been prepared successfully in high monomer concentration with the improvement by manipulating the porogen/solvent mixture. 2019-02 Thesis http://eprints.usm.my/46860/ http://eprints.usm.my/46860/1/Atrazine-Based%20Molecularly%20Imprinted%20Polymer%20As%20Electrochemical%20Sensor%20For%20Pesticide%20Detection.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology TP155-156 Chemical engineering
spellingShingle	T Technology TP155-156 Chemical engineering Lah, Nuur Fahanis Che Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
description	The wide-ranging use of pesticides causes concern for their effect on human as well as animal life, which is in direct and indirect contact with hazardous compounds through pesticide build-up in food and drinking water. Therefore, this study aimed of the outmost importance to develop methods and techniques for atrazine detection in aqueous solutions. Highly crosslinked polymers have been prepared by precipitation polymerization using high monomer loadings (≥ 25 v/v %) which generally lead to bulk monolith. The formulation of the polymer was modified by varying the Methacrylic Acid (MAA) as the monomer and Ethylene Glycol Dimethacrylate (EDGMA) as the crosslinker ratio together with several types of porogenic solvent. It was observed that the formulation of 1:15:40 (Atr:EDGMA:MAA) with 5% of Dimethyl Sulfoxide (DMSO) and 95% of toluene as the porogen mixture improves the efficiency of the imprinted polymer compared to the formulation in 100% of toluene. The binding capacity increase for almost 18% from the original formulation. Two distinct morphologies were observed. Monodispersed microspheres were obtained using toluene whereas segmented irregular particles were formed with DMSO. The ratio of monomer, crosslinker and the type of solvent mixture were identified as influential parameters on the particle morphology. The adsorption equilibrium data showed that the imprinted polymer resulted in the lowers error for Jovanovic isotherm model. The adsorption kinetics of atrazine on MIPs was studied and found to fit the best with Lagergen first order kinetic model. The optimum formulation of imprinted polymer was assembled with graphite felt electrode as the transduction for electrochemical analysis. Cyclic voltammetry (CV) and electrochemical impedance spectrum (EIS) were used to characterize the sensor and investigate the electrochemical response of the sensor. The heterogeneous electron transfer constant, k0 that was calculated from CV indicates that the constant fall between the quasi reversible system with 0.0661 cm.s-1 for anodic and 0.0195 cm.s-1 for cathodic. The limit of detection (LOD) for the system was found to be at 4.99 nM. An equivalent circuit was suggested from the Nyquist plot that gives good fits with χ2 value between 0.6298 and 1.475 interpret the process of molecule diffusion from the bulk solution onto the electrode surface by quantitatively analyse each component of the sensor system. With the proposed methodology, electrochemical atrazine-based molecular imprinted polymers (MIPs) sensor have been prepared successfully in high monomer concentration with the improvement by manipulating the porogen/solvent mixture.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Lah, Nuur Fahanis Che
author_facet	Lah, Nuur Fahanis Che
author_sort	Lah, Nuur Fahanis Che
title	Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
title_short	Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
title_full	Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
title_fullStr	Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
title_full_unstemmed	Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection
title_sort	atrazine-based molecularly imprinted polymer as electrochemical sensor for pesticide detection
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Kimia
publishDate	2019
url	http://eprints.usm.my/46860/1/Atrazine-Based%20Molecularly%20Imprinted%20Polymer%20As%20Electrochemical%20Sensor%20For%20Pesticide%20Detection.pdf
_version_	1747821737820553216

Atrazine-Based Molecularly Imprinted Polymer As Electrochemical Sensor For Pesticide Detection

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