In vitro effect of ganoderma lucidum extracts on hematological parameter

Thrombosis is a pathologic condition that occurs when the body forms arterial or venous blood clots that are excessively large and obstruct blood flow. Heart attack, stroke or pulmonary embolism are examples of conditions when develop in blood vessels which may contribute to various symptoms and...

Full description

Saved in:

Bibliographic Details
Main Author:	Ismail, Che Shuraya Che
Format:	Thesis
Language:	English
Published:	2005
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/47047/1/PTA...Che%20Suraya%20Binti%20Che%20Ismail...2005...-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.47047
record_format	uketd_dc
spelling	my-usm-ep.470472020-09-01T08:25:56Z In vitro effect of ganoderma lucidum extracts on hematological parameter 2005-03 Ismail, Che Shuraya Che R Medicine Thrombosis is a pathologic condition that occurs when the body forms arterial or venous blood clots that are excessively large and obstruct blood flow. Heart attack, stroke or pulmonary embolism are examples of conditions when develop in blood vessels which may contribute to various symptoms and complications. Therefore the search for an effective agent that can secure full antithrombotic benefits while minimizing the antihaemostatic outcome should be pursued. In this study, in order to assess the effect of Ganoderma lucidum in inhibition of platelet aggregation, two types of extract were prepared from crude powder of commercially available products of Ganoderma lucidum. Both the two types of extracts were tested for their activities on blood cells in vitro. The effects of this mushroom were tested based on the changes in hematological parameters following the treatment with different doses of water and ethanol extract Ganoderma Jucidum using hematology analyzer (Abbott Celldyn 4000). The test duration for the observation was set for 2 hours and the observation were made every 30 minutes intervals. From this study, the results showed that there were no significant difference of effect between different doses of water and ethanol extracts on MPV. However, there were significant differences of the effect of extracts of Ganoderma lucidum in different concentration on MPV at different time intervals. Antiplatelet aggregation activities by indirect evaluation of changes in blood cells parameters in vitro following the treatment with Ganoderma Jucidum extract may not be fully explored or elucidated by the in vitro study. However, theresults from this preliminary study will assist in establishing the direction of an in vivo study, which will be followed. In order to look at the activities of platelet and the effects on other hematological parameters in vivo, a long-term prospective study should be explored to prove the potential use of Ganoderma lucidum mushroom as a prophylactic agent for prevents arterial thrombosis. 2005-03 Thesis http://eprints.usm.my/47047/ http://eprints.usm.my/47047/1/PTA...Che%20Suraya%20Binti%20Che%20Ismail...2005...-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kesihatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Ismail, Che Shuraya Che In vitro effect of ganoderma lucidum extracts on hematological parameter
description	Thrombosis is a pathologic condition that occurs when the body forms arterial or venous blood clots that are excessively large and obstruct blood flow. Heart attack, stroke or pulmonary embolism are examples of conditions when develop in blood vessels which may contribute to various symptoms and complications. Therefore the search for an effective agent that can secure full antithrombotic benefits while minimizing the antihaemostatic outcome should be pursued. In this study, in order to assess the effect of Ganoderma lucidum in inhibition of platelet aggregation, two types of extract were prepared from crude powder of commercially available products of Ganoderma lucidum. Both the two types of extracts were tested for their activities on blood cells in vitro. The effects of this mushroom were tested based on the changes in hematological parameters following the treatment with different doses of water and ethanol extract Ganoderma Jucidum using hematology analyzer (Abbott Celldyn 4000). The test duration for the observation was set for 2 hours and the observation were made every 30 minutes intervals. From this study, the results showed that there were no significant difference of effect between different doses of water and ethanol extracts on MPV. However, there were significant differences of the effect of extracts of Ganoderma lucidum in different concentration on MPV at different time intervals. Antiplatelet aggregation activities by indirect evaluation of changes in blood cells parameters in vitro following the treatment with Ganoderma Jucidum extract may not be fully explored or elucidated by the in vitro study. However, theresults from this preliminary study will assist in establishing the direction of an in vivo study, which will be followed. In order to look at the activities of platelet and the effects on other hematological parameters in vivo, a long-term prospective study should be explored to prove the potential use of Ganoderma lucidum mushroom as a prophylactic agent for prevents arterial thrombosis.
format	Thesis
qualification_level	Master's degree
author	Ismail, Che Shuraya Che
author_facet	Ismail, Che Shuraya Che
author_sort	Ismail, Che Shuraya Che
title	In vitro effect of ganoderma lucidum extracts on hematological parameter
title_short	In vitro effect of ganoderma lucidum extracts on hematological parameter
title_full	In vitro effect of ganoderma lucidum extracts on hematological parameter
title_fullStr	In vitro effect of ganoderma lucidum extracts on hematological parameter
title_full_unstemmed	In vitro effect of ganoderma lucidum extracts on hematological parameter
title_sort	in vitro effect of ganoderma lucidum extracts on hematological parameter
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kesihatan
publishDate	2005
url	http://eprints.usm.my/47047/1/PTA...Che%20Suraya%20Binti%20Che%20Ismail...2005...-24%20pages.pdf
_version_	1747821751819042816

In vitro effect of ganoderma lucidum extracts on hematological parameter

Similar Items