Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications

This study attempted to clarify the influence of induced sensitivity on the structural, physicochemical, drug loading and release profiles of chitosan built hydrogel for controlled drug delivery applications. Different series of hydrogel based on free radical copolymerization of chitosan with poly (...

Full description

Saved in:

Bibliographic Details
Main Author:	Ullah, Faheem
Format:	Thesis
Language:	English
Published:	2018
Subjects:	T Technology
Online Access:	http://eprints.usm.my/47316/1/Synthesis%2C%20Characterization%20And%20Physicochemical%20Investigations%20Of%20Chitosan%20Built%20Hydrogel%20For%20Controlled%20Drug%20Delivery%20Applications.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.47316
record_format	uketd_dc
spelling	my-usm-ep.473162021-11-17T03:42:13Z Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications 2018-08-01 Ullah, Faheem T Technology TA401-492 Materials of engineering and construction. Mechanics of materials This study attempted to clarify the influence of induced sensitivity on the structural, physicochemical, drug loading and release profiles of chitosan built hydrogel for controlled drug delivery applications. Different series of hydrogel based on free radical copolymerization of chitosan with poly (ethylene glycol) methyl ether methacrylate, acrylamide-co- methacrylic acid and alginic acid were synthesized and functionalized with induced micellization, glucose sensitivity and hydrophilicity for extended interfaces with drug solutions. The overall hydrogel were characterized by using different techniques as FT-IR, 13C-NMR, SEM, AFM, TGA, DSC, DLS and UV-Visible spectroscopy. The effect of various stimuli (pH, glucose, temperature, ionic strength, urea) on physicochemical properties and the in vitro drug loading versus release profiles of various model drugs from the hydrogel matrices was investigated at physiological conditions. The results suggested that the molecular weight of chitosan does not effect the Critical Micelle Concentration (CMC) and Lower Critical Solution Temperature (LCST). The morphology of hydrogel Analyzed by SEM and AFM analysis revealed hydrogel with high internal surface areas resulted with low diffusional resistance. The model drugs Fluorescein, Rhodamine and Bromocresol green with 75.94%, 65.63% and 76% release profiles were obtained due to electrostatic complexation and extended interfaces of selective ligands with drug solutions. The drug release was observed due to concentration gradient, core to surface and surface to aqueous medium by diffusion and were detected spectroscopically. The diffusion coefficeint (n≈ 0.7) suggested Non- Fickian mechanism of drug release through water diffusion and hydrogel relaxation. In vitro degradation of 20% and 38% was achieved for hydrogel with induced hydrophilicity in simulated gastric and intestinal fluids for 400 h (2 weeks) through bulk erosion. Therefore, this study contributes to the knowledge of chitosan built hydrogel as high performance biomaterials designed for controlled drug delivery applications. 2018-08 Thesis http://eprints.usm.my/47316/ http://eprints.usm.my/47316/1/Synthesis%2C%20Characterization%20And%20Physicochemical%20Investigations%20Of%20Chitosan%20Built%20Hydrogel%20For%20Controlled%20Drug%20Delivery%20Applications.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Ullah, Faheem Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
description	This study attempted to clarify the influence of induced sensitivity on the structural, physicochemical, drug loading and release profiles of chitosan built hydrogel for controlled drug delivery applications. Different series of hydrogel based on free radical copolymerization of chitosan with poly (ethylene glycol) methyl ether methacrylate, acrylamide-co- methacrylic acid and alginic acid were synthesized and functionalized with induced micellization, glucose sensitivity and hydrophilicity for extended interfaces with drug solutions. The overall hydrogel were characterized by using different techniques as FT-IR, 13C-NMR, SEM, AFM, TGA, DSC, DLS and UV-Visible spectroscopy. The effect of various stimuli (pH, glucose, temperature, ionic strength, urea) on physicochemical properties and the in vitro drug loading versus release profiles of various model drugs from the hydrogel matrices was investigated at physiological conditions. The results suggested that the molecular weight of chitosan does not effect the Critical Micelle Concentration (CMC) and Lower Critical Solution Temperature (LCST). The morphology of hydrogel Analyzed by SEM and AFM analysis revealed hydrogel with high internal surface areas resulted with low diffusional resistance. The model drugs Fluorescein, Rhodamine and Bromocresol green with 75.94%, 65.63% and 76% release profiles were obtained due to electrostatic complexation and extended interfaces of selective ligands with drug solutions. The drug release was observed due to concentration gradient, core to surface and surface to aqueous medium by diffusion and were detected spectroscopically. The diffusion coefficeint (n≈ 0.7) suggested Non- Fickian mechanism of drug release through water diffusion and hydrogel relaxation. In vitro degradation of 20% and 38% was achieved for hydrogel with induced hydrophilicity in simulated gastric and intestinal fluids for 400 h (2 weeks) through bulk erosion. Therefore, this study contributes to the knowledge of chitosan built hydrogel as high performance biomaterials designed for controlled drug delivery applications.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ullah, Faheem
author_facet	Ullah, Faheem
author_sort	Ullah, Faheem
title	Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
title_short	Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
title_full	Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
title_fullStr	Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
title_full_unstemmed	Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications
title_sort	synthesis, characterization and physicochemical investigations of chitosan built hydrogel for controlled drug delivery applications
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
publishDate	2018
url	http://eprints.usm.my/47316/1/Synthesis%2C%20Characterization%20And%20Physicochemical%20Investigations%20Of%20Chitosan%20Built%20Hydrogel%20For%20Controlled%20Drug%20Delivery%20Applications.pdf
_version_	1747821760863010816

Synthesis, Characterization And Physicochemical Investigations Of Chitosan Built Hydrogel For Controlled Drug Delivery Applications

Similar Items