Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone

The nano-sized B-type magnesium-silicon carbonated hydroxyapatite (Mg-Si CHA) powders was successfully synthesized by nanoemulsion method through direct pouring (DP) technique at ambient temperature. Magnesium (Mg) and silicon (Si) were substituted into the carbonated hydroxyapatite (CHA) lattice st...

Full description

Saved in:

Bibliographic Details
Main Author:	Zainudin, Harmiza
Format:	Thesis
Language:	English
Published:	2018
Subjects:	T Technology
Online Access:	http://eprints.usm.my/47390/1/Effect%20Of%20Magnesium-Silicon%20Substitution%20On%20The%20Characteristics%20Of%20Carbonated%20Hydroxyapatite%20For%20Synthetic%20Bone.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.47390
record_format	uketd_dc
spelling	my-usm-ep.473902021-11-17T03:42:14Z Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone 2018-03-01 Zainudin, Harmiza T Technology TA401-492 Materials of engineering and construction. Mechanics of materials The nano-sized B-type magnesium-silicon carbonated hydroxyapatite (Mg-Si CHA) powders was successfully synthesized by nanoemulsion method through direct pouring (DP) technique at ambient temperature. Magnesium (Mg) and silicon (Si) were substituted into the carbonated hydroxyapatite (CHA) lattice structure in order to mimic the chemical composition of the human natural bone. The Mg-Si CHA particles exhibit angular or near spherical-like in shape with the dimension of 10-40 nm (length) and 5-20 nm (width). The incorporation of less than 1% of Mg and Si into the CHA lattice appears to have no direct effect on the phase composition, as evidenced by X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) results. Sintering was then performed on the Mg-Si CHA sample at 800°C and 2 hours soaking. During the cooling stage, the sintered sample was taken out from the furnace when the temperature reaches 200°C and placed in a desiccators. Wet carbon dioxide gas (CO2) was pumped into the desiccators to compensate the carbonate loss during sintering. The carbonate content of sintered Mg-Si CHA was 6.80%, which is fall in the range typically reported for natural bone (3 to 8%). In vitro bioactivity of the Mg-Si CHA was evaluated through immersion sample in simulated body fluid (SBF) solution as a medium and cytotoxicity test in term of cell culture response. The results revealed that the Mg-Si CHA had good bioactivity by rapid apatite formation ability and found to be non-cytotoxic on the human fibroblast, as demonstrated by high cell viabilities. In conclusion, Mg-Si CHA may be used as a synthetic bone substitution material. 2018-03 Thesis http://eprints.usm.my/47390/ http://eprints.usm.my/47390/1/Effect%20Of%20Magnesium-Silicon%20Substitution%20On%20The%20Characteristics%20Of%20Carbonated%20Hydroxyapatite%20For%20Synthetic%20Bone.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Zainudin, Harmiza Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
description	The nano-sized B-type magnesium-silicon carbonated hydroxyapatite (Mg-Si CHA) powders was successfully synthesized by nanoemulsion method through direct pouring (DP) technique at ambient temperature. Magnesium (Mg) and silicon (Si) were substituted into the carbonated hydroxyapatite (CHA) lattice structure in order to mimic the chemical composition of the human natural bone. The Mg-Si CHA particles exhibit angular or near spherical-like in shape with the dimension of 10-40 nm (length) and 5-20 nm (width). The incorporation of less than 1% of Mg and Si into the CHA lattice appears to have no direct effect on the phase composition, as evidenced by X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) results. Sintering was then performed on the Mg-Si CHA sample at 800°C and 2 hours soaking. During the cooling stage, the sintered sample was taken out from the furnace when the temperature reaches 200°C and placed in a desiccators. Wet carbon dioxide gas (CO2) was pumped into the desiccators to compensate the carbonate loss during sintering. The carbonate content of sintered Mg-Si CHA was 6.80%, which is fall in the range typically reported for natural bone (3 to 8%). In vitro bioactivity of the Mg-Si CHA was evaluated through immersion sample in simulated body fluid (SBF) solution as a medium and cytotoxicity test in term of cell culture response. The results revealed that the Mg-Si CHA had good bioactivity by rapid apatite formation ability and found to be non-cytotoxic on the human fibroblast, as demonstrated by high cell viabilities. In conclusion, Mg-Si CHA may be used as a synthetic bone substitution material.
format	Thesis
qualification_level	Master's degree
author	Zainudin, Harmiza
author_facet	Zainudin, Harmiza
author_sort	Zainudin, Harmiza
title	Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
title_short	Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
title_full	Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
title_fullStr	Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
title_full_unstemmed	Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone
title_sort	effect of magnesium-silicon substitution on the characteristics of carbonated hydroxyapatite for synthetic bone
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral
publishDate	2018
url	http://eprints.usm.my/47390/1/Effect%20Of%20Magnesium-Silicon%20Substitution%20On%20The%20Characteristics%20Of%20Carbonated%20Hydroxyapatite%20For%20Synthetic%20Bone.pdf
_version_	1747821767948238848

Effect Of Magnesium-Silicon Substitution On The Characteristics Of Carbonated Hydroxyapatite For Synthetic Bone

Similar Items