A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion

Objective: 1. To determine the specificity and sensitivity of the criterias of the tumour vascularity pattern using power Doppler sonography in differentiating benign and malignant breast lesion. 2. To find any association between tumour vascularity pattern and size of benign and malignant brea...

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Main Author:	Said, Siti Nor Badriati Sheik
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/47395/1/Power%20Doppler%20Sonography%20Using%20Tumor%20Vascularity%20Pattern%20In%20Differentiating%20Bening%20From%20Malignant%20Breast%20Lesion...2006...mka..-24%20pages.pdf
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spelling	my-usm-ep.473952020-09-24T01:31:39Z A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion 2006 Said, Siti Nor Badriati Sheik RC31-1245 Internal medicine Objective: 1. To determine the specificity and sensitivity of the criterias of the tumour vascularity pattern using power Doppler sonography in differentiating benign and malignant breast lesion. 2. To find any association between tumour vascularity pattern and size of benign and malignant breast lesion Methods and Materials: Ethics committee approval and informed consent were obtained. This study was carried out in Hospital USM, Kubang Kerian, Kelantan for 16 months from July 2004 until October 2005. Power Doppler sonography using 13.5MHz transducer was prospectively performed on a total of 40 patients with breast lesion. The tumour vascularity criterias assessed were the flow, distribution, vessel morphology and presence of penetrating artery. FNAC (Fine needle aspiration cytology) and/or HPE (Histopathological examination) were done for all cases. The power Doppler criterias and HPE were analysed using univariate analysis. The sensitivity, specificity, positive predictive value and negative predictive value calculated using diagnostic table. Result: There was detectable blood flow in 13 infiltrating ductal CA and 16 benign lesions. The mean size of vascular lesion was 30.5mm with 1.8mm standard deviation. The size of the lesions may have played a part in the vascularity of the lesion with a p value of 0.005 for flow characteristics. In the vascular lesions, irregular vessel and presence of penetrating artery showed a significant p value of 0.004 and 0.0 11. There was no single vascularity pattern which was specific for benign and malignant breast lesion. The descriptors of vessel morphology, flow, distribution and penetrating artery were not found to be highly predictive of malignancy with positive predictive value of 50. 0%, 54.5%, 56.0% and 63.1% respectively. High negative predictive values were interestingly noted in the following descriptors: peripheral distribution (100%), low flow (88.9%) and regular vessel (87.5%). Conclusion: Power Doppler US provided only limited additional information in differentiating benign solid breast lesions from malignant lesions. Vascular assessment was helpful only when it supported a benign morphology. 2006 Thesis http://eprints.usm.my/47395/ http://eprints.usm.my/47395/1/Power%20Doppler%20Sonography%20Using%20Tumor%20Vascularity%20Pattern%20In%20Differentiating%20Bening%20From%20Malignant%20Breast%20Lesion...2006...mka..-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Said, Siti Nor Badriati Sheik A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
description	Objective: 1. To determine the specificity and sensitivity of the criterias of the tumour vascularity pattern using power Doppler sonography in differentiating benign and malignant breast lesion. 2. To find any association between tumour vascularity pattern and size of benign and malignant breast lesion Methods and Materials: Ethics committee approval and informed consent were obtained. This study was carried out in Hospital USM, Kubang Kerian, Kelantan for 16 months from July 2004 until October 2005. Power Doppler sonography using 13.5MHz transducer was prospectively performed on a total of 40 patients with breast lesion. The tumour vascularity criterias assessed were the flow, distribution, vessel morphology and presence of penetrating artery. FNAC (Fine needle aspiration cytology) and/or HPE (Histopathological examination) were done for all cases. The power Doppler criterias and HPE were analysed using univariate analysis. The sensitivity, specificity, positive predictive value and negative predictive value calculated using diagnostic table. Result: There was detectable blood flow in 13 infiltrating ductal CA and 16 benign lesions. The mean size of vascular lesion was 30.5mm with 1.8mm standard deviation. The size of the lesions may have played a part in the vascularity of the lesion with a p value of 0.005 for flow characteristics. In the vascular lesions, irregular vessel and presence of penetrating artery showed a significant p value of 0.004 and 0.0 11. There was no single vascularity pattern which was specific for benign and malignant breast lesion. The descriptors of vessel morphology, flow, distribution and penetrating artery were not found to be highly predictive of malignancy with positive predictive value of 50. 0%, 54.5%, 56.0% and 63.1% respectively. High negative predictive values were interestingly noted in the following descriptors: peripheral distribution (100%), low flow (88.9%) and regular vessel (87.5%). Conclusion: Power Doppler US provided only limited additional information in differentiating benign solid breast lesions from malignant lesions. Vascular assessment was helpful only when it supported a benign morphology.
format	Thesis
qualification_level	Master's degree
author	Said, Siti Nor Badriati Sheik
author_facet	Said, Siti Nor Badriati Sheik
author_sort	Said, Siti Nor Badriati Sheik
title	A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
title_short	A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
title_full	A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
title_fullStr	A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
title_full_unstemmed	A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
title_sort	pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2006
url	http://eprints.usm.my/47395/1/Power%20Doppler%20Sonography%20Using%20Tumor%20Vascularity%20Pattern%20In%20Differentiating%20Bening%20From%20Malignant%20Breast%20Lesion...2006...mka..-24%20pages.pdf
_version_	1747821768434778112

A pilot study of power doppler sonography using tumour vascularity pattern in differentiating benign from malignant breast lesion

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