Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study

Introduction Kacip Fatimah is a traditional herb that contains phytoestrogen and is commonly used by the Malay population in Malaysia to treat various gynecological illnesses. It is also used as an alternative to hormone replacement therapy due to its estrogenic effect. Postmenopausal hormone us...

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Main Author:	Keat, Tan Boon
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/47645/1/DR.%20TAN%20BOON%20KEAT-24%20pages.pdf
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id	my-usm-ep.47645
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spelling	my-usm-ep.476452020-10-21T02:03:49Z Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study 2006-11 Keat, Tan Boon RG Gynecology and obstetrics Introduction Kacip Fatimah is a traditional herb that contains phytoestrogen and is commonly used by the Malay population in Malaysia to treat various gynecological illnesses. It is also used as an alternative to hormone replacement therapy due to its estrogenic effect. Postmenopausal hormone use is associated with increase in mammographic density and mammographic density is an independent risk factor for breast cancer. Objective Our purpose was to evaluate the effect of Kacip Fatimah (Labisia pumila) water extract on mammographic density in postmenopausal women. Material and Method A prospective, randomized, double-blind placebo-controlled pilot study was conducted. A total of 69 postmenopausal women were equally randomized to receive Kacip Fatimah water extract 140 mg/day, 280 mg/day, 560 mg/day or placebo. Mammograms were performed at baseline and after 6 months of treatment. Mammographic density was evaluated according to percentage scale, BIRAD classification and computer assisted measurement of breast density. Result The categorical assessments showed that there was no significant shift in categorical classification as assessed by BIRAD and percentage categories in either control or treatment groups. There was slight increase in breast density as assessed by computer assisted method although the increases were not statistically significant. The increases in breast density over pretreatment baseline were 0.2 °/o, 0.1 %, 1.5 % and 0.6 % for placebo, 140 mg group, 280 mg group and 560 mg group, respectively. These values were not significantly different from one another. This small increase in breast density might be due to the fact that phytoestrogen is a weak estrogen. Conclusion Kacip Fatimah extract given over a period of 6 months did not significantly affect mammographic density. 2006-11 Thesis http://eprints.usm.my/47645/ http://eprints.usm.my/47645/1/DR.%20TAN%20BOON%20KEAT-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Keat, Tan Boon Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
description	Introduction Kacip Fatimah is a traditional herb that contains phytoestrogen and is commonly used by the Malay population in Malaysia to treat various gynecological illnesses. It is also used as an alternative to hormone replacement therapy due to its estrogenic effect. Postmenopausal hormone use is associated with increase in mammographic density and mammographic density is an independent risk factor for breast cancer. Objective Our purpose was to evaluate the effect of Kacip Fatimah (Labisia pumila) water extract on mammographic density in postmenopausal women. Material and Method A prospective, randomized, double-blind placebo-controlled pilot study was conducted. A total of 69 postmenopausal women were equally randomized to receive Kacip Fatimah water extract 140 mg/day, 280 mg/day, 560 mg/day or placebo. Mammograms were performed at baseline and after 6 months of treatment. Mammographic density was evaluated according to percentage scale, BIRAD classification and computer assisted measurement of breast density. Result The categorical assessments showed that there was no significant shift in categorical classification as assessed by BIRAD and percentage categories in either control or treatment groups. There was slight increase in breast density as assessed by computer assisted method although the increases were not statistically significant. The increases in breast density over pretreatment baseline were 0.2 °/o, 0.1 %, 1.5 % and 0.6 % for placebo, 140 mg group, 280 mg group and 560 mg group, respectively. These values were not significantly different from one another. This small increase in breast density might be due to the fact that phytoestrogen is a weak estrogen. Conclusion Kacip Fatimah extract given over a period of 6 months did not significantly affect mammographic density.
format	Thesis
qualification_level	Master's degree
author	Keat, Tan Boon
author_facet	Keat, Tan Boon
author_sort	Keat, Tan Boon
title	Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
title_short	Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
title_full	Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
title_fullStr	Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
title_full_unstemmed	Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
title_sort	effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2006
url	http://eprints.usm.my/47645/1/DR.%20TAN%20BOON%20KEAT-24%20pages.pdf
_version_	1747821812917469184

Effect on kacip fatimah (labisia pumila) water extract on mamographic density- a pilot study

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