A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus

Objective : The purpose of this study is to see whether there was any significant difference in arterial stiffness (as measured by augmentation index) between diabetic and non diabetic subjects and to see whether there was any significant difference between two different oral hypoglycaemic agents...

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Main Author:	Hassan, Noor Hasliza
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RC648-665 Diseases of the endocrine glands Clinical endocrinology
Online Access:	http://eprints.usm.my/47741/1/Dr.%20Noor%20Hasliza%20Hassan-24%20pages.pdf
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id	my-usm-ep.47741
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spelling	my-usm-ep.477412020-10-25T07:30:59Z A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus 2006 Hassan, Noor Hasliza RC648-665 Diseases of the endocrine glands. Clinical endocrinology Objective : The purpose of this study is to see whether there was any significant difference in arterial stiffness (as measured by augmentation index) between diabetic and non diabetic subjects and to see whether there was any significant difference between two different oral hypoglycaemic agents(OHA) regimens, (sulphonylurea monotherapy and metformin in combination with sulphonylurea therapy) on arterial stiffness. Methods : This was a case control study conducted in the Klinik rawatan keluarga(KRK) and Diabetic clinic, HUSM from May 2004 till May 2005. Hundred and two diabetic subjects and hundred and two age- and sex-matched non-diabetic control subjects were recruited after obtaining verbal consent following explanation of study protocol. Augmentation index (AI) was measured using the Sphygmocor apparatus and all measurements were performed by the researcher after an earlier validation study. These mean augmentation index measurements were then analyzed. Result : The mean of AI of diabetic subjects was significantly higher than non diabetic subjects ( 140.32 ± 12.0% Vs 128.77 ± 10.69%, P < 0.0001 ). However, therewas no significant difference in mean AI between two different OHA regimen groups in diabetic subjects (140.51 ± 11.42 Vs 140.14 ± 12.86, 95% CI: -4.40, 5.15, p = 0.877). Conclusion: Diabetic patients have increased arterial stiffness compared with age- and sex-matched non diabetic subjects, which may partly explain why diabetes mellitus are associated with increased cardiovascular risk. This study also showed that two different groups of oral hypoglycaemic agents have no effect in relation to arterial stiffness. 2006 Thesis http://eprints.usm.my/47741/ http://eprints.usm.my/47741/1/Dr.%20Noor%20Hasliza%20Hassan-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC648-665 Diseases of the endocrine glands Clinical endocrinology
spellingShingle	RC648-665 Diseases of the endocrine glands Clinical endocrinology Hassan, Noor Hasliza A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
description	Objective : The purpose of this study is to see whether there was any significant difference in arterial stiffness (as measured by augmentation index) between diabetic and non diabetic subjects and to see whether there was any significant difference between two different oral hypoglycaemic agents(OHA) regimens, (sulphonylurea monotherapy and metformin in combination with sulphonylurea therapy) on arterial stiffness. Methods : This was a case control study conducted in the Klinik rawatan keluarga(KRK) and Diabetic clinic, HUSM from May 2004 till May 2005. Hundred and two diabetic subjects and hundred and two age- and sex-matched non-diabetic control subjects were recruited after obtaining verbal consent following explanation of study protocol. Augmentation index (AI) was measured using the Sphygmocor apparatus and all measurements were performed by the researcher after an earlier validation study. These mean augmentation index measurements were then analyzed. Result : The mean of AI of diabetic subjects was significantly higher than non diabetic subjects ( 140.32 ± 12.0% Vs 128.77 ± 10.69%, P < 0.0001 ). However, therewas no significant difference in mean AI between two different OHA regimen groups in diabetic subjects (140.51 ± 11.42 Vs 140.14 ± 12.86, 95% CI: -4.40, 5.15, p = 0.877). Conclusion: Diabetic patients have increased arterial stiffness compared with age- and sex-matched non diabetic subjects, which may partly explain why diabetes mellitus are associated with increased cardiovascular risk. This study also showed that two different groups of oral hypoglycaemic agents have no effect in relation to arterial stiffness.
format	Thesis
qualification_level	Master's degree
author	Hassan, Noor Hasliza
author_facet	Hassan, Noor Hasliza
author_sort	Hassan, Noor Hasliza
title	A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
title_short	A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
title_full	A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
title_fullStr	A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
title_full_unstemmed	A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
title_sort	study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2006
url	http://eprints.usm.my/47741/1/Dr.%20Noor%20Hasliza%20Hassan-24%20pages.pdf
_version_	1747821823650693120

A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus

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