Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of...
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2018
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my-usm-ep.477972020-10-27T09:24:48Z Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice 2018-01 Kumar, Venugopalan Santhosh QR Microbiology Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. 2018-01 Thesis http://eprints.usm.my/47797/ http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
QR Microbiology |
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QR Microbiology Kumar, Venugopalan Santhosh Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| description |
Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane,
chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Kumar, Venugopalan Santhosh |
| author_facet |
Kumar, Venugopalan Santhosh |
| author_sort |
Kumar, Venugopalan Santhosh |
| title |
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_short |
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_full |
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_fullStr |
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_full_unstemmed |
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_sort |
potential immunomodulating activity of neem (azadirachta indica) leaf extracts and its bioactive compound n-acetylglucosamine in mice |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) |
| publishDate |
2018 |
| url |
http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf |
| _version_ |
1747821831680688128 |