Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice

Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of...

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主要作者: Kumar, Venugopalan Santhosh
格式: Thesis
语言:English
出版: 2018
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spelling my-usm-ep.477972020-10-27T09:24:48Z Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice 2018-01 Kumar, Venugopalan Santhosh QR Microbiology Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. 2018-01 Thesis http://eprints.usm.my/47797/ http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QR Microbiology
spellingShingle QR Microbiology
Kumar, Venugopalan Santhosh
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
description Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Kumar, Venugopalan Santhosh
author_facet Kumar, Venugopalan Santhosh
author_sort Kumar, Venugopalan Santhosh
title Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_short Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_full Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_fullStr Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_full_unstemmed Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_sort potential immunomodulating activity of neem (azadirachta indica) leaf extracts and its bioactive compound n-acetylglucosamine in mice
granting_institution Universiti Sains Malaysia
granting_department Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research)
publishDate 2018
url http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf
_version_ 1747821831680688128