Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)

Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl a...

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主要作者:	Nowroji, Kavitha
格式:	Thesis
语言:	English
出版:	2017
主题:	RA1190-1270 Toxicology Poisons
在线阅读:	http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf
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id	my-usm-ep.47820
record_format	uketd_dc
spelling	my-usm-ep.478202020-10-28T06:48:40Z Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf) 2017-12 Nowroji, Kavitha RA1190-1270 Toxicology. Poisons Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl acetate fraction (PMEAF). Total phenolic content of PMEAF was expressed as 14.91 ± 0.97 mg GAE/g. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and CyQuant Cell Proliferation assay results indicated that PMEAF is a potential anticancer agent with the average IC50 values of 18.10 μg/mL. 2017-12 Thesis http://eprints.usm.my/47820/ http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORM)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RA1190-1270 Toxicology Poisons
spellingShingle	RA1190-1270 Toxicology Poisons Nowroji, Kavitha Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
description	Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl acetate fraction (PMEAF). Total phenolic content of PMEAF was expressed as 14.91 ± 0.97 mg GAE/g. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and CyQuant Cell Proliferation assay results indicated that PMEAF is a potential anticancer agent with the average IC50 values of 18.10 μg/mL.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Nowroji, Kavitha
author_facet	Nowroji, Kavitha
author_sort	Nowroji, Kavitha
title	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_short	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_full	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_fullStr	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_full_unstemmed	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_sort	study of cytotoxic mechanism and the role of microrna in mda-mb-231 cell lines treated with phaleria macrocarpa (boerl.) fruit ethyl acetate fraction (pmeaf)
granting_institution	Universiti Sains Malaysia
granting_department	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORM)
publishDate	2017
url	http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf
_version_	1747821835342315520

Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)

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