In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model

Banxia Tianma Baizhu Tang (BBT) is one of the most common Traditional Chinese Medicine (TCM) used for treating hypertension. However, differences in the herbs’ geographical location, time of harvest and processing when compared to ancient times has warranted modification in the formula. Although mod...

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Main Author:	Tan, Chu Shan
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/48056/1/IN%20VIVO%20ANTIHYPERTENSIVE%20AND%20IN%20VITRO.pdf%20cut.pdf
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id	my-usm-ep.48056
record_format	uketd_dc
spelling	my-usm-ep.480562021-01-08T02:29:33Z In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model 2017-11 Tan, Chu Shan RS1-441 Pharmacy and materia medica Banxia Tianma Baizhu Tang (BBT) is one of the most common Traditional Chinese Medicine (TCM) used for treating hypertension. However, differences in the herbs’ geographical location, time of harvest and processing when compared to ancient times has warranted modification in the formula. Although modification of BBT have been previously done (by addition of one or two other herbs in BBT), optimal reformulation of BBT for anti-hypertension has not been carried out. The authenticities of six raw herbs of BBT were verified by high performance thin layer chromatography (HPTLC) and Fourier transform infrared (FTIR) fingerprints identification methods. Three solvents (95%, 50% ethanol and water) were used for maceration process. The vasodilatory effects of all extracts were investigated by using the in vitro isolated aortic rings assays. Among the extracts, water extract of P. ternata [PT(W)] and C. reticulatae [CR(W)], 50% ethanol extract of G. elata [GE(50)] and G. uralensis [GU(50)], and 95% ethanol extract of A. macrocephala [AM(95)] and P. cocos [PC(95)] were found as the most potent extracts for exerting vasodilatory effects. 2017-11 Thesis http://eprints.usm.my/48056/ http://eprints.usm.my/48056/1/IN%20VIVO%20ANTIHYPERTENSIVE%20AND%20IN%20VITRO.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Tan, Chu Shan In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
description	Banxia Tianma Baizhu Tang (BBT) is one of the most common Traditional Chinese Medicine (TCM) used for treating hypertension. However, differences in the herbs’ geographical location, time of harvest and processing when compared to ancient times has warranted modification in the formula. Although modification of BBT have been previously done (by addition of one or two other herbs in BBT), optimal reformulation of BBT for anti-hypertension has not been carried out. The authenticities of six raw herbs of BBT were verified by high performance thin layer chromatography (HPTLC) and Fourier transform infrared (FTIR) fingerprints identification methods. Three solvents (95%, 50% ethanol and water) were used for maceration process. The vasodilatory effects of all extracts were investigated by using the in vitro isolated aortic rings assays. Among the extracts, water extract of P. ternata [PT(W)] and C. reticulatae [CR(W)], 50% ethanol extract of G. elata [GE(50)] and G. uralensis [GU(50)], and 95% ethanol extract of A. macrocephala [AM(95)] and P. cocos [PC(95)] were found as the most potent extracts for exerting vasodilatory effects.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Tan, Chu Shan
author_facet	Tan, Chu Shan
author_sort	Tan, Chu Shan
title	In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
title_short	In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
title_full	In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
title_fullStr	In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
title_full_unstemmed	In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model
title_sort	in vivo antihypertensive and in vitro vasodilatory studies of reformulated banxia baizhu tianma tang: pharmacological optimisation using orthogonal stimulus-response compatibility model
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate	2017
url	http://eprints.usm.my/48056/1/IN%20VIVO%20ANTIHYPERTENSIVE%20AND%20IN%20VITRO.pdf%20cut.pdf
_version_	1747821873690836992

In Vivo Antihypertensive And In Vitro Vasodilatory Studies Of Reformulated Banxia Baizhu Tianma Tang: Pharmacological Optimisation Using Orthogonal Stimulus-Response Compatibility Model

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