Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease

The target in treatment of periodontal disease is to eliminate the pathogens responsible for infection and decrease the tissue inflammation. Treatment using non-surgical scaling and root planning could leave behind microorganisms leading to re-colonization. Administration of anti-microbial and anti-...

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Main Author:	Wadi, Nida Mohammed Ali
Format:	Thesis
Language:	English
Published:	2019
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/48220/1/Nida%20Mohammed%20Ali%20Wadi%20cut.pdf
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id	my-usm-ep.48220
record_format	uketd_dc
spelling	my-usm-ep.482202021-02-01T02:09:51Z Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease 2019-05 Wadi, Nida Mohammed Ali RS1-441 Pharmacy and materia medica The target in treatment of periodontal disease is to eliminate the pathogens responsible for infection and decrease the tissue inflammation. Treatment using non-surgical scaling and root planning could leave behind microorganisms leading to re-colonization. Administration of anti-microbial and anti-inflammatory drugs orally, even at therapeutic doses in patients leads to some side effects. Local administration of drugs obviates the drawbacks of other routes of administration. The study was aimed to develop a syringeable, bioadhesive, sustained release, thermosensitive in situ gelling formulation of metronidazole and diclofenac potassium for the treatment of periodontal disease, which was delivered directly to the site of action. A simple HPLC-UV method that could simultaneously determine metronidazole and diclofenac potassium concentrations was developed and validated. The method was specific, precise and accurate. The two drug peaks were well resolved with good resolution. The sample run time was less than 12 min. The method was applied in drug assay, in vitro drug release study, in vitro drug permeation study and stability study of the gel formulations. Poloxamers 407 and 188 were used to prepare the in situ gelling formulations. Poloxamer of 30%w/w (poloxamer 407 and 188 at ratio of 2:1) showed gelation temperature close to the physiological temperature of the oral cavity. Xanthan gum and Carbopol 934 were incorporated to provide bioadhesive properties and sustain the drug release. 2019-05 Thesis http://eprints.usm.my/48220/ http://eprints.usm.my/48220/1/Nida%20Mohammed%20Ali%20Wadi%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Wadi, Nida Mohammed Ali Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
description	The target in treatment of periodontal disease is to eliminate the pathogens responsible for infection and decrease the tissue inflammation. Treatment using non-surgical scaling and root planning could leave behind microorganisms leading to re-colonization. Administration of anti-microbial and anti-inflammatory drugs orally, even at therapeutic doses in patients leads to some side effects. Local administration of drugs obviates the drawbacks of other routes of administration. The study was aimed to develop a syringeable, bioadhesive, sustained release, thermosensitive in situ gelling formulation of metronidazole and diclofenac potassium for the treatment of periodontal disease, which was delivered directly to the site of action. A simple HPLC-UV method that could simultaneously determine metronidazole and diclofenac potassium concentrations was developed and validated. The method was specific, precise and accurate. The two drug peaks were well resolved with good resolution. The sample run time was less than 12 min. The method was applied in drug assay, in vitro drug release study, in vitro drug permeation study and stability study of the gel formulations. Poloxamers 407 and 188 were used to prepare the in situ gelling formulations. Poloxamer of 30%w/w (poloxamer 407 and 188 at ratio of 2:1) showed gelation temperature close to the physiological temperature of the oral cavity. Xanthan gum and Carbopol 934 were incorporated to provide bioadhesive properties and sustain the drug release.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Wadi, Nida Mohammed Ali
author_facet	Wadi, Nida Mohammed Ali
author_sort	Wadi, Nida Mohammed Ali
title	Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
title_short	Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
title_full	Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
title_fullStr	Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
title_full_unstemmed	Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease
title_sort	development and evaluation of bioadhesive, thermosensitive, in situ gelling formulation of metronidazole and diclofenac potassium for treatment of periodontal disease
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2019
url	http://eprints.usm.my/48220/1/Nida%20Mohammed%20Ali%20Wadi%20cut.pdf
_version_	1747821904769581056

Development And Evaluation Of Bioadhesive, Thermosensitive, In Situ Gelling Formulation Of Metronidazole And Diclofenac Potassium For Treatment Of Periodontal Disease

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