Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis

Periodontitis is a highly prevalent major dental disease that affects millions of people around the globe. Anaerobic gram-negative bacteria and its toxins have been strongly implicated as a prime cause of the disease. A great number of local drug delivery systems have been proposed, but they were ma...

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Main Author:	Nafiu, Aminu
Format:	Thesis
Language:	English
Published:	2019
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/48541/1/Full%20Final%20Draft%20Thesis_Nafiu%20cut.pdf
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id	my-usm-ep.48541
record_format	uketd_dc
spelling	my-usm-ep.485412021-03-08T04:38:48Z Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis 2019-03 Nafiu, Aminu RS1-441 Pharmacy and materia medica Periodontitis is a highly prevalent major dental disease that affects millions of people around the globe. Anaerobic gram-negative bacteria and its toxins have been strongly implicated as a prime cause of the disease. A great number of local drug delivery systems have been proposed, but they were mainly made to focus on killing the causative microbes rather than also targeting the inflammation which also plays a significant role in the aetiology of the disease. Moreover, there is difficulty in accessing the periodontal pocket and attaining adequate residence time by these systems, hence being only partially successful. Therefore, the aim of this study was to formulate and evaluate a novel biocompatible nanogel (NG) co-loaded with triclosan (TCS) and flurbiprofen (FLB) for effective intra-pocket treatment of periodontitis. TCS and FLB are highly crystalline compounds and practically insoluble in water. These properties restrict delivery of their pure forms into the periodontal pocket, hence warranted their formulation into a nanoparticulate system. HPLC method development, compatibility study, nanoparticles (NPs) and NG development were performed. The formulations were extensively characterised by scanning electron microscopy (SEM), transmission electron microscopy (TEM), particle size, polydispersity index (PDI), zeta potential, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), fourier transform infrared spectroscopy (FTIR), rheology, swelling, erosion, bioadhesion, in vitro release, antimicrobial, stability and in vivo studies. The developed HPLC method was able to successfully separate and quantify TCS and FLB at retention times (tR) of 12.5 and 10.1 min, respectively. 2019-03 Thesis http://eprints.usm.my/48541/ http://eprints.usm.my/48541/1/Full%20Final%20Draft%20Thesis_Nafiu%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Nafiu, Aminu Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
description	Periodontitis is a highly prevalent major dental disease that affects millions of people around the globe. Anaerobic gram-negative bacteria and its toxins have been strongly implicated as a prime cause of the disease. A great number of local drug delivery systems have been proposed, but they were mainly made to focus on killing the causative microbes rather than also targeting the inflammation which also plays a significant role in the aetiology of the disease. Moreover, there is difficulty in accessing the periodontal pocket and attaining adequate residence time by these systems, hence being only partially successful. Therefore, the aim of this study was to formulate and evaluate a novel biocompatible nanogel (NG) co-loaded with triclosan (TCS) and flurbiprofen (FLB) for effective intra-pocket treatment of periodontitis. TCS and FLB are highly crystalline compounds and practically insoluble in water. These properties restrict delivery of their pure forms into the periodontal pocket, hence warranted their formulation into a nanoparticulate system. HPLC method development, compatibility study, nanoparticles (NPs) and NG development were performed. The formulations were extensively characterised by scanning electron microscopy (SEM), transmission electron microscopy (TEM), particle size, polydispersity index (PDI), zeta potential, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), fourier transform infrared spectroscopy (FTIR), rheology, swelling, erosion, bioadhesion, in vitro release, antimicrobial, stability and in vivo studies. The developed HPLC method was able to successfully separate and quantify TCS and FLB at retention times (tR) of 12.5 and 10.1 min, respectively.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Nafiu, Aminu
author_facet	Nafiu, Aminu
author_sort	Nafiu, Aminu
title	Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
title_short	Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
title_full	Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
title_fullStr	Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
title_full_unstemmed	Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis
title_sort	development and evaluation of nanogel system loaded with triclosan and flurbiprofen for treatment of periodontitis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2019
url	http://eprints.usm.my/48541/1/Full%20Final%20Draft%20Thesis_Nafiu%20cut.pdf
_version_	1747821943060430848

Development And Evaluation Of Nanogel System Loaded With Triclosan And Flurbiprofen For Treatment Of Periodontitis

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