Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan

Pakistan is ranked 11 among the high tuberculosis (TB) burden countries where TB is rated 6th of top 10 causes of mortality. Although, the national guidelines for the diagnosis and management of TB in children were established in 2007, but little is known about the management and treatment outcom...

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主要作者: Laghari, Madeeha
格式: Thesis
语言:English
出版: 2018
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spelling my-usm-ep.485522021-03-08T07:20:30Z Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan 2018-07 Laghari, Madeeha RC306-320.5 Tuberculosis Pakistan is ranked 11 among the high tuberculosis (TB) burden countries where TB is rated 6th of top 10 causes of mortality. Although, the national guidelines for the diagnosis and management of TB in children were established in 2007, but little is known about the management and treatment outcomes of childhood TB in Pakistan. For this purpose, children treated under Directly Observed Treatment Short course (DOTS) at (5) multicentre hospitals of Sindh were recruited as cohort in this observational study. Total 2,167 children were registered during retrospective phase from 2011 to 2015 and for prospective phase from 1st June 2016 to 30th November 2016, 508 children were enrolled with TB at the study site. During the study period, childhood TB accounted 12.2% of all TB cases in Hyderabad, Jamshoro and Matiari districts. In the present study, 12.1% were bacteriologically confirmed sputum smear positive cases. At the end of intensive phase, 79.3% of patients achieved sputum smear conversion. Patients who had household contacts with TB and experienced adverse effects were significantly less likely to achieve sputum conversion and were more likely to become sputum positive during the treatment. Around 13.2% of patients came across with adverse effects. In multivariate analysis females and children with previous treatment were at greater risk to develop adverse effects due to anti-TB drugs. The overall treatment success rate was recorded as 93%. Rural residents, sputum smear positive, children with previous treatment, those who had ADRs and household contacts with TB emerged as predictors for unsuccessful treatment outcomes. 2018-07 Thesis http://eprints.usm.my/48552/ http://eprints.usm.my/48552/1/MADEEHA%20LAGHARI_hj.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RC306-320.5 Tuberculosis
spellingShingle RC306-320.5 Tuberculosis
Laghari, Madeeha
Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
description Pakistan is ranked 11 among the high tuberculosis (TB) burden countries where TB is rated 6th of top 10 causes of mortality. Although, the national guidelines for the diagnosis and management of TB in children were established in 2007, but little is known about the management and treatment outcomes of childhood TB in Pakistan. For this purpose, children treated under Directly Observed Treatment Short course (DOTS) at (5) multicentre hospitals of Sindh were recruited as cohort in this observational study. Total 2,167 children were registered during retrospective phase from 2011 to 2015 and for prospective phase from 1st June 2016 to 30th November 2016, 508 children were enrolled with TB at the study site. During the study period, childhood TB accounted 12.2% of all TB cases in Hyderabad, Jamshoro and Matiari districts. In the present study, 12.1% were bacteriologically confirmed sputum smear positive cases. At the end of intensive phase, 79.3% of patients achieved sputum smear conversion. Patients who had household contacts with TB and experienced adverse effects were significantly less likely to achieve sputum conversion and were more likely to become sputum positive during the treatment. Around 13.2% of patients came across with adverse effects. In multivariate analysis females and children with previous treatment were at greater risk to develop adverse effects due to anti-TB drugs. The overall treatment success rate was recorded as 93%. Rural residents, sputum smear positive, children with previous treatment, those who had ADRs and household contacts with TB emerged as predictors for unsuccessful treatment outcomes.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Laghari, Madeeha
author_facet Laghari, Madeeha
author_sort Laghari, Madeeha
title Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
title_short Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
title_full Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
title_fullStr Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
title_full_unstemmed Childhood Tuberculosis: Evaluation Of Clinical Outcomes And Treatment Compliance In Multicenter Hospitals Of Sindh, Pakistan
title_sort childhood tuberculosis: evaluation of clinical outcomes and treatment compliance in multicenter hospitals of sindh, pakistan
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2018
url http://eprints.usm.my/48552/1/MADEEHA%20LAGHARI_hj.pdf
_version_ 1747821945512001536