A Multifactorial Analysis Of Association Between Cytokine Levels And Patients With Autoantibodies Anti-Ro/La From Northern Region Of Malaysia
Connective tissue diseases (CTDs) are one of the common autoimmune diseases (AIDs) in many countries and always associated with high levels of autoantibody anti-Ro and anti-La. The current study was conducted to determine the multifactorial analysis of association between pro- and anti- inflammat...
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my-usm-ep.490182021-04-26T07:27:04Z A Multifactorial Analysis Of Association Between Cytokine Levels And Patients With Autoantibodies Anti-Ro/La From Northern Region Of Malaysia 2019-08 Zubir, Anisah Abdul QH1 Natural history (General - Including nature conservation, geographical distribution) Connective tissue diseases (CTDs) are one of the common autoimmune diseases (AIDs) in many countries and always associated with high levels of autoantibody anti-Ro and anti-La. The current study was conducted to determine the multifactorial analysis of association between pro- and anti- inflammatory cytokines, interleukin (IL)-6 & IL-10 respectively in sera of female positive anti-Ro or anti-La or both in northern Malaysia. Multiple factors including medication and menopause status were analyzed from samples diagnosed with CTD at different disease onset. Serum samples were collected from government hospitals in northern region Malaysia. Serum samples were screened for CTD using enzyme immunoassay (EIA). Presence of anti-nuclear antibody (ANA) patterns was tested by indirect immunofluorescence assay (IFA). Speckled IFA pattern was tested for anti-Ro and anti-La by EIA. Levels of IL-6 and IL-10 were measured using ELISA. Our findings showed that the mean age of positive anti-Ro or anti-La in female of Northern Malaysia was 38.1 years (SD±15.01) (n=106). Malay female represented the highest frequency of positive anti-Ro and anti-la autoantibodies compared to Chinese, Indian and other races in North Malaysia (72.6% vs. 17.0%, 7.5%, 2.8%). There are no significant associations between cytokine levels with medicines taken and hormonal status (p>0.05). However, result indicated that 97.4% of patients diagnosed with autoimmune-CTD were managed with steroid-based therapy. 2019-08 Thesis http://eprints.usm.my/49018/ http://eprints.usm.my/49018/1/ANISAH%20ABDUL%20ZUBIR_M.Sc.Thesis%202019%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
QH1 Natural history (General - Including nature conservation geographical distribution) |
| spellingShingle |
QH1 Natural history (General - Including nature conservation geographical distribution) Zubir, Anisah Abdul A Multifactorial Analysis Of Association Between Cytokine Levels And Patients With Autoantibodies Anti-Ro/La From Northern Region Of Malaysia |
| description |
Connective tissue diseases (CTDs) are one of the common autoimmune
diseases (AIDs) in many countries and always associated with high levels of
autoantibody anti-Ro and anti-La. The current study was conducted to determine the
multifactorial analysis of association between pro- and anti- inflammatory cytokines,
interleukin (IL)-6 & IL-10 respectively in sera of female positive anti-Ro or anti-La
or both in northern Malaysia. Multiple factors including medication and menopause
status were analyzed from samples diagnosed with CTD at different disease onset.
Serum samples were collected from government hospitals in northern region
Malaysia. Serum samples were screened for CTD using enzyme immunoassay (EIA).
Presence of anti-nuclear antibody (ANA) patterns was tested by indirect
immunofluorescence assay (IFA). Speckled IFA pattern was tested for anti-Ro and
anti-La by EIA. Levels of IL-6 and IL-10 were measured using ELISA. Our findings
showed that the mean age of positive anti-Ro or anti-La in female of Northern
Malaysia was 38.1 years (SD±15.01) (n=106). Malay female represented the highest
frequency of positive anti-Ro and anti-la autoantibodies compared to Chinese, Indian
and other races in North Malaysia (72.6% vs. 17.0%, 7.5%, 2.8%). There are no
significant associations between cytokine levels with medicines taken and hormonal
status (p>0.05). However, result indicated that 97.4% of patients diagnosed with
autoimmune-CTD were managed with steroid-based therapy. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Zubir, Anisah Abdul |
| author_facet |
Zubir, Anisah Abdul |
| author_sort |
Zubir, Anisah Abdul |
| title |
A Multifactorial Analysis Of
Association Between Cytokine Levels
And Patients With Autoantibodies
Anti-Ro/La From Northern Region Of
Malaysia |
| title_short |
A Multifactorial Analysis Of
Association Between Cytokine Levels
And Patients With Autoantibodies
Anti-Ro/La From Northern Region Of
Malaysia |
| title_full |
A Multifactorial Analysis Of
Association Between Cytokine Levels
And Patients With Autoantibodies
Anti-Ro/La From Northern Region Of
Malaysia |
| title_fullStr |
A Multifactorial Analysis Of
Association Between Cytokine Levels
And Patients With Autoantibodies
Anti-Ro/La From Northern Region Of
Malaysia |
| title_full_unstemmed |
A Multifactorial Analysis Of
Association Between Cytokine Levels
And Patients With Autoantibodies
Anti-Ro/La From Northern Region Of
Malaysia |
| title_sort |
multifactorial analysis of
association between cytokine levels
and patients with autoantibodies
anti-ro/la from northern region of
malaysia |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Kajihayat |
| publishDate |
2019 |
| url |
http://eprints.usm.my/49018/1/ANISAH%20ABDUL%20ZUBIR_M.Sc.Thesis%202019%20cut.pdf |
| _version_ |
1747821976585502720 |