Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia

Background: Perioperative red blood cell (RBC) transfusion in coronary artery bypass grafting (CABG) has both benefits and harms. Our aim was to study the association between perioperative RBC transfusion and its adverse outcomes in patients who underwent isolated CABG. Methods: This was a retro...

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Main Author:	Hua, Chan Choon
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RD Surgery
Online Access:	http://eprints.usm.my/49358/1/Chan%20Choon%20Hua-24%20pages.pdf
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spelling	my-usm-ep.493582021-06-27T15:10:11Z Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia 2020 Hua, Chan Choon RD Surgery Background: Perioperative red blood cell (RBC) transfusion in coronary artery bypass grafting (CABG) has both benefits and harms. Our aim was to study the association between perioperative RBC transfusion and its adverse outcomes in patients who underwent isolated CABG. Methods: This was a retrospective record review of patients who underwent isolated CABG in Hospital Universiti Sains Malaysia, Kelantan, Malaysia from 1 January 2013 until 31 December 2017. Data were collected from medical records, and comparisons were made between patients who received perioperative RBC transfusions and those who did not with their adverse outcomes after CABG. Results: A total of 108 patients who underwent isolated CABG were included in our study, and 78 (72.2%) patients received perioperative RBC transfusions while 30 (27.8%) patients did not. After CABG, patients who received perioperative RBC transfusions compared to those who did not, were significantly more likely to develop prolonged ventilatory support (21.8% vs. 0%, p = 0.003), cardiac morbidity (14.1% vs. 0%, p = 0.032), renal morbidity (28.2% vs. 3.3%, p = 0.005) and serious infection (20.5% vs. 3.3%, p = 0.037). With each unit of packed RBC transfusions, there was a significantly increased risk of prolonged ventilatory support (adjusted odds ratio [AOR] = 1.45; 95% confidence interval [CI] = 1.20 - 1.77; p < 0.001), cardiac morbidity (AOR = 1.40; 95% CI = 1.01 - 1.79; p = 0.007), renal morbidity (AOR = 1.23; 95% CI = 1.03 - 1.45; p = 0.019) and serious infection (AOR = 1.31; 95% CI = 1.07 - 1.60; p = 0.009). Conclusion: Perioperative RBC transfusion in isolated CABG patients is associated with increased risks of developing adverse events such as prolonged ventilatory support, cardiac morbidity, renal morbidity and serious infection 2020 Thesis http://eprints.usm.my/49358/ http://eprints.usm.my/49358/1/Chan%20Choon%20Hua-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RD Surgery
spellingShingle	RD Surgery Hua, Chan Choon Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
description	Background: Perioperative red blood cell (RBC) transfusion in coronary artery bypass grafting (CABG) has both benefits and harms. Our aim was to study the association between perioperative RBC transfusion and its adverse outcomes in patients who underwent isolated CABG. Methods: This was a retrospective record review of patients who underwent isolated CABG in Hospital Universiti Sains Malaysia, Kelantan, Malaysia from 1 January 2013 until 31 December 2017. Data were collected from medical records, and comparisons were made between patients who received perioperative RBC transfusions and those who did not with their adverse outcomes after CABG. Results: A total of 108 patients who underwent isolated CABG were included in our study, and 78 (72.2%) patients received perioperative RBC transfusions while 30 (27.8%) patients did not. After CABG, patients who received perioperative RBC transfusions compared to those who did not, were significantly more likely to develop prolonged ventilatory support (21.8% vs. 0%, p = 0.003), cardiac morbidity (14.1% vs. 0%, p = 0.032), renal morbidity (28.2% vs. 3.3%, p = 0.005) and serious infection (20.5% vs. 3.3%, p = 0.037). With each unit of packed RBC transfusions, there was a significantly increased risk of prolonged ventilatory support (adjusted odds ratio [AOR] = 1.45; 95% confidence interval [CI] = 1.20 - 1.77; p < 0.001), cardiac morbidity (AOR = 1.40; 95% CI = 1.01 - 1.79; p = 0.007), renal morbidity (AOR = 1.23; 95% CI = 1.03 - 1.45; p = 0.019) and serious infection (AOR = 1.31; 95% CI = 1.07 - 1.60; p = 0.009). Conclusion: Perioperative RBC transfusion in isolated CABG patients is associated with increased risks of developing adverse events such as prolonged ventilatory support, cardiac morbidity, renal morbidity and serious infection
format	Thesis
qualification_level	Master's degree
author	Hua, Chan Choon
author_facet	Hua, Chan Choon
author_sort	Hua, Chan Choon
title	Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_short	Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_full	Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_fullStr	Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_full_unstemmed	Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_sort	adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/49358/1/Chan%20Choon%20Hua-24%20pages.pdf
_version_	1747821993477013504

Adverse outcomes of perioperative red blood cell transfusions in coronary artery bypass grafting in Hospital Universiti Sains Malaysia

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