Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia

Chronic periodontitis is a low grade inflammatory infection of supporting periodontal structure ocurring in the presence of pathogenic flora and plaque biofilm interaction with immune system over a period of time. Multiple risk factors such as smoking, alcohol intake, stress, obesity and metaboli...

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Main Author:	Asif, Saba
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RK Dentistry
Online Access:	http://eprints.usm.my/49882/1/SABA%20ASIF-FINAL%20%20THESIS%20P-SGM000118%28R%29%20PWD_-24%20pages.pdf
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spelling	my-usm-ep.498822021-09-12T03:21:27Z Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia 2020-10 Asif, Saba RK Dentistry Chronic periodontitis is a low grade inflammatory infection of supporting periodontal structure ocurring in the presence of pathogenic flora and plaque biofilm interaction with immune system over a period of time. Multiple risk factors such as smoking, alcohol intake, stress, obesity and metabolic syndrome, diabetes mellitus, other systemic diseases or conditions have been identified as a potential risk factors for this disease. The aim for this study is to assess and evaluate the association between levels of salivary cortisol, RANKL and OPG protein biomarkers in chronic periodontitis (CP) patients. In this cross sectional study, clinical periodontal parameters [periodontal pocket depth (PPD), clinical attachment level (CAL), plaque score (PS) and gingival bleeding index (GBI)] were performed and DASS-21 scores were assessed from the survey form. Protein concentrations for salivary cortisol, RANKL and OPG were assessed in study groups consisting of mild chronic periodontitis patients in group 2, moderate to severe chronic periodontitis patients in group 3 and healthy subjects in group 1 at Periodontic Clinics of School of Dental Sciences, Hospital Universiti Sains Malaysia. Mean levels for salivary cortisol, RANKL and OPG protein were higher for group 3 (moderate to severe chronic periodontitis) with 7.46 ng/ml, 0.23 ng/ml and 1.78 ng/ml. Higher depression, anxiety and stress score were also noted for group 3 (moderate to severe chronic periodontitis) from DASS-21 questionairre. DASS scores were significantly 2020-10 Thesis http://eprints.usm.my/49882/ http://eprints.usm.my/49882/1/SABA%20ASIF-FINAL%20%20THESIS%20P-SGM000118%28R%29%20PWD_-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Pergigian
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Asif, Saba Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
description	Chronic periodontitis is a low grade inflammatory infection of supporting periodontal structure ocurring in the presence of pathogenic flora and plaque biofilm interaction with immune system over a period of time. Multiple risk factors such as smoking, alcohol intake, stress, obesity and metabolic syndrome, diabetes mellitus, other systemic diseases or conditions have been identified as a potential risk factors for this disease. The aim for this study is to assess and evaluate the association between levels of salivary cortisol, RANKL and OPG protein biomarkers in chronic periodontitis (CP) patients. In this cross sectional study, clinical periodontal parameters [periodontal pocket depth (PPD), clinical attachment level (CAL), plaque score (PS) and gingival bleeding index (GBI)] were performed and DASS-21 scores were assessed from the survey form. Protein concentrations for salivary cortisol, RANKL and OPG were assessed in study groups consisting of mild chronic periodontitis patients in group 2, moderate to severe chronic periodontitis patients in group 3 and healthy subjects in group 1 at Periodontic Clinics of School of Dental Sciences, Hospital Universiti Sains Malaysia. Mean levels for salivary cortisol, RANKL and OPG protein were higher for group 3 (moderate to severe chronic periodontitis) with 7.46 ng/ml, 0.23 ng/ml and 1.78 ng/ml. Higher depression, anxiety and stress score were also noted for group 3 (moderate to severe chronic periodontitis) from DASS-21 questionairre. DASS scores were significantly
format	Thesis
qualification_level	Master's degree
author	Asif, Saba
author_facet	Asif, Saba
author_sort	Asif, Saba
title	Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
title_short	Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
title_full	Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
title_fullStr	Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
title_full_unstemmed	Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia
title_sort	evaluation of salivary cortisol, rankl and opg levels in chronic periodontitis patients attending hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Pergigian
publishDate	2020
url	http://eprints.usm.my/49882/1/SABA%20ASIF-FINAL%20%20THESIS%20P-SGM000118%28R%29%20PWD_-24%20pages.pdf
_version_	1747822020201021440

Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia

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