Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective

Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of part...

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Main Author:	Mahmud, Mohamad Nizam
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf
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id	my-usm-ep.50235
record_format	uketd_dc
spelling	my-usm-ep.502352021-10-13T01:32:59Z Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective 2020 Mahmud, Mohamad Nizam R Medicine Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of participants in both the INS and control groups comprising of children without chronic illness were asked to complete questionnaires using the Child Behavioural Checklist (CBCL). CBCL measures a range of age-specific emotional and psychological problems, including Internalising and Externalising domains. Analyses of the CBCL scores between the groups were performed using the Mann–Whitney test. Results: A total of 140 children were recruited with equal numbers in the INS and control groups. There was a significant difference in the mean total CBCL scores between the INS and control groups, specifically in the withdrawal, somatic, anxious and aggressiveness sub-domains. Similar findings were demonstrated in the correlation between total psychological problems and corticosteroid dosage. In the INS group, steroid dose and cushingoid features were found to have a significant positive association with internalising psychological problems. Likewise, steroid dose and age were significantly associated with externalising scores. Conclusion: Children with INS on corticosteroid therapy showed an increase in internalising and externalising scores compared to healthy children. 2020 Thesis http://eprints.usm.my/50235/ http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Mahmud, Mohamad Nizam Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
description	Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of participants in both the INS and control groups comprising of children without chronic illness were asked to complete questionnaires using the Child Behavioural Checklist (CBCL). CBCL measures a range of age-specific emotional and psychological problems, including Internalising and Externalising domains. Analyses of the CBCL scores between the groups were performed using the Mann–Whitney test. Results: A total of 140 children were recruited with equal numbers in the INS and control groups. There was a significant difference in the mean total CBCL scores between the INS and control groups, specifically in the withdrawal, somatic, anxious and aggressiveness sub-domains. Similar findings were demonstrated in the correlation between total psychological problems and corticosteroid dosage. In the INS group, steroid dose and cushingoid features were found to have a significant positive association with internalising psychological problems. Likewise, steroid dose and age were significantly associated with externalising scores. Conclusion: Children with INS on corticosteroid therapy showed an increase in internalising and externalising scores compared to healthy children.
format	Thesis
qualification_level	Master's degree
author	Mahmud, Mohamad Nizam
author_facet	Mahmud, Mohamad Nizam
author_sort	Mahmud, Mohamad Nizam
title	Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_short	Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_full	Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_fullStr	Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_full_unstemmed	Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_sort	increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a south est asian perspective
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf
_version_	1747822029024788480

Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective

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