Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months

Background and Objective Cognitive impairment (CI) and neuropsychiatry manifestation (NM) are known complications among patients with traumatic brain injury (TBI). However, the clinical correlation of mild and moderate TBI with CI and NM have not been extensively studied in Malaysia. Our objecti...

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Main Author:	Othman, Muhammad Aizzat
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50236/1/MUHAMMAD%20AIZZAT%20B.%20OTHMAN-24%20pages.pdf
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spelling	my-usm-ep.502362021-10-13T01:46:57Z Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months 2020 Othman, Muhammad Aizzat R Medicine Background and Objective Cognitive impairment (CI) and neuropsychiatry manifestation (NM) are known complications among patients with traumatic brain injury (TBI). However, the clinical correlation of mild and moderate TBI with CI and NM have not been extensively studied in Malaysia. Our objectives were to determine i) the prevalence of CI and NM in mild and moderate TBI, ii) association between mild and moderate TBI with CI and NM and iii) association between risk factors with CI and NM. Methods Patients (n=54) were divided into mild and moderate TBI. Both mild (n=26) and moderate (n=28) TBI were assessed at 3 months and 6 months post trauma for the same measures. Diagnosis of CI was made by using The Montreal Cognitive Assessment (MoCA) while NM screening was done using General Health Questionnaire-12 (GHQ-12) followed by MINI International Neuropsychiatry Interview (MINI) for diagnostic purpose. Univariate analyses were done using chi square tests and multivariate analysis with multiple logistic regression test. Results We found 5 patients (19.2%) with mild TBI had CI and 5 patients (19.2%) had NM at 3 months. Only 1 patient (3.8%) persistently has CI at 6 months while the rest recovered. As for moderate TBI, 11 patients (39.3%) had CI and 7 patients (25%) had NM at 3 months but none had persistent CI or NM at 6 months. Age Umur (p<0.05, OR 0.678, CI 0.463 – 0.995) and blood pressure were significant risks ((p< 0.05, OR 1.223, CI: 1.001 – 1.495) for CI and NM at 3 months. Conclusion This study highlighted the importance of screening for both CI and NM following mild and moderate TBI at 3 months and 6 months. These data are essential to help treating clinicians identifying potential risk factors among post head trauma patients. Therefore, early recognition facilitates effective rehabilitation programs planning hence improve prognosis in the future. 2020 Thesis http://eprints.usm.my/50236/ http://eprints.usm.my/50236/1/MUHAMMAD%20AIZZAT%20B.%20OTHMAN-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Othman, Muhammad Aizzat Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
description	Background and Objective Cognitive impairment (CI) and neuropsychiatry manifestation (NM) are known complications among patients with traumatic brain injury (TBI). However, the clinical correlation of mild and moderate TBI with CI and NM have not been extensively studied in Malaysia. Our objectives were to determine i) the prevalence of CI and NM in mild and moderate TBI, ii) association between mild and moderate TBI with CI and NM and iii) association between risk factors with CI and NM. Methods Patients (n=54) were divided into mild and moderate TBI. Both mild (n=26) and moderate (n=28) TBI were assessed at 3 months and 6 months post trauma for the same measures. Diagnosis of CI was made by using The Montreal Cognitive Assessment (MoCA) while NM screening was done using General Health Questionnaire-12 (GHQ-12) followed by MINI International Neuropsychiatry Interview (MINI) for diagnostic purpose. Univariate analyses were done using chi square tests and multivariate analysis with multiple logistic regression test. Results We found 5 patients (19.2%) with mild TBI had CI and 5 patients (19.2%) had NM at 3 months. Only 1 patient (3.8%) persistently has CI at 6 months while the rest recovered. As for moderate TBI, 11 patients (39.3%) had CI and 7 patients (25%) had NM at 3 months but none had persistent CI or NM at 6 months. Age Umur (p<0.05, OR 0.678, CI 0.463 – 0.995) and blood pressure were significant risks ((p< 0.05, OR 1.223, CI: 1.001 – 1.495) for CI and NM at 3 months. Conclusion This study highlighted the importance of screening for both CI and NM following mild and moderate TBI at 3 months and 6 months. These data are essential to help treating clinicians identifying potential risk factors among post head trauma patients. Therefore, early recognition facilitates effective rehabilitation programs planning hence improve prognosis in the future.
format	Thesis
qualification_level	Master's degree
author	Othman, Muhammad Aizzat
author_facet	Othman, Muhammad Aizzat
author_sort	Othman, Muhammad Aizzat
title	Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
title_short	Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
title_full	Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
title_fullStr	Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
title_full_unstemmed	Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
title_sort	cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50236/1/MUHAMMAD%20AIZZAT%20B.%20OTHMAN-24%20pages.pdf
_version_	1747822029264912384

Cognitive impairment and neuropsychiatry manifestation following mild and moderate traumatic brain injury at 3 month and 6 months

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