Keloid : multicentre study on the outcome of multimodality management

Introduction: Keloids are benign hyperproliferative growths of dermal fibroblasts characterized by the excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, proteoglycans, and growth factors such as TGF-β. They remain difficult to improve despite a pleth...

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Main Author:	Chong, Nicholas Franklin Tow Mun
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50312/1/Nicholas%20Franklin-24%20pages.pdf
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id	my-usm-ep.50312
record_format	uketd_dc
spelling	my-usm-ep.503122021-10-20T03:15:31Z Keloid : multicentre study on the outcome of multimodality management 2020 Chong, Nicholas Franklin Tow Mun R Medicine Introduction: Keloids are benign hyperproliferative growths of dermal fibroblasts characterized by the excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, proteoglycans, and growth factors such as TGF-β. They remain difficult to improve despite a plethora of advocated treatment strategies frequently observed in daily clinical routine. Hence, multimodality treatment is often recommended for optimum control of the disease. This study aims to assess the outcome of intralesional triamcinolone acetonide (TAC) injections with concurrent scar massage in management of keloid scarring in our setting, in order to optimise its management in the local population. Methods:This is a prospective observational study conducted in the Reconstructive Sciences Unit, Hospital UniversitiSains Malaysia (Hospital USM) and the Department of Plastic & Reconstructive Surgery, Hospital Kuala Lumpur (HKL). This study involves the collection of POSAS scores from patients with keloid scars while they undergo treatment with intralesional TAC injections with concurrent scar massage.The POSAS scores is used to analyse the treatment outcome of keloid scars in the Malaysian population. 2020 Thesis http://eprints.usm.my/50312/ http://eprints.usm.my/50312/1/Nicholas%20Franklin-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Chong, Nicholas Franklin Tow Mun Keloid : multicentre study on the outcome of multimodality management
description	Introduction: Keloids are benign hyperproliferative growths of dermal fibroblasts characterized by the excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, proteoglycans, and growth factors such as TGF-β. They remain difficult to improve despite a plethora of advocated treatment strategies frequently observed in daily clinical routine. Hence, multimodality treatment is often recommended for optimum control of the disease. This study aims to assess the outcome of intralesional triamcinolone acetonide (TAC) injections with concurrent scar massage in management of keloid scarring in our setting, in order to optimise its management in the local population. Methods:This is a prospective observational study conducted in the Reconstructive Sciences Unit, Hospital UniversitiSains Malaysia (Hospital USM) and the Department of Plastic & Reconstructive Surgery, Hospital Kuala Lumpur (HKL). This study involves the collection of POSAS scores from patients with keloid scars while they undergo treatment with intralesional TAC injections with concurrent scar massage.The POSAS scores is used to analyse the treatment outcome of keloid scars in the Malaysian population.
format	Thesis
qualification_level	Master's degree
author	Chong, Nicholas Franklin Tow Mun
author_facet	Chong, Nicholas Franklin Tow Mun
author_sort	Chong, Nicholas Franklin Tow Mun
title	Keloid : multicentre study on the outcome of multimodality management
title_short	Keloid : multicentre study on the outcome of multimodality management
title_full	Keloid : multicentre study on the outcome of multimodality management
title_fullStr	Keloid : multicentre study on the outcome of multimodality management
title_full_unstemmed	Keloid : multicentre study on the outcome of multimodality management
title_sort	keloid : multicentre study on the outcome of multimodality management
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50312/1/Nicholas%20Franklin-24%20pages.pdf
_version_	1747822032698998784

Keloid : multicentre study on the outcome of multimodality management

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