Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study

Aim: To determine factors associated with uncomplicated prolonged neonatal jaundice in Malay term infants. Methods: A case-control study was conducted in 120 prolonged neonatal jaundice infants and 120 healthy control infants, in a pediatric clinic of a tertiary center between February 2018 and Sep...

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Main Author:	Zahedi, Nor Amirah Ahmad
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50402/1/Nor%20Amirah%20Mohd%20Zahedi-24%20pages.pdf
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id	my-usm-ep.50402
record_format	uketd_dc
spelling	my-usm-ep.504022021-10-27T01:18:35Z Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study 2020 Zahedi, Nor Amirah Ahmad R Medicine Aim: To determine factors associated with uncomplicated prolonged neonatal jaundice in Malay term infants. Methods: A case-control study was conducted in 120 prolonged neonatal jaundice infants and 120 healthy control infants, in a pediatric clinic of a tertiary center between February 2018 and September 2018. Cases were selected from specialized prolonged jaundice clinic while, controls were healthy infants conveniently selected from neonatal clinic. Data was gathered from caretaker interviews, home-based vaccination records, and attending physician records. Regression analysis was performed to determine the independent associated factors of prolonged unconjugated jaundice. Results: Hundred and twenty infants with prolonged unconjugated jaundice was analyzed in this study, of which 44.2% jaundice had resolved upon reviewed at 31 days of life. Cases and control age between 2 weeks to 8 weeks. Univariate analysis demonstrated potentialassociations observed in maternal history of gestational diabetes mellitus, maternal intrapartum usage of oxytocin,vaginal versus caesarian delivery,SGA versus AGA birth weight babies, G6PD deficiency,congenital hypothyroidism, and exclusive breastfeeding versus mixed feeding. G6PD deficiency was a predicted risk factor(adjusted OR 5.3 CI 1.02-28.20) for prolonged jaundice with unexpected negative association of congenital hypothyroidism(adjusted OR 0.057 95% CI 0.01-0.72), infant of maternal gestational diabetes mellitus(adjusted OR 0.31 95% CI 0.15-0.65), and SGA birth weight (adjusted OR 0.20 95% CI 0.10-0.396). Conclusion: This study demonstrates positive relationship between G6PD deficiency and prolonged unconjugated jaundice. However, maternal history gestational diabetes mellitus, congenital hypothyroidism and SGA birth weight were protective factors for prolonged unconjugated jaundice in our population. 2020 Thesis http://eprints.usm.my/50402/ http://eprints.usm.my/50402/1/Nor%20Amirah%20Mohd%20Zahedi-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Zahedi, Nor Amirah Ahmad Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
description	Aim: To determine factors associated with uncomplicated prolonged neonatal jaundice in Malay term infants. Methods: A case-control study was conducted in 120 prolonged neonatal jaundice infants and 120 healthy control infants, in a pediatric clinic of a tertiary center between February 2018 and September 2018. Cases were selected from specialized prolonged jaundice clinic while, controls were healthy infants conveniently selected from neonatal clinic. Data was gathered from caretaker interviews, home-based vaccination records, and attending physician records. Regression analysis was performed to determine the independent associated factors of prolonged unconjugated jaundice. Results: Hundred and twenty infants with prolonged unconjugated jaundice was analyzed in this study, of which 44.2% jaundice had resolved upon reviewed at 31 days of life. Cases and control age between 2 weeks to 8 weeks. Univariate analysis demonstrated potentialassociations observed in maternal history of gestational diabetes mellitus, maternal intrapartum usage of oxytocin,vaginal versus caesarian delivery,SGA versus AGA birth weight babies, G6PD deficiency,congenital hypothyroidism, and exclusive breastfeeding versus mixed feeding. G6PD deficiency was a predicted risk factor(adjusted OR 5.3 CI 1.02-28.20) for prolonged jaundice with unexpected negative association of congenital hypothyroidism(adjusted OR 0.057 95% CI 0.01-0.72), infant of maternal gestational diabetes mellitus(adjusted OR 0.31 95% CI 0.15-0.65), and SGA birth weight (adjusted OR 0.20 95% CI 0.10-0.396). Conclusion: This study demonstrates positive relationship between G6PD deficiency and prolonged unconjugated jaundice. However, maternal history gestational diabetes mellitus, congenital hypothyroidism and SGA birth weight were protective factors for prolonged unconjugated jaundice in our population.
format	Thesis
qualification_level	Master's degree
author	Zahedi, Nor Amirah Ahmad
author_facet	Zahedi, Nor Amirah Ahmad
author_sort	Zahedi, Nor Amirah Ahmad
title	Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
title_short	Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
title_full	Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
title_fullStr	Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
title_full_unstemmed	Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study
title_sort	factors associated with uncomplicated prolonged neonatal jaundice in term malay infants : a case control study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50402/1/Nor%20Amirah%20Mohd%20Zahedi-24%20pages.pdf
_version_	1747822035646545920

Factors associated with uncomplicated prolonged neonatal jaundice in term Malay infants : a case control study

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