Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure

Introduction: Healing of diabetic foot ulcer is often a challenging problem due to lack of resistance against infection and presence of peripheral arterial disease in diabetic patients. The use of negative pressure wound therapy (NPWT) to facilitate the healing of diabetic foot ulcer had been stu...

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Main Author:	Zarullail, Nor Hafizah
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50524/1/NOR%20HAFIZAH%20BINTI%20ZARULLAIL-24%20pages.pdf
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spelling	my-usm-ep.505242021-11-07T05:50:17Z Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure 2020 Zarullail, Nor Hafizah R Medicine Introduction: Healing of diabetic foot ulcer is often a challenging problem due to lack of resistance against infection and presence of peripheral arterial disease in diabetic patients. The use of negative pressure wound therapy (NPWT) to facilitate the healing of diabetic foot ulcer had been studied by many people. To date, the optimal pressure for NPWT was -125mmHg. The aim of this study is to compare the effectiveness of low pressure (-50 mmHg) and high pressure (-100 mmHg) NPWT in term of wound size reduction and optimal wound bed preparation for secondary procedure. Methodology: This was a prospective interventional, randomized controlled trial study done on patients with diabetic foot ulcer admitted to orthopaedic ward, Hospital Universiti Sains Malaysia. A total of 58 patients which were randomly assigned into 2 groups either low pressure (-50 mmHg) or high pressure (-100 mmHg) NPWT and the outcome measured were wound size reduction and wound bed score. Patients demographic data were collected and statistical analysis was done using repeated measure analysis of variance (ANOVA) to determine the relationship between the treatment and outcomes measured. Result: Both treatment groups show significance changes in term of wound size reduction and wound bed score. However there is no significance difference when comparing in between both treatment group with measured outcomes. Discussion/Conclusion: Negative pressure wound therapy facilitate the healing of diabetic foot ulcer by reducing the wound size and expediates wound bed preparation for secondary procedure even though there were no significance difference in between the level of negative pressure used. The level of negative pressure used should be tailored to individual patient and the aim of treatment. 2020 Thesis http://eprints.usm.my/50524/ http://eprints.usm.my/50524/1/NOR%20HAFIZAH%20BINTI%20ZARULLAIL-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Zarullail, Nor Hafizah Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
description	Introduction: Healing of diabetic foot ulcer is often a challenging problem due to lack of resistance against infection and presence of peripheral arterial disease in diabetic patients. The use of negative pressure wound therapy (NPWT) to facilitate the healing of diabetic foot ulcer had been studied by many people. To date, the optimal pressure for NPWT was -125mmHg. The aim of this study is to compare the effectiveness of low pressure (-50 mmHg) and high pressure (-100 mmHg) NPWT in term of wound size reduction and optimal wound bed preparation for secondary procedure. Methodology: This was a prospective interventional, randomized controlled trial study done on patients with diabetic foot ulcer admitted to orthopaedic ward, Hospital Universiti Sains Malaysia. A total of 58 patients which were randomly assigned into 2 groups either low pressure (-50 mmHg) or high pressure (-100 mmHg) NPWT and the outcome measured were wound size reduction and wound bed score. Patients demographic data were collected and statistical analysis was done using repeated measure analysis of variance (ANOVA) to determine the relationship between the treatment and outcomes measured. Result: Both treatment groups show significance changes in term of wound size reduction and wound bed score. However there is no significance difference when comparing in between both treatment group with measured outcomes. Discussion/Conclusion: Negative pressure wound therapy facilitate the healing of diabetic foot ulcer by reducing the wound size and expediates wound bed preparation for secondary procedure even though there were no significance difference in between the level of negative pressure used. The level of negative pressure used should be tailored to individual patient and the aim of treatment.
format	Thesis
qualification_level	Master's degree
author	Zarullail, Nor Hafizah
author_facet	Zarullail, Nor Hafizah
author_sort	Zarullail, Nor Hafizah
title	Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
title_short	Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
title_full	Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
title_fullStr	Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
title_full_unstemmed	Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
title_sort	comparison between low and high pressure negative pressure wound therapy (npwt) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50524/1/NOR%20HAFIZAH%20BINTI%20ZARULLAIL-24%20pages.pdf
_version_	1747822040325292032

Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure

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