The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian

Background: Hydration status assessment is important in management of patient with hyponatremia. There is no previous study that shows association between patients’s clinical and biochemical assessment with hydration status in hospitalized patients with hyponatremia. Objective of this study was to l...

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Main Author:	Doroh, Nuraina Syazreena Ab
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/50996/1/NURAINA%20SYAZREENA%20BINTI%20AB%20DOROH-24%20pages.pdf
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spelling	my-usm-ep.509962021-12-29T03:39:37Z The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian 2020 Doroh, Nuraina Syazreena Ab R Medicine Background: Hydration status assessment is important in management of patient with hyponatremia. There is no previous study that shows association between patients’s clinical and biochemical assessment with hydration status in hospitalized patients with hyponatremia. Objective of this study was to look at the association between clinical and biochemical parameters in patient and hypovolemic hyponatremia. Methods: This cross-sectional study was conducted in June 2020 till August 2020 involving patients with hyponatremia, hospitalized in Hospital Universiti Sains Malaysia. A total of 87 patients with hyponatremia were selected. All patients’ information such as age, comorbidities, drug history particularly diuretics, diagnosis during admission, weight, height, body mass index, clinical assessment including systolic and diastolic blood pressure , heart rate and sternal skin turgor as well as biochemical parameters such as serum sodium, serum urea, serum uric acid, serum and urine osmolarity, urine sodium were obtained, followed by assessment of hydration status using Biolectrical Impedance Analysis Machine (Bodystat Quadscan). Results of hydration status will be divided into hypovolemic and non-hypovolemic group based on total body water analysis. Univariable and multivariable analysis by logistic regression were conducted to identify association of this clinical and biochemical parameters with hypovolemic hyponatremia. Results: Among 87 patients with hyponatremia, 35 (40.2%) of them had hypovolemia and 52 (59.8%) had non-hypovolemia. Hypovolemic group consists of 23 (65.7%) female and 12 (34.3%) male. The mean (SD) serum Na for hypovolemic group and non-hypovolemic group were 126.9 (±4.27) and 127 (±4.52) respectively. In hypovolemic group, 5 (14.3%) had underlying malignancy and 14 (40%) had underlying DM. Mean BMI for hypovolemic group was 23.6 (±4.24) and 22.7 (±2.84) for non-hypovolemic hyponatremia group. Significant association of low systolic BP and high serum urea with hypovolemic hyponatremia have been found (adj OR 0.92, 95% CI 0.873, 0.969, p=0.002; adj OR 1.27, 95% CI 1.12, 1.43, p <0.001) Conclusion: Low systolic BP and high serum urea are significantly associated with hypovolemic hyponatremia among hospitalized patients with hyponatremia. Hence, assessment of systolic BP and measurement of serum urea can helps in predicting hospitalized patient with hypovolemic hyponatremia and to guide for further workout to look for the possible etiology and endorsing subsequent management 2020 Thesis http://eprints.usm.my/50996/ http://eprints.usm.my/50996/1/NURAINA%20SYAZREENA%20BINTI%20AB%20DOROH-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Doroh, Nuraina Syazreena Ab The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
description	Background: Hydration status assessment is important in management of patient with hyponatremia. There is no previous study that shows association between patients’s clinical and biochemical assessment with hydration status in hospitalized patients with hyponatremia. Objective of this study was to look at the association between clinical and biochemical parameters in patient and hypovolemic hyponatremia. Methods: This cross-sectional study was conducted in June 2020 till August 2020 involving patients with hyponatremia, hospitalized in Hospital Universiti Sains Malaysia. A total of 87 patients with hyponatremia were selected. All patients’ information such as age, comorbidities, drug history particularly diuretics, diagnosis during admission, weight, height, body mass index, clinical assessment including systolic and diastolic blood pressure , heart rate and sternal skin turgor as well as biochemical parameters such as serum sodium, serum urea, serum uric acid, serum and urine osmolarity, urine sodium were obtained, followed by assessment of hydration status using Biolectrical Impedance Analysis Machine (Bodystat Quadscan). Results of hydration status will be divided into hypovolemic and non-hypovolemic group based on total body water analysis. Univariable and multivariable analysis by logistic regression were conducted to identify association of this clinical and biochemical parameters with hypovolemic hyponatremia. Results: Among 87 patients with hyponatremia, 35 (40.2%) of them had hypovolemia and 52 (59.8%) had non-hypovolemia. Hypovolemic group consists of 23 (65.7%) female and 12 (34.3%) male. The mean (SD) serum Na for hypovolemic group and non-hypovolemic group were 126.9 (±4.27) and 127 (±4.52) respectively. In hypovolemic group, 5 (14.3%) had underlying malignancy and 14 (40%) had underlying DM. Mean BMI for hypovolemic group was 23.6 (±4.24) and 22.7 (±2.84) for non-hypovolemic hyponatremia group. Significant association of low systolic BP and high serum urea with hypovolemic hyponatremia have been found (adj OR 0.92, 95% CI 0.873, 0.969, p=0.002; adj OR 1.27, 95% CI 1.12, 1.43, p <0.001) Conclusion: Low systolic BP and high serum urea are significantly associated with hypovolemic hyponatremia among hospitalized patients with hyponatremia. Hence, assessment of systolic BP and measurement of serum urea can helps in predicting hospitalized patient with hypovolemic hyponatremia and to guide for further workout to look for the possible etiology and endorsing subsequent management
format	Thesis
qualification_level	Master's degree
author	Doroh, Nuraina Syazreena Ab
author_facet	Doroh, Nuraina Syazreena Ab
author_sort	Doroh, Nuraina Syazreena Ab
title	The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
title_short	The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
title_full	The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
title_fullStr	The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
title_full_unstemmed	The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian
title_sort	study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in hospital usm kubang kerian
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/50996/1/NURAINA%20SYAZREENA%20BINTI%20AB%20DOROH-24%20pages.pdf
_version_	1747822050580365312

The study of clinical and biochemical factors associated with hypovolemia among hospitalised patients with hyponatremia based on bioimpedence analysis in Hospital USM Kubang Kerian

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