Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin

Carbonate apatite (CO3Ap) has been received much attention in bone grafting due to similar chemical composition to human bone. However, CO3Ap artificial bone substitute still has not been commercialized due to the low thermal stability of carbonate at high temperature. Besides that, common limitatio...

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Main Author:	Darus, Fadilah Mohd
Format:	Thesis
Language:	English
Published:	2019
Subjects:	T Technology
Online Access:	http://eprints.usm.my/51459/1/Fabrication%20And%20Characterization%20Of%20Carbonate%20Apatite%20Scaffolds%20Coated%20With%20Alginate%20And%20Gelatin.pdf
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spelling	my-usm-ep.514592022-02-08T08:17:29Z Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin 2019-04-01 Darus, Fadilah Mohd T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Carbonate apatite (CO3Ap) has been received much attention in bone grafting due to similar chemical composition to human bone. However, CO3Ap artificial bone substitute still has not been commercialized due to the low thermal stability of carbonate at high temperature. Besides that, common limitation of porous materials, which is lack of strength should be taken into consideration. The aim of the present study is to fabricate CO3Ap scaffold using dissolution-precipitation reaction during hydrothermal treatment and to improve the compressive strength of scaffold by using natural polymer coating. Effect of two different solutions, which is NaHCO3 and Na2CO3 on β-TCP scaffold prepared via dissolution-precipitation reaction was investigated. It is found that CO3Ap scaffold with 8.95 wt.% carbonate content were successfully fabricated by NaHCO3 solution. The average pore size of the scaffold is approximately 180 μm with 72% porosity. The average compressive strength obtained of CO3Ap scaffold was 0.7 MPa. Coating of CO3Ap scaffold with alginate and gelatin was performed. Compressive strength was increased up to 1.31 MPa and 1.08 MPa, which represent 34% and 46% increment, respectively. In order to make chemical link between CO3Ap scaffold and coating, silane coupling agent A174 was used. Compressive strength of the 5SA-CO3Ap and 5BG-CO3Ap scaffold after treated with silane improved by 40% and 35%, respectively. In conclusion, treated 5SA-CO3Ap shows the highest strength with 2.17 MPa and 52% in porosity is sufficient for application of cancellous bone repair where the lowest bound for human cancellous bone is > 0.15 MPa and 50 – 90 % in porosity. 2019-04 Thesis http://eprints.usm.my/51459/ http://eprints.usm.my/51459/1/Fabrication%20And%20Characterization%20Of%20Carbonate%20Apatite%20Scaffolds%20Coated%20With%20Alginate%20And%20Gelatin.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Darus, Fadilah Mohd Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
description	Carbonate apatite (CO3Ap) has been received much attention in bone grafting due to similar chemical composition to human bone. However, CO3Ap artificial bone substitute still has not been commercialized due to the low thermal stability of carbonate at high temperature. Besides that, common limitation of porous materials, which is lack of strength should be taken into consideration. The aim of the present study is to fabricate CO3Ap scaffold using dissolution-precipitation reaction during hydrothermal treatment and to improve the compressive strength of scaffold by using natural polymer coating. Effect of two different solutions, which is NaHCO3 and Na2CO3 on β-TCP scaffold prepared via dissolution-precipitation reaction was investigated. It is found that CO3Ap scaffold with 8.95 wt.% carbonate content were successfully fabricated by NaHCO3 solution. The average pore size of the scaffold is approximately 180 μm with 72% porosity. The average compressive strength obtained of CO3Ap scaffold was 0.7 MPa. Coating of CO3Ap scaffold with alginate and gelatin was performed. Compressive strength was increased up to 1.31 MPa and 1.08 MPa, which represent 34% and 46% increment, respectively. In order to make chemical link between CO3Ap scaffold and coating, silane coupling agent A174 was used. Compressive strength of the 5SA-CO3Ap and 5BG-CO3Ap scaffold after treated with silane improved by 40% and 35%, respectively. In conclusion, treated 5SA-CO3Ap shows the highest strength with 2.17 MPa and 52% in porosity is sufficient for application of cancellous bone repair where the lowest bound for human cancellous bone is > 0.15 MPa and 50 – 90 % in porosity.
format	Thesis
qualification_level	Master's degree
author	Darus, Fadilah Mohd
author_facet	Darus, Fadilah Mohd
author_sort	Darus, Fadilah Mohd
title	Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
title_short	Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
title_full	Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
title_fullStr	Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
title_full_unstemmed	Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin
title_sort	fabrication and characterization of carbonate apatite scaffolds coated with alginate and gelatin
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan Sumber Mineral
publishDate	2019
url	http://eprints.usm.my/51459/1/Fabrication%20And%20Characterization%20Of%20Carbonate%20Apatite%20Scaffolds%20Coated%20With%20Alginate%20And%20Gelatin.pdf
_version_	1747822071170203648

Fabrication And Characterization Of Carbonate Apatite Scaffolds Coated With Alginate And Gelatin

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