Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials

Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials

In this research, four senes of a total of 33 compounds consisting of chalcone, pyrazoline, phthalimide ester and xanthone heterocyclic analogues were synthesized and were crystallized. Their molecular structures were elucidated by Xray diffraction method, using either Bruker SMART APEX II or Bruker...

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Main Author: Loh, Wan Sin
Format: Thesis
Published: 2016
Subjects:
QC1 Physics (General)
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spelling my-usm-ep.515812022-02-18T15:31:19Z Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials 2016-07 Loh, Wan Sin QC1 Physics (General) In this research, four senes of a total of 33 compounds consisting of chalcone, pyrazoline, phthalimide ester and xanthone heterocyclic analogues were synthesized and were crystallized. Their molecular structures were elucidated by Xray diffraction method, using either Bruker SMART APEX II or Bruker APEX II DUO CCD area-detector diffractometers. It revealed the importance ofsubstituents on the crystal stability and molecular packing. Subsequently, they were screened for their biological potentials such as antioxidants, antimicrobial and anticancer. Chalcone derivatives showed mild to good antioxidant ability. Among them derivatives with methoxy substituents (-OCH3) at their phenyl rings exhibited the highest antioxidant activity. Chalcone with halogen sub tituents were te ted for antimicrobial activity and were found that fluoro substituent at -para po ition of the phenyl ring showed elevated antimicrobial activity. Pyrazoline derivatives displayed insignificant activity towards antioxidant and antimicrobial activitie . Phthalimide ester derivatives were evaluated for their in-vitro antioxidant properties 2016-07 Thesis http://eprints.usm.my/51581/ phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution Universiti Sains Malaysia
collection USM Institutional Repository
topic QC1 Physics (General)
spellingShingle QC1 Physics (General)
Loh, Wan Sin
Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
description In this research, four senes of a total of 33 compounds consisting of chalcone, pyrazoline, phthalimide ester and xanthone heterocyclic analogues were synthesized and were crystallized. Their molecular structures were elucidated by Xray diffraction method, using either Bruker SMART APEX II or Bruker APEX II DUO CCD area-detector diffractometers. It revealed the importance ofsubstituents on the crystal stability and molecular packing. Subsequently, they were screened for their biological potentials such as antioxidants, antimicrobial and anticancer. Chalcone derivatives showed mild to good antioxidant ability. Among them derivatives with methoxy substituents (-OCH3) at their phenyl rings exhibited the highest antioxidant activity. Chalcone with halogen sub tituents were te ted for antimicrobial activity and were found that fluoro substituent at -para po ition of the phenyl ring showed elevated antimicrobial activity. Pyrazoline derivatives displayed insignificant activity towards antioxidant and antimicrobial activitie . Phthalimide ester derivatives were evaluated for their in-vitro antioxidant properties
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Loh, Wan Sin
author_facet Loh, Wan Sin
author_sort Loh, Wan Sin
title Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
title_short Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
title_full Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
title_fullStr Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
title_full_unstemmed Structural analysis of some heterocyclic analogues (Chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
title_sort structural analysis of some heterocyclic analogues (chalcone, pyrazoline, ester and xanthone) and evaluation of their biological potentials
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Fizik
publishDate 2016
_version_ 1747822081432616960

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