A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia

To compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency. Methodology This is an open labeled randomized prospective control study with blinded end point conducted from Oct 2006-Sept 2007. Patient aged> 18-year-old with persistent elevated BP> 180/110...

Full description

Saved in:

Bibliographic Details
Main Author:	Chia Boon, Yang
Format:	Thesis
Language:	English
Published:	2008
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/51594/1/DR.%20CHIA%20BOON%20YANG%20-%2024%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.51594
record_format	uketd_dc
spelling	my-usm-ep.515942022-02-22T01:48:54Z A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia 2008 Chia Boon, Yang R Medicine (General) To compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency. Methodology This is an open labeled randomized prospective control study with blinded end point conducted from Oct 2006-Sept 2007. Patient aged> 18-year-old with persistent elevated BP> 180/110 mmHg after 30 min bed rest was included in the study. Patient who allergic to study drugs, with target organ damage (acute coronary syndrome, CVA, CRF), elevated blood sugar >20mmolll, pregnancy or breast feeding was excluded. Patients were randomized using block randomization into amlodipine group (Amlodipine 5 mg) and captopril group (Captopril 25 mg). Single NIBP machine was used to monitor BP and PR hourly for 4 hours, subsequently 4 hourly until 16th hour of medication. If target BP not achieved at 4th hour of medication, Chlorothiazide 250 mg was added. Result 28 patients enrolled in the study, 18 patients in amlodipine group and 10 patients in captopril group. Mean age for amlodipine group was 60.2 years old (sd 13.02) and 45.0 years old (sd 14.73) for captopril group, p=0.046. Mean SBP on admission was 206.9 xiii mmHg (sd 27.16) for amlodipine group compared to 198.4 mmHg (sd 14.32) for captopril group, p=0.487. SBP at 1st hour was significantly difference with p=0.004. The SBP reduced gradually from 2nd to 161h hour, with no significant difference. DBP on admission was significantly difference (p=0.009) with mean at 112.4 mmHg (sd 9.47) in amlodipine group and 124.2 nunHg (sd 1 0.17) in captopril group. However, the differences in DBP were not significant throughout the study. The mean MAP on admission was 143.9 nunHg (sd 9.27) in amlodipine group compared to 148.9 mmHg (sd 7.75) in captopril group, p=O.l37. The differences in MAP and PR between study groups were not significant. Conclusion Amlodipine is comparable to captopril in the treatment of hypertension urgency. Keywords Hypertensive urgency; Emergency department; Amlodipine; Captopril 2008 Thesis http://eprints.usm.my/51594/ http://eprints.usm.my/51594/1/DR.%20CHIA%20BOON%20YANG%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Chia Boon, Yang A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
description	To compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency. Methodology This is an open labeled randomized prospective control study with blinded end point conducted from Oct 2006-Sept 2007. Patient aged> 18-year-old with persistent elevated BP> 180/110 mmHg after 30 min bed rest was included in the study. Patient who allergic to study drugs, with target organ damage (acute coronary syndrome, CVA, CRF), elevated blood sugar >20mmolll, pregnancy or breast feeding was excluded. Patients were randomized using block randomization into amlodipine group (Amlodipine 5 mg) and captopril group (Captopril 25 mg). Single NIBP machine was used to monitor BP and PR hourly for 4 hours, subsequently 4 hourly until 16th hour of medication. If target BP not achieved at 4th hour of medication, Chlorothiazide 250 mg was added. Result 28 patients enrolled in the study, 18 patients in amlodipine group and 10 patients in captopril group. Mean age for amlodipine group was 60.2 years old (sd 13.02) and 45.0 years old (sd 14.73) for captopril group, p=0.046. Mean SBP on admission was 206.9 xiii mmHg (sd 27.16) for amlodipine group compared to 198.4 mmHg (sd 14.32) for captopril group, p=0.487. SBP at 1st hour was significantly difference with p=0.004. The SBP reduced gradually from 2nd to 161h hour, with no significant difference. DBP on admission was significantly difference (p=0.009) with mean at 112.4 mmHg (sd 9.47) in amlodipine group and 124.2 nunHg (sd 1 0.17) in captopril group. However, the differences in DBP were not significant throughout the study. The mean MAP on admission was 143.9 nunHg (sd 9.27) in amlodipine group compared to 148.9 mmHg (sd 7.75) in captopril group, p=O.l37. The differences in MAP and PR between study groups were not significant. Conclusion Amlodipine is comparable to captopril in the treatment of hypertension urgency. Keywords Hypertensive urgency; Emergency department; Amlodipine; Captopril
format	Thesis
qualification_level	Master's degree
author	Chia Boon, Yang
author_facet	Chia Boon, Yang
author_sort	Chia Boon, Yang
title	A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
title_short	A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
title_full	A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
title_fullStr	A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
title_full_unstemmed	A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia
title_sort	pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2008
url	http://eprints.usm.my/51594/1/DR.%20CHIA%20BOON%20YANG%20-%2024%20pages.pdf
_version_	1747822084611899392

A pilot study compare the efficacy of amlodipine and captopril in the treatment for hypertensive urgency emergency department and primary care clinic Hospital Universiti Sains Malaysia

Similar Items