A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity

Aminoglycoside induced ototoxicity is one of the most common causes of acquired deafness, involving the auditory and vestibular system. The Vestibular and Audiotoxicity is frequently irreversible. In developing countries, eg Malaysia, aminoglycoside are more routinely used even for a minor infect...

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Main Author:	Eshamsol Kamar, Omar
Format:	Thesis
Language:	English
Published:	2008
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/51608/1/DR.%20ESHAMSOL%20KAMAR%20BIN%20OMAR%20-%2024%20pages.pdf
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spelling	my-usm-ep.516082022-02-28T03:07:18Z A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity 2008 Eshamsol Kamar, Omar R Medicine (General) Aminoglycoside induced ototoxicity is one of the most common causes of acquired deafness, involving the auditory and vestibular system. The Vestibular and Audiotoxicity is frequently irreversible. In developing countries, eg Malaysia, aminoglycoside are more routinely used even for a minor infection, since it is relatively cheap and easily available. However, studies conducted in Asian country had proved that aminoglycoside caused 10 to 20% of hearing loss. (mitochondrial A 15550 Mutation - An alteration or change, as in nature, form, or quality of a gene that maternally inherited gene during fetal life and has an association with hearing loss). People who carry the genetic mutation of mitochondrial DNA (mtDNA) A 15550, has a higher risk of having hearing loss when expose to aminoglycoside drug (eg: streptomycin, gentamycin etc) compare to them who do not carry the mutation gene. A study which was conducted in Japan, found that 40% of the patient who had hearing loss due to this drugs, also carry the mtDNA A1555G mutation. From this study, we hope that we can detect early genetic Al555G mutation, especially in newborn baby, so that prevention can be made early and precaution should be taken before prescribing amino glycoside drugs. Objectives: The purpose of this study is to determine the prevalence and association of mtDNA A1555G mutation in subjects with aminoglycoside-induced ototoxicity. Methodology: A cross sectional study was carried out in Otorhinolaryngology clinic HUSM and PKB, Kota Bharu from June 2007 to May 2008. Twenty two subjects with aminoglycoside induced ototoxicity and twenty two control subjects without ototoxicity after exposed to aminoglycosides were included in this study. Ototoxicity was confirmed by pure tone audiometry and distortion product otoacoustic emission (DPOAE). All eligible and consented patient was underwent buccal mucosa swab for further genetic analysis for mtDNA A 15550 mutation. Results: There was I subject (4.54%) in the aminoglycoside-induced ototoxicity group identified to have the mtDNA A 15550 mutation. There was no significant association between mtDNA Al555G mutation and ototoxicity in this study (P = 0.500). Conclusion: In our study, we found mtDNA Al555G mutation in one of our subject who had hearing loss secondary to ototoxic drug. Though, it was not significant statistically. There is a possibility that the prevalence of this mtDNA mutation is truly very low in our population. However, a further larger study with a bigger sample size and a wider area of coverage need to be done to confirm our finding. 2008 Thesis http://eprints.usm.my/51608/ http://eprints.usm.my/51608/1/DR.%20ESHAMSOL%20KAMAR%20BIN%20OMAR%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Eshamsol Kamar, Omar A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
description	Aminoglycoside induced ototoxicity is one of the most common causes of acquired deafness, involving the auditory and vestibular system. The Vestibular and Audiotoxicity is frequently irreversible. In developing countries, eg Malaysia, aminoglycoside are more routinely used even for a minor infection, since it is relatively cheap and easily available. However, studies conducted in Asian country had proved that aminoglycoside caused 10 to 20% of hearing loss. (mitochondrial A 15550 Mutation - An alteration or change, as in nature, form, or quality of a gene that maternally inherited gene during fetal life and has an association with hearing loss). People who carry the genetic mutation of mitochondrial DNA (mtDNA) A 15550, has a higher risk of having hearing loss when expose to aminoglycoside drug (eg: streptomycin, gentamycin etc) compare to them who do not carry the mutation gene. A study which was conducted in Japan, found that 40% of the patient who had hearing loss due to this drugs, also carry the mtDNA A1555G mutation. From this study, we hope that we can detect early genetic Al555G mutation, especially in newborn baby, so that prevention can be made early and precaution should be taken before prescribing amino glycoside drugs. Objectives: The purpose of this study is to determine the prevalence and association of mtDNA A1555G mutation in subjects with aminoglycoside-induced ototoxicity. Methodology: A cross sectional study was carried out in Otorhinolaryngology clinic HUSM and PKB, Kota Bharu from June 2007 to May 2008. Twenty two subjects with aminoglycoside induced ototoxicity and twenty two control subjects without ototoxicity after exposed to aminoglycosides were included in this study. Ototoxicity was confirmed by pure tone audiometry and distortion product otoacoustic emission (DPOAE). All eligible and consented patient was underwent buccal mucosa swab for further genetic analysis for mtDNA A 15550 mutation. Results: There was I subject (4.54%) in the aminoglycoside-induced ototoxicity group identified to have the mtDNA A 15550 mutation. There was no significant association between mtDNA Al555G mutation and ototoxicity in this study (P = 0.500). Conclusion: In our study, we found mtDNA Al555G mutation in one of our subject who had hearing loss secondary to ototoxic drug. Though, it was not significant statistically. There is a possibility that the prevalence of this mtDNA mutation is truly very low in our population. However, a further larger study with a bigger sample size and a wider area of coverage need to be done to confirm our finding.
format	Thesis
qualification_level	Master's degree
author	Eshamsol Kamar, Omar
author_facet	Eshamsol Kamar, Omar
author_sort	Eshamsol Kamar, Omar
title	A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
title_short	A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
title_full	A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
title_fullStr	A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
title_full_unstemmed	A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity
title_sort	study of mitochondrial a1555g mutation in aminogl ycoside induced ototoxicity
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2008
url	http://eprints.usm.my/51608/1/DR.%20ESHAMSOL%20KAMAR%20BIN%20OMAR%20-%2024%20pages.pdf
_version_	1747822087309885440

A study of mitochondrial A1555G mutation in aminogl ycoside induced ototoxicity

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