Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia

The study aims to determine the optimal allocation of long-acting insulin analogues (LAIA) among patients with Type 2 Diabetes Mellitus (T2DM) within a fixed budget. The objective was achieved via a three-phase study. In the first phase, the input values for economic evaluation analysis were obtaine...

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Main Author:	Ng, Chin Hui
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/51767/1/NG%20CHIN%20HUI%20-%20TESIS%20cut.pdf
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id	my-usm-ep.51767
record_format	uketd_dc
spelling	my-usm-ep.517672022-03-01T06:15:11Z Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia 2020-05 Ng, Chin Hui RS1-441 Pharmacy and materia medica The study aims to determine the optimal allocation of long-acting insulin analogues (LAIA) among patients with Type 2 Diabetes Mellitus (T2DM) within a fixed budget. The objective was achieved via a three-phase study. In the first phase, the input values for economic evaluation analysis were obtained from secondary data and cross-sectional study. The second phase involved cost-effectiveness analysis to determine the total quality-adjusted life years (QALYs) gained and costs for LAIA and NPH insulin among the targeted patients. UKPDS-OM Version 2.0 was used to estimate the impact of long-term diabetes-related complications, while simple cost-utility analysis was conducted to compare the impact of a severe hypoglycemic event between LAIA and NPH insulin usage. The outputs of these models were combined to obtain total QALY gained and the total cost over 40-year for LAIA versus NPH insulin. These values were then used as inputs for the budget optimization model in phase three. The result showed that T2DM patients treated with LAIA (especially insulin detemir) were projected to benefit from improved life year (LY) and QALYs compared to NPH insulin, especially when accounting for the impact of severe hypoglycemia. The findings from the budget optimization analysis showed that the best scenario for the additional budget was to allocate it to the high HbA1c level and elderly patients (above 60 years old), instead of the resources being equally allocated to all subgroups. 2020-05 Thesis http://eprints.usm.my/51767/ http://eprints.usm.my/51767/1/NG%20CHIN%20HUI%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Ng, Chin Hui Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
description	The study aims to determine the optimal allocation of long-acting insulin analogues (LAIA) among patients with Type 2 Diabetes Mellitus (T2DM) within a fixed budget. The objective was achieved via a three-phase study. In the first phase, the input values for economic evaluation analysis were obtained from secondary data and cross-sectional study. The second phase involved cost-effectiveness analysis to determine the total quality-adjusted life years (QALYs) gained and costs for LAIA and NPH insulin among the targeted patients. UKPDS-OM Version 2.0 was used to estimate the impact of long-term diabetes-related complications, while simple cost-utility analysis was conducted to compare the impact of a severe hypoglycemic event between LAIA and NPH insulin usage. The outputs of these models were combined to obtain total QALY gained and the total cost over 40-year for LAIA versus NPH insulin. These values were then used as inputs for the budget optimization model in phase three. The result showed that T2DM patients treated with LAIA (especially insulin detemir) were projected to benefit from improved life year (LY) and QALYs compared to NPH insulin, especially when accounting for the impact of severe hypoglycemia. The findings from the budget optimization analysis showed that the best scenario for the additional budget was to allocate it to the high HbA1c level and elderly patients (above 60 years old), instead of the resources being equally allocated to all subgroups.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ng, Chin Hui
author_facet	Ng, Chin Hui
author_sort	Ng, Chin Hui
title	Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
title_short	Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
title_full	Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
title_fullStr	Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
title_full_unstemmed	Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia
title_sort	efficiency and optimization modelling of healthcare resources for treating type 2 diabetes mellitus patient with basal insulin regimen in malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2020
url	http://eprints.usm.my/51767/1/NG%20CHIN%20HUI%20-%20TESIS%20cut.pdf
_version_	1747822098790744064

Efficiency And Optimization Modelling Of Healthcare Resources For Treating Type 2 Diabetes Mellitus Patient With Basal Insulin Regimen In Malaysia

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