Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form

Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form

Solid dispersion (SD) formulation has attracted much attention due to its potential in enhancing dissolution performance of poorly soluble active pharmaceutical ingredients (API). However, an overview of the dissolution performance of SDs implies inconsistent degree of dissolution improvement of...

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Main Author: Farhan, Ahmed Bassam
Format: Thesis
Language:English
Published: 2020
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/51822/1/AHMED%20BASSAM%20FARHAN%20-%20TESIS%20cut.pdf
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spelling my-usm-ep.518222022-03-07T09:05:38Z Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form 2020-05 Farhan, Ahmed Bassam RS1-441 Pharmacy and materia medica Solid dispersion (SD) formulation has attracted much attention due to its potential in enhancing dissolution performance of poorly soluble active pharmaceutical ingredients (API). However, an overview of the dissolution performance of SDs implies inconsistent degree of dissolution improvement of poorly soluble APIs in SD. Therefore, the main objective of this study is to determine the criteria of a good carrier system and drug candidate for enhanced dissolution performance of a solid dispersion system for a poorly soluble drug and dosage form consideration particularly the impact of compaction. To achieve these objectives, several SD systems were prepared in this study by spray drying and quenched 2020-05 Thesis http://eprints.usm.my/51822/ http://eprints.usm.my/51822/1/AHMED%20BASSAM%20FARHAN%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Farhan, Ahmed Bassam
Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
description Solid dispersion (SD) formulation has attracted much attention due to its potential in enhancing dissolution performance of poorly soluble active pharmaceutical ingredients (API). However, an overview of the dissolution performance of SDs implies inconsistent degree of dissolution improvement of poorly soluble APIs in SD. Therefore, the main objective of this study is to determine the criteria of a good carrier system and drug candidate for enhanced dissolution performance of a solid dispersion system for a poorly soluble drug and dosage form consideration particularly the impact of compaction. To achieve these objectives, several SD systems were prepared in this study by spray drying and quenched
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Farhan, Ahmed Bassam
author_facet Farhan, Ahmed Bassam
author_sort Farhan, Ahmed Bassam
title Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
title_short Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
title_full Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
title_fullStr Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
title_full_unstemmed Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form
title_sort investigation of dissolution performance and physical characterization on development of solid dispersion dosage form
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2020
url http://eprints.usm.my/51822/1/AHMED%20BASSAM%20FARHAN%20-%20TESIS%20cut.pdf
_version_ 1747822100981219328

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