Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application

Core@shell nanoparticles (Fe3O4@Au NPs) have multiple functions obtained in one stable entity and thus have been extensively investigated. Combining Fe3O4 and Au NPs in one core@shell nanostructure is a promising strategy for diagnostic biomedical applications. However, the conventional direct metho...

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Main Author:	Dheyab, Mohammed Ali
Format:	Thesis
Language:	English
Published:	2021
Subjects:	QC1 Physics (General)
Online Access:	http://eprints.usm.my/52055/1/MOHAMMED%20ALI%20DHEYAB.pdf
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id	my-usm-ep.52055
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spelling	my-usm-ep.520552022-03-28T07:07:55Z Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application 2021-02 Dheyab, Mohammed Ali QC1 Physics (General) Core@shell nanoparticles (Fe3O4@Au NPs) have multiple functions obtained in one stable entity and thus have been extensively investigated. Combining Fe3O4 and Au NPs in one core@shell nanostructure is a promising strategy for diagnostic biomedical applications. However, the conventional direct methods for Fe3O4@Au NPs synthesis are laborious and time-consuming. Therefore, this study presents a facile and rapid sonochemical technique of synthesising Fe3O4@Au NPs with excellent physicochemical properties for magnetic resonance imaging (MRI) and computed tomography (CT) scan. The Au shell is coated on Fe3O4 NPs using a Vibra-Cell ultrasonic solid horn with tip size, frequency and power output of ½ inch, 20 kHz and 750 watts, respectively within 10 minutes. The targeted zeta potential of - 46.125 mV was achieved under the optimum conditions of 10 ml of HAuCl4, 30 ml of sodium citrate (SC) and sonication amplitude of 40%, which is consistent (about 99.2%) with the actual average zeta potential (- 45.8 mV). The stability and monodispersing of Fe3O4NPs improved following modification to Fe3O4@Au, as indicated by the increase in zeta potential from - 24.2 mV to - 45.8 mV. The saturation magnetization (Ms) value of Fe3O4 was 54 emu/g, while that of Fe3O4@Au NP is 38 emu/g. In general, the sonochemical method effectively synthesis highly stable and monodisperse Fe3O4@Au NPs with an average size of about 20 nm within 10 minutes. 2021-02 Thesis http://eprints.usm.my/52055/ http://eprints.usm.my/52055/1/MOHAMMED%20ALI%20DHEYAB.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Fizik
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1 Physics (General)
spellingShingle	QC1 Physics (General) Dheyab, Mohammed Ali Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
description	Core@shell nanoparticles (Fe3O4@Au NPs) have multiple functions obtained in one stable entity and thus have been extensively investigated. Combining Fe3O4 and Au NPs in one core@shell nanostructure is a promising strategy for diagnostic biomedical applications. However, the conventional direct methods for Fe3O4@Au NPs synthesis are laborious and time-consuming. Therefore, this study presents a facile and rapid sonochemical technique of synthesising Fe3O4@Au NPs with excellent physicochemical properties for magnetic resonance imaging (MRI) and computed tomography (CT) scan. The Au shell is coated on Fe3O4 NPs using a Vibra-Cell ultrasonic solid horn with tip size, frequency and power output of ½ inch, 20 kHz and 750 watts, respectively within 10 minutes. The targeted zeta potential of - 46.125 mV was achieved under the optimum conditions of 10 ml of HAuCl4, 30 ml of sodium citrate (SC) and sonication amplitude of 40%, which is consistent (about 99.2%) with the actual average zeta potential (- 45.8 mV). The stability and monodispersing of Fe3O4NPs improved following modification to Fe3O4@Au, as indicated by the increase in zeta potential from - 24.2 mV to - 45.8 mV. The saturation magnetization (Ms) value of Fe3O4 was 54 emu/g, while that of Fe3O4@Au NP is 38 emu/g. In general, the sonochemical method effectively synthesis highly stable and monodisperse Fe3O4@Au NPs with an average size of about 20 nm within 10 minutes.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Dheyab, Mohammed Ali
author_facet	Dheyab, Mohammed Ali
author_sort	Dheyab, Mohammed Ali
title	Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
title_short	Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
title_full	Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
title_fullStr	Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
title_full_unstemmed	Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application
title_sort	iron oxide encapsulated gold colloidal nanoparticle via rapid sonochemical method for mri and ct imaging application
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Fizik
publishDate	2021
url	http://eprints.usm.my/52055/1/MOHAMMED%20ALI%20DHEYAB.pdf
_version_	1747822130023628800

Iron Oxide Encapsulated Gold Colloidal Nanoparticle Via Rapid Sonochemical Method For Mri And Ct Imaging Application

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