Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head

In this study, the aims are to determine the cumulative individual organ dose and tissue absorbed dose received from multiple CT exposures, to analyse cumulative effective dose (ED) and estimate the risk of radiation induced cancer due to multiple CT exposures. A total of 323 patients (183 males and...

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Main Author:	Roslee, Mohd Amirul Azrie Mohd
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/52061/1/MOHD%20AMIRUL%20AZRIE%20BIN%20MOHD%20ROSLEE.pdf
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spelling	my-usm-ep.520612022-03-28T08:20:11Z Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head 2021-04 Roslee, Mohd Amirul Azrie Mohd RK1-715 Dentistry In this study, the aims are to determine the cumulative individual organ dose and tissue absorbed dose received from multiple CT exposures, to analyse cumulative effective dose (ED) and estimate the risk of radiation induced cancer due to multiple CT exposures. A total of 323 patients (183 males and 140 females) underwent multiple CT head examinations (more than 3 exposures) at Advanced Medical and Dental Institute (AMDI) and Hospital Universiti Sains Malaysia (HUSM) were included in this study. Mostly patients were referred from Trauma and Neuro Departments of HUSM. Based on the study, lens organ dose consistently yields the highest values except for 13 times of multiple exposures; followed by thyroid’s dose (7.55 mSv) and lens (7.50 mSv). The highest organ dose was observed at lens (8.02 mSv). Based on International Commission on Radiological Protection (ICRP), the value was still below the level of radiation-induced cancer (100 mSv). However, mean absorbed dose for ≥ 3 times exposureexceeded the level of cataract formation stated by ICRP (0.5 Gy to 2 Gy for single exposure and 5 Gy for fractionated or protracted exposure). Both software calculation showed a positive correlation with number of exposures (r-value = 0.98). Besides, multiple CT exposures showed increment of the probability risk to induce cancer. Based on lifetime attributable risk (LAR) of incidence and mortality, the result showed that brain LAR was higher (53.87 and 50.17 per 100000 population) in female population compared to male population (21 and 17.45 per 100000 population) in 10 times multiple exposure. Increased exposures lead to significant increment of cancer risk with X2(7) = 76.89, p-value = 0.01(brain), X2(7) = 59.22, p-value = 0.01(salivary), with a mean value of 16.3 x 10-5 for LAR brain and 1.65 x 10-5 for salivary. The results also showed correlation of LAR incidence with mortality (r-value = 0.49 for brain and 0.42 for salivary). Thus, the repeated CT exposures should be minimized as to reduce the unnecessary radiation dose. The dose justification and optimisation of practice is crucial based on the concept of as low as reasonably practicable (ALARP). 2021-04 Thesis http://eprints.usm.my/52061/ http://eprints.usm.my/52061/1/MOHD%20AMIRUL%20AZRIE%20BIN%20MOHD%20ROSLEE.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RK1-715 Dentistry
spellingShingle	RK1-715 Dentistry Roslee, Mohd Amirul Azrie Mohd Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
description	In this study, the aims are to determine the cumulative individual organ dose and tissue absorbed dose received from multiple CT exposures, to analyse cumulative effective dose (ED) and estimate the risk of radiation induced cancer due to multiple CT exposures. A total of 323 patients (183 males and 140 females) underwent multiple CT head examinations (more than 3 exposures) at Advanced Medical and Dental Institute (AMDI) and Hospital Universiti Sains Malaysia (HUSM) were included in this study. Mostly patients were referred from Trauma and Neuro Departments of HUSM. Based on the study, lens organ dose consistently yields the highest values except for 13 times of multiple exposures; followed by thyroid’s dose (7.55 mSv) and lens (7.50 mSv). The highest organ dose was observed at lens (8.02 mSv). Based on International Commission on Radiological Protection (ICRP), the value was still below the level of radiation-induced cancer (100 mSv). However, mean absorbed dose for ≥ 3 times exposureexceeded the level of cataract formation stated by ICRP (0.5 Gy to 2 Gy for single exposure and 5 Gy for fractionated or protracted exposure). Both software calculation showed a positive correlation with number of exposures (r-value = 0.98). Besides, multiple CT exposures showed increment of the probability risk to induce cancer. Based on lifetime attributable risk (LAR) of incidence and mortality, the result showed that brain LAR was higher (53.87 and 50.17 per 100000 population) in female population compared to male population (21 and 17.45 per 100000 population) in 10 times multiple exposure. Increased exposures lead to significant increment of cancer risk with X2(7) = 76.89, p-value = 0.01(brain), X2(7) = 59.22, p-value = 0.01(salivary), with a mean value of 16.3 x 10-5 for LAR brain and 1.65 x 10-5 for salivary. The results also showed correlation of LAR incidence with mortality (r-value = 0.49 for brain and 0.42 for salivary). Thus, the repeated CT exposures should be minimized as to reduce the unnecessary radiation dose. The dose justification and optimisation of practice is crucial based on the concept of as low as reasonably practicable (ALARP).
format	Thesis
qualification_level	Master's degree
author	Roslee, Mohd Amirul Azrie Mohd
author_facet	Roslee, Mohd Amirul Azrie Mohd
author_sort	Roslee, Mohd Amirul Azrie Mohd
title	Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
title_short	Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
title_full	Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
title_fullStr	Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
title_full_unstemmed	Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head
title_sort	estimation of cumulative effective dose and potential risks of radiation exposure from multiple scans of ct head
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2021
url	http://eprints.usm.my/52061/1/MOHD%20AMIRUL%20AZRIE%20BIN%20MOHD%20ROSLEE.pdf
_version_	1747822131246268416

Estimation Of Cumulative Effective Dose And Potential Risks Of Radiation Exposure From Multiple Scans Of Ct Head

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