The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the pr...

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Main Author:	Ul Haq, Izaz
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf
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spelling	my-usm-ep.521222022-03-31T07:03:11Z The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia 2020-11 Ul Haq, Izaz R5-920 Medicine (General) Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the prevalence and clinical significance of NPM1, FLT3 and CEBPA mutations of AML in the Peninsula Malaysia. Three common and important gene mutations in AML FLT3 (exon 14-15, exon 20), NPM1 (exon 12), and CEBPA (exon 1) were determined by polymerase chain reaction and conformation-sensitive gel electrophoresis (CSGE) in 47 newly diagnosed adult patients with AML. Fisher-Exact Test was used to analyse the significant difference of AML with FLT3-ITD, NPM1, and CEBPA mutants in association with the clinical parameters. 2020-11 Thesis http://eprints.usm.my/52122/ http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Ul Haq, Izaz The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
description	Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the prevalence and clinical significance of NPM1, FLT3 and CEBPA mutations of AML in the Peninsula Malaysia. Three common and important gene mutations in AML FLT3 (exon 14-15, exon 20), NPM1 (exon 12), and CEBPA (exon 1) were determined by polymerase chain reaction and conformation-sensitive gel electrophoresis (CSGE) in 47 newly diagnosed adult patients with AML. Fisher-Exact Test was used to analyse the significant difference of AML with FLT3-ITD, NPM1, and CEBPA mutants in association with the clinical parameters.
format	Thesis
qualification_level	Master's degree
author	Ul Haq, Izaz
author_facet	Ul Haq, Izaz
author_sort	Ul Haq, Izaz
title	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
title_short	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
title_full	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
title_fullStr	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
title_full_unstemmed	The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
title_sort	clinical significance of npm1, flt3 and cebpa gene mutations in adult patients with acute myeloid leukaemia
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2020
url	http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf
_version_	1747822135610441728

The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia

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